Identification of mtDNA 7028C and 16519T Polymorphisms in a Pediatric-Onset Cyclic Vomiting Syndrome (CVS) Patient

ABSTRACT

Cyclic vomiting syndrome (CVS) is a functional disorder that may occur in any age group of patients. In the past the disorder was considered to be fairly uncommon, of unknown etiology. Most cases of CVS have been described as sporadic, but family history may be an important factor. Here we present an 18-year-old male patient with symptoms of recurrent spells of intense vomiting. The objective of this study was to determine the presence of mtDNA polymorphisms in a patient with a pediatric-onset CVS as an indication of genetic association that confers an increased risk towards disease pathogenesis.

Keywords:

• 16519T
• 3010A
• cyclic vomiting syndrome
• mitochondrial DNA