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Original Articles

The role of thymoquinone as a potent antioxidant in ameliorating the neurotoxic effect of sodium arsenate in female rat

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Pages 160-167 | Received 22 May 2017, Accepted 03 Jul 2017, Published online: 08 Mar 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Ümit Erdoğan, Özlem Özmen & Merve Özer. (2023) Wound Healing, Anti-analgesic, and Antioxidant Activity of Nigella sativa Linn., Essential Based Topical Formulations in Rat Model Experimental Skin Defects. Journal of Essential Oil Bearing Plants 26:1, pages 45-60.
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Mukaddes Pala, Ismail Meral, Nilgun Pala Acikgoz, Şenay Gorucu Yilmaz, Elif Taslidere, Sema Karaca Okur, Seyma Acar & Fahri Akbas. (2022) Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus. Neurological Research 44:8, pages 726-737.
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Osama A Badary, Marwa S Hamza & Rajiv Tikamdas. (2021) Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure. Drug Design, Development and Therapy 15, pages 1819-1833.
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Nashwa Amin, Xiaoxue Du, Shijia Chen, Qiannan Ren, Azhar B. Hussien, Benson O.A. Botchway, Zhiying Hu & Marong Fang. (2021) Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway. Expert Opinion on Therapeutic Targets 25:7, pages 597-612.
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Mustafa Ogden, Sahika Burcu Karaca, Gulcin Aydin, Ulas Yuksel, Ahmet Turan Dagli, Suleyman Akkaya & Bulent Bakar. (2021) The Healing Effects of Thymoquinone and Dexpanthenol in Sciatic Nerve Compression Injury in Rats. Journal of Investigative Surgery 34:5, pages 504-512.
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Hamid A Saleh, Gamal S. Abd El-Aziz, Hesham N. Mustafa, Magdy El-Fark, Ahmed Mal, Majdah Aburas & Abdel Halim Deifalla. (2019) Thymoquinone ameliorates oxidative damage and histopathological changes of developing brain neurotoxicity. Journal of Histotechnology 42:3, pages 116-127.
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Articles from other publishers (41)

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Mohamad Hesam Shahrajabian & Wenli Sun. (2024) Importance of Thymoquinone, Sulforaphane, Phloretin, and Epigallocatechin and their Health Benefits. Letters in Drug Design & Discovery 21:2, pages 209-225.
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Farzad Ghasemi, Amir Nili‐Ahmadabadi, Navid Omidifar & Maryam Nili‐Ahmadabadi. (2023) Protective potential of thymoquinone against cadmium, arsenic, and lead toxicity: A short review with emphasis on oxidative pathways. Journal of Applied Toxicology 43:12, pages 1764-1777.
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Fariba Sharififar, Mokarame Pudineh Morref & Somayyeh Karami-Mohajeri. (2023) Antioxidant Effects of Methanolic Extract of Quercus infectoria as a Supplement against Oxidative Stress Induced by Sub-acute Exposure to Arsenic; An in vivo Study . The Natural Products Journal 13:7.
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Nurhanisah Othman, Siti Nurul Ain Md. Jamil, Mas Jaffri Masarudin, Ruqayyah Ainul Bashirah Mohd Jusoh & Mohammed Numan Alamassi. (2023) Increased radical scavenging activity of thymoquinone and l -ascorbic acid dual encapsulated in palmitoyl-chitosan nanoparticles in a human normal lung fibroblast, MRC-5 due to synergistic antioxidative effects . RSC Advances 13:40, pages 27965-27983.
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Ümit ERDOĞAN. (2022) Investigation of Antioxidant Activity of Thymoquinone and Its Protective Effect on Edible Oils. Bilge International Journal of Science and Technology Research 6:2, pages 112-117.
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Heba M. Fahmy, Mostafa M. Ahmed, Ayman S. Mohamed, Engy Shams-Eldin, Taiseer M. Abd El-Daim, Amena S. El-Feky, Amira B. Mustafa, Mai W. Abd Alrahman, Faten F. Mohammed & Mohamed M. Fathy. (2022) Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats. BMC Pharmacology and Toxicology 23:1.
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Karmand Salih Hamaamin & Bushra Hassan Marouf. (2022) Chemopreventive Efficacy of Thymoquinone in Chemically Induced Urinary Bladder Carcinogenesis in Rat. BioMed Research International 2022, pages 1-12.
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Mohammed Shariq Iqbal, Anjuman Gul Memon, Ausaf Ahmad, Garima Gupta & Zahra Iqbal. (2022) RP-HPLC estimation of thermal oxidation of thymoquinone in Nigella sativa with reference to its antioxidant potential and vis-a-vis in-vitro DNA damage inhibition. Plant Physiology Reports 27:3, pages 498-507.
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Manzar Alam, Gulam Mustafa Hasan, Md Meraj Ansari, Rishi Sharma, Dharmendra Kumar Yadav & Md Imtaiyaz Hassan. (2022) Therapeutic implications and clinical manifestations of thymoquinone. Phytochemistry 200, pages 113213.
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Mandana Lotfi, Sohrab Kazemi, Anahita Ebrahimpour, Fereshteh Pourabdolhossein, Leila Satarian, Atiyeh Eghbali & Ali Akbar Moghadamnia. (2022) Thymoquinone Improved Nonylphenol-Induced Memory Deficit and Neurotoxicity Through Its Antioxidant and Neuroprotective Effects. Molecular Neurobiology 59:6, pages 3600-3616.
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Nur Musfirah Mahmud, Luminita Paraoan, Nurliza Khaliddin & Tengku Ain Kamalden. (2022) Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways. Frontiers in Cellular Neuroscience 16.
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Shakila Sabir, Uzma Saleem, Muhammad Sajid Hamid Akash, Muhammad Qasim & Zunera Chauhdary. (2022) Thymoquinone Induces Nrf2 Mediated Adaptive Homeostasis: Implication for Mercuric Chloride-Induced Nephrotoxicity. ACS Omega 7:8, pages 7370-7379.
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Dilek Kuzay, Ergin Dileköz & Çiğdem Özer. (2022) Effects of thymoquinone in a rat model of reserpine-induced depression. Brazilian Journal of Pharmaceutical Sciences 58.
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Getinet M. Adinew, Equar Taka, Bereket Mochona, Ramesh B. Badisa, Elizabeth A. Mazzio, Rashid Elhag & Karam F. A. Soliman. (2021) Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment. Nutrients 14:1, pages 79.
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Noreen Samad, Natasha Manzoor, Zahra Muneer, Sheraz A. Bhatti & Imran Imran. (2021) Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice. Metabolic Brain Disease 36:8, pages 2535-2552.
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Prathiba Gnanasekaran, Anitha Roy, Nagabhishek Sirpu Natesh, Varshini Raman, Priyanka Ganapathy & Madan Kumar Arumugam. (2021) Removal of microbial pathogens and anticancer activity of synthesized nano-thymoquinone from Nigella sativa seeds. Environmental Technology & Innovation 24, pages 102068.
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Shoukath M. Ali, Paul Chen, Saifuddin Sheikh, Ateeq Ahmad, Moghis Ahmad, Mahesh Paithankar, Brijesh Desai, Piyush Patel, Mujtaba Khan, Alok Chaturvedi, Ronak Patel, Dharmendra T. Panchal, Kuntal Shah, Vipul Chavda, Banshi D. Saboo, Alpesh Patel & Imran Ahmad. (2021) Thymoquinone with Metformin Decreases Fasting, Post Prandial Glucose, and HbA1c in Type 2 Diabetic Patients. Drug Research 71:06, pages 302-306.
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Mohamed Mekhemar, Yasmine Hassan & Christof Dörfer. (2020) Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy. Antioxidants 9:12, pages 1260.
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N. K. Isaev, N. S. Chetverikov, E. V. Stelmashook, E. E. Genrikhs, L. G. Khaspekov & S. N. Illarioshkin. (2020) Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology. Biochemistry (Moscow) 85:2, pages 167-176.
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Hanan A. Bashmail, Aliaa A. Alamoudi, Abdulwahab Noorwali, Gehan A. Hegazy, Ghada M. Ajabnoor & Ahmed M. Al-Abd. (2020) Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism. Molecules 25:2, pages 426.
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Mohammed Bule, Shekoufeh Nikfar, Mohsen Amini & Mohammad Abdollahi. (2020) The antidiabetic effect of thymoquinone: A systematic review and meta-analysis of animal studies. Food Research International 127, pages 108736.
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Mohammed Shariq Iqbal, Asif Jafri, Md Arshad & Mohammad Israil Ansari. (2019) Stress response due to sodium azide treatment inside Nigella sativa L. plant and its effect on antioxidative property. Biocatalysis and Agricultural Biotechnology 19, pages 101171.
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AY Al-Brakati, RB Kassab, MS Lokman, EK Elmahallawy, HK Amin & AE Abdel Moneim. (2018) Role of thymoquinone and ebselen in the prevention of sodium arsenite–induced nephrotoxicity in female rats. Human & Experimental Toxicology 38:4, pages 482-493.
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Zahra Karimi, Adel Mirza Alizadeh, Jafar Ezzati Nazhad Dolatabadi & Parvin Dehghan. (2019) Nigella sativa and its Derivatives as Food Toxicity Protectant Agents. Advanced Pharmaceutical Bulletin 9:1, pages 22-37.
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Rami B. Kassab, Maha S. Lokman & Ehab A. Essawy. (2018) Neurochemical alterations following the exposure to di-n-butyl phthalate in rats. Metabolic Brain Disease 34:1, pages 235-244.
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Nurhanisah Othman, Mas Masarudin, Cha Kuen, Nurul Dasuan, Luqman Abdullah & Siti Md. Jamil. (2018) Synthesis and Optimization of Chitosan Nanoparticles Loaded with L-Ascorbic Acid and Thymoquinone. Nanomaterials 8:11, pages 920.
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Mustafa S. Atta, Ali H. El-Far, Foad A. Farrag, Mohamed M. Abdel-Daim, Soad K. Al Jaouni & Shaker A. Mousa. (2018) Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats. Oxidative Medicine and Cellular Longevity 2018, pages 1-10.
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Fakiha Firdaus, Mohd Faraz Zafeer, Masood Ahmad & Mohammad Afzal. (2018) Anxiolytic and anti-inflammatory role of thymoquinone in arsenic-induced hippocampal toxicity in Wistar rats. Heliyon 4:6, pages e00650.
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Mehdi Goudarzi, Shivasadat Amiri, Ali Nesari, Azam Hosseinzadeh, Esrafil Mansouri & Saeed Mehrzadi. (2018) The possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats. Life Sciences 198, pages 38-45.
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