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ABSTRACT
Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing nearly one third of all pediatric cancers. About 30 % of the children with ALL have a gene marker. The most frequent abnormality is t (12; 21) resulting in TEL-AML1 gene rearrangement. This molecular marker can be detected in 20 % to 30 % of the cases with ALL. In this paper the survival analysis is used to determine the prognostic significance of TEL-AML1 and to model the time it takes for relapse or death. The data follow 8-year disease progression of 160 patients from the Specialized Children's Oncohematology Hospital in Sofia, Bulgaria. The gene marker TEL-AML1 was detected in 33 of the patients. For estimating event (relapse or death) free survival rate, the Kaplan-Meier method is used. Time to event is calculated as the time from study entry to first event or data of last contact. The log-rank test is used for comparison of survival curves between the two groups—with and without TEL-AML1. Multivariate analysis is conducted by using Cox proportional hazards regression.