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ABSTRACT
Bronchial Hyperresponsiveness (BHR) is a risk factor for asthma but it can be observed in allergic rhinitis (AR) and healthy subjects, too. The mechanisms of genetic susceptibility to BHR are unknown. In general, it is thought to result from both genetic and environmental factors. Some studies have demonstrated that nonspecific airway hyperresponsiveness is associated with a specific β2-adrenergic receptor (β2-AR) genotype in asymptomatic healthy subjects. The present study was performed to determine the impact of single nucleotide polymorphism (SNP) on allergic rhinitis patients with evidence for bronchial hyperresponsiveness. One hundred allergic rhinitis patients analyzed for BHR and forty healthy controls were genotyped for polymorphism of the β2-AR gene. Nonspecific airway hyperesponsiveness was measured using the methacholine bronchoprovocation (BPT) test. Polymerase chain reaction (PCR) was used to identify (Arg16/Gly) polymorphism at codon 16 in the β2-AR gene. It was observed that allergic rhinitis patients who are homozygous for the Gly16 allele are more responsive to methacholine than patients who carry the Arg16 allele.