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OncoImmunology Volume 3, 2014 - Issue 2
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Location, location, location

CD103 demarcates intraepithelial, prognostically favorable CD8+ tumor-infiltrating lymphocytes in ovarian cancer

John R Webb Trev and Joyce Deeley Research Centre; British Columbia Cancer Agency; Victoria, BC Canada; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC CanadaCorrespondence[email protected]
,
Katy Milne Trev and Joyce Deeley Research Centre; British Columbia Cancer Agency; Victoria, BC Canada
&
Brad H Nelson Trev and Joyce Deeley Research Centre; British Columbia Cancer Agency; Victoria, BC Canada; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada; Department of Medical Genetics; University of British Columbia; Vancouver, BC Canada
Article: e27668 | Received 23 Dec 2013, Accepted 27 Dec 2013, Published online: 10 Jan 2014
 
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Abstract

Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correlating with increased disease-specific survival.

Citation: Webb JR, Milne K, Nelson BH. Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8+ tumor-infiltrating lymphocytes in ovarian cancer. OncoImmunology 2013; 2:e27668; 10.4161/onci.27668

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