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ABSTRACT
A pilot study was carried out to investigate the association of five single nucleotide polymorphisms of the IL-10 gene (-3575T/A, -2849G/A, -2763C/A, -1082G/A, -592C/A) with the risk of lupus-nephritis in Bulgarian female patients. We found a strong association between the -592 AA and CA genotypes (P = 0.009, OR 4.38, 95%CI 1.4–13.6) and the A allele (P = 0.037, OR 2.25, 95%CI 1–5) with the disease. Although statistically insignificant, the frequency of the IL-10 -3575TT, -2763CC, -2849GG and -1082GG genotypes was higher in the patients compared to the controls, which resulted in an increased odds ratio (OR). The haplotype analysis revealed an association between the IL-10 -3575T/-2849G/-2763C/-592A haplotype and lupus-nephritis (P = 0.04).