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Abstract
Whereas in yeast the function and mode of action of nuclear RNAi are well documented, mammalian nuclear RNAi is a matter of debates. Several papers support a role for nuclear Argonaute in alternative splicing. However, the molecular mechanism remains elusive. Here, we discuss the human nuclear RNAi mechanism in light of what is known of the yeast process.
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Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Acknowledgments
The work discussed here was supported by the European Commission Sixth Framework Programme (Integrated Project SIROCCO contract number LSHG-CT-2006–037900, to AHB) and by the Agence Nationale de la Recherche (to CM and AHB).