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Full Length Article

Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation

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Pages 247-260 | Received 27 Jul 2015, Accepted 08 Sep 2015, Published online: 13 Mar 2019

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Yan Wang, Hui Sun, Jianwu Zhang, Zhiyang Xia & Wei Chen. (2020) Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways. Bioscience, Biotechnology, and Biochemistry 84:12, pages 2533-2544.
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Fabio Mastrogiovanni, Roberta Bernini, Loredana Basiricò, Umberto Bernabucci, Margherita Campo, Annalisa Romani, Luca Santi & Nicola Lacetera. (2020) Antioxidant and anti-inflammatory effects of pomegranate peel extracts on bovine mammary epithelial cells BME-UV1. Natural Product Research 34:10, pages 1465-1469.
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Articles from other publishers (21)

Shahid Karim, Mohammad Imran Khan & Aftab Ahmad. (2023) A mechanistic insight into cytokines and growth factors in saudi pomegranate peel extract (Punica granatum L.) mediated diabetic wound healing in alloxan induced diabetic rats. Journal of King Saud University - Science 35:10, pages 102952.
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Nahid Tajvar Nasab, Mohammad Jalili‐Nik, Amir R. Afshari, Azam Rezaei Farimani & Mohammad Soukhtanloo. (2023) Urolithin B inhibits proliferation and migration and promotes apoptosis and necrosis by inducing G2/M arrest and targeting MMP‐2/‐9 expression in osteosarcoma cells. Journal of Biochemical and Molecular Toxicology 37:12.
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Muthana M. Jghef, Khadija Boukholda, Yassine Chtourou, Bernd L. Fiebich, Mohammed Kebieche, Rachid Soulimani, Fatiha Chigr & Hamadi Fetoui. (2023) Punicalagin attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats: Biochemical, immunohistochemical, and in silico molecular docking studies. Chemico-Biological Interactions 385, pages 110745.
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Mariam Ali Abo-Saif, Amany E. Ragab, Amera O. Ibrahim, Othman F. Abdelzaher, Ahmed B. M. Mehanyd, Maha Saber-Ayad & Ola A. El-Feky. (2023) Pomegranate peel extract protects against the development of diabetic cardiomyopathy in rats by inhibiting pyroptosis and downregulating LncRNA-MALAT1. Frontiers in Pharmacology 14.
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Azar Hosseini, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2023) Protective effects of pomegranate (Punica granatum) and its main components against natural and chemical toxic agents: A comprehensive review. Phytomedicine 109, pages 154581.
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Mostafa D. Mostafa, Magda A ElKomy, Azza I. Othman, Maggie E. Amer & Mohamed A. El-Missiry. (2022) Epigallocatechin-3-gallate Enhances Cognitive and Memory Performance and Protects Against Brain Injury in Methionine-induced Hyperhomocysteinemia Through Interdependent Molecular Pathways. Neurotoxicity Research 40:6, pages 2103-2116.
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Haitham L. Abdulhadi, Banan R. Dabdoub, Loay H. Ali, Azza I. Othman, Maggie E. Amer & Mohamed A. El-Missiry. (2022) Punicalagin protects against the development of pancreatic injury and insulitis in rats with induced T1DM by reducing inflammation and oxidative stress. Molecular and Cellular Biochemistry 477:12, pages 2817-2828.
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Alayn’ Al-marddyah A. Al-khawalde, Mohammad H. Abukhalil, Muthana M. Jghef, Manal A. Alfwuaires, Fatima S. Alaryani, Saleem H. Aladaileh, Abdulmohsen I. Algefare, Shaik Karimulla, Fawaz Alasmari, Hammad Khalifeh Aldal’in, Abdulkareem A. Alanezi & Osama Y. Althunibat. (2022) Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death. International Journal of Molecular Sciences 23:20, pages 12334.
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Peng Chen, Zhiei Guo, Fuchao Chen, Yue Wu & Benhong Zhou. (2022) Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived From Ellagitannins. Frontiers in Pharmacology 13.
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Fang Chen, Huan-Yu Zhang, Di He, Chun-Mei Rao & Bo Xu. (2022) Cardioprotective Effect of <i>Gynostemma pentaphyllum</i> against Streptozotocin Induced Cardiac Toxicity in Rats via Alteration of AMPK/Nrf2/HO-1 Pathway. Journal of Oleo Science 71:7, pages 991-1002.
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Alexander V. Sirotkin & Adriana Kolesarova. 2022. Environmental Contaminants and Medicinal Plants Action on Female Reproduction. Environmental Contaminants and Medicinal Plants Action on Female Reproduction 245 399 .
Myeda Saeed, Ali Sharif, Saeed Ul Hassan, Bushra Akhtar, Faqir Muhammad & Maryam Malik. (2021) Cyperus iria aqueous-ethanol extract ameliorated hyperglycemia, oxidative stress, and regulated inflammatory cytokines in streptozotocin-induced diabetic rats. Environmental Science and Pollution Research 29:3, pages 4769-4784.
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Ana F. Raimundo, Sofia Ferreira, Francisco A. Tomás-Barberán, Claudia N. Santos & Regina Menezes. (2021) Urolithins: Diet-Derived Bioavailable Metabolites to Tackle Diabetes. Nutrients 13:12, pages 4285.
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Renan Aparecido Fernandes Scappaticci, Andresa Aparecida Berretta, Elina Cassia Torres, Andrei Felipe Moreira Buszinski, Gabriela Lopes Fernandes, Thaila Fernanda dos Reis, Francisco Nunes de Souza-Neto, Luiz Fernando Gorup, Emerson Rodrigues de Camargo & Debora Barros Barbosa. (2021) Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats. Antibiotics 10:11, pages 1343.
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Hadi Bazyar, Seyed Ahmad Hosseini, Sirous Saradar, Delsa Mombaini, Mohammad Allivand, Maryam Labibzadeh & Meysam Alipour. (2021) Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial . Journal of Complementary and Integrative Medicine 18:2, pages 405-411.
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Jie Xu, Ke Cao, Lin Zhao, Zhihui Feng, Zhizhong Dong, Jianke Li & Jiankang Liu. (2021) The effects and mechanisms of pomegranate in the prevention and treatment of metabolic syndrome. Traditional Medicine and Modern Medicine 03:04, pages 223-237.
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Thanusha Ganesan, Ajantha Sinniah, Zamri Chik & Mohammed Abdullah Alshawsh. (2020) Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer. Nutrients 12:8, pages 2430.
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Mohamed Fizur Nagoor Meeran, Farah Laham, Sheikh Azimullah, Saeed Tariq & Shreesh Ojha. (2018) α-Bisabolol abrogates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and intrinsic pathway of apoptosis in rats. Molecular and Cellular Biochemistry 453:1-2, pages 89-102.
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Sithuraj Saranya, Rathinasamy Baskaran, Paramasivan Poornima & Viswanadha Vijaya Padma. (2018) Berbamine ameliorates isoproterenol‐induced myocardial infarction by inhibiting mitochondrial dysfunction and apoptosis in rats. Journal of Cellular Biochemistry 120:3, pages 3101-3113.
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Mohammed A. El-Missiry, Magda A. ElKomy, Azza I. Othman & Ali M. AbouEl-ezz. (2018) Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain. Biomedicine & Pharmacotherapy 102, pages 472-480.
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Azza I. Othman, Magda M. Elkomy, M.A. El-Missiry & Mohammed Dardor. (2017) Epigallocatechin-3-gallate prevents cardiac apoptosis by modulating the intrinsic apoptotic pathway in isoproterenol-induced myocardial infarction. European Journal of Pharmacology 794, pages 27-36.
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