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ABSTRACT
In this study, we report glycolipid changes in the nuclear subcellular fraction from hypoxic rat brains. Male Wistar rats at the age of three months were subjected to sodium nitrite-induced hypoxia. Te nuclear fraction was isolated and lipids were extracted. The glycolipid content was measured by spectrophotometry and thin-layer chromatography.
In controls, gangliosides and cerebrosides were the major glycolipid classes. In the nuclear membrane of hypoxic brains, we found increased levels of total glycolipids (5.2-fold), gangliosides (4.1-fold), and cerebrosides (5.9-fold). These changes reflect the disturbances in the glycolipid turnover. Most probably they are associated with impaired energy metabolism. The accumulation of glycolipids may be interpreted as a physiological adaptive response to hypoxia.