Preparation and characterization of a new inorganic cation-exchanger: Zirconium (IV) iodosilicate: Analytical applications for metal content determination in pharmaceutical sample and synthetic mixture

Abstract

A new inorganic cation exchanger zirconium(IV) iodosilicate was synthesized and characterized on the basis of X-ray, TGA-DTA, FTIR and SEM studies. This cation-exchanger was found to have a good ion-exchange capacity (0.85 meq g⁻¹ for Na⁺), high thermal and chemical stability. The chemical composition reveals that Zr:I:Si is in the molar ratio 1:1.57: 1. The chemical stability data shows that material is quite stable in common mineral acids, bases and organic solvents of analytical interest upto 2.0 M. Thermal analysis shows that exchanger retain 80% of ion-exchange capacity upto 400°C. Effect of time and temperature on the sorption of metal ions on this material was explored. The sorption behavior of metal ions was studied in acetic acid, formic acid, DMSO, DMF and succinic acid. Some important and analytically diffi cult quantitative binary separations viz. Cd(II)-Ba(II), Cd(II)-Ni(II), Cd(II)-Cu(II), Cd(II)-Fe(III) etc. were achieved. The practical applicability of the cation-exchanger was demonstrated in the separation of Zn(II)-Fe(III) from a synthetic mixture as well as from real sample of pharmaceutical formulation.

Keywords:

• Synthesis
• Inorganic ion-exchanger
• Zirconium(IV) iodosilicate
• Characterization
• Analytical application
• Pharmaceutical formulation