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Abstract
Transcription of ncDNA occurs throughout eukaryotic genomes, generating a wide array of ncRNAs. One large class of ncRNAs include those transcribed over the promoter regions of nearby protein coding genes. Recent studies primarily focusing on individual genes have uncovered multiple mechanisms by which promoter-associated transcriptional activity locally alters gene expression.
Acknowledgments
We thank Robin Monteverde, Justin Pruneski, Beth Raupach and Travis Mavrich for their critical reading of this manuscript. J.A.M. is supported by NIH grant GM080470.