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Abstract
Post-translational modifications of core histones are important for various DNA-templated processes such as transcription and repair. We recently reported that the ALFIN LIKE 6 (AL6) gene, identified in a forward genetic screen, is critical for phosphate deficiency-induced root hair formation and several other processes associated with the regulation of cellular phosphate homeostasis. AL6 contains a Plant Homeo Domain (PHD) finger that can bind to trimethylated lysine 4 of histone H3 (H3K4me3). Homozygous mutants defective in AL6 expression form very short root hairs under phosphate-deficient conditions, presumably caused by altered expression of putative primary and secondary down-stream targets of AL6. In this Addendum, we speculate about possible roles of AL6, H3K4 trimethylation and other chromatin modifications in the adaptation of plants to low phosphate availability.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Acknowledgments
This work was supported by grants from Academia Sinica. We thank the Arabidopsis Biological Resource Center (Ohio State University) for providing the T-DNA insertion mutants and wild-type seeds used in this study. We also thank Marjori Matzke (IPMB, Taiwan) for valuable suggestions and critical comments on the manuscript, Yuki Nakamura (IPMB, Taiwan) for providing npc4-1 and npc4-2 mutant seeds and Christoph Benning (Michigan State University) for providing sqd2 mutant seeds.
