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Abstract
The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Acknowledgments
We would like to thank Emmalene Bartlett, Ke Zhang and Martin Kos for proofreading the manuscript. B.P.H. and T.F. were supported by a grant from the Ministry of Science, Research and the Arts of Baden-Wuerttemberg.