![Sample our Food Science & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5936/TOC-Subject-Sample-2021-Food-Science-Technology.jpg"})
ABSTRACT
Cobalt (Co) and its compounds are shown to improve hematological parameters. Long-term treatment with Co(II) increased hemoglobin content in a dose- and time-dependent manner in mature mice (day 45 to day 90) while it was reduced in immature mice (day 18 to day 30). Higher Hb was measured in samples treated with CoCl2 compared to those treated with Co-EDTA. Plasma Fe concentration was significantly higher in samples treated with Co-EDTA compared to those exposed to CoCl2. Lower concentrations were measured only in mature animals. Co(II) concentration increased but not in a dose-dependent manner. In general more Co(II) was measured in samples treated with CoCl2 possibly due to the stability of the complex Co-EDTA. Surprisingly, mature mice had less Co(II) in their plasma compared to day 18 mice. Strong correlation between plasma Co(II) and iron concentration was found in samples of mice treated with Co-EDTA. Co(II) concentration showed inverse correlation with hemoglobin in mice treated with low dose Co-EDTA. Such relationship was found for day 45 and day 60 mice exposed to high dose CoCl2. Immature mice are more sensitive to Co(II) treatment and show signs of anemia. It has a significant impact on hemoglobin biosynthesis possibly due to its effect on iron metabolism.
