Remote control of macrophage production by cancer

Abstract

The communication between tumor and host cells involves signals that act across extended distances in the body. Recent evidence indicates that the hormone angiotensin II is overproduced by lung adenocarcinoma to remotely expand bone marrow-derived hematopoietic stem cells. This process amplifies the supply of tumor-associated macrophages, which promote disease progression.

Keywords: :

• Angiotensin II
• NSCLC
• cancer
• hematopoietic stem cell
• lung adenocarcinoma
• macrophage
• monocyte

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.