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OncoImmunology Volume 2, 2013 - Issue 5
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High endothelial venules

Help or hindrance in the quest for antitumor immunity?

Awen Gallimore Institute of Infection and Immunity; School of Medicine; Cardiff University; Cardiff, UKCorrespondence[email protected]
,
Andrew Godkin Institute of Infection and Immunity; School of Medicine; Cardiff University; Cardiff, UK
&
Ann Ager Institute of Infection and Immunity; School of Medicine; Cardiff University; Cardiff, UK
Article: e24272 | Received 08 Mar 2013, Accepted 12 Mar 2013, Published online: 01 May 2013
 
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Abstract

Recently, a number of studies have documented the presence of high endothelial venules in both mouse and human tumors. The significance of these highly specialized blood vessels within neoplastic lesions, and notably their capacity to influence anticancer immune responses and tumor progression, remains to be fully understood.

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