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Egyptian Journal of Basic and Applied Sciences Volume 5, 2018 - Issue 1
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Original Articles

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of benzimidazole derivatives

Snehlata YadavFaculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak124001, India
,
Balasubramanian NarasimhanFaculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak124001, IndiaCorrespondence[email protected]
,
Siong Meng LimFaculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia;Collaborative Drug Discovery Research (CDDR) Group, Pharmaceutical Life Sciences Community of Research, Universiti Teknologi MARA (UiTM), 40450Shah Alam, Selangor Darul Ehsan, Malaysia
,
Kalavathy RamasamyFaculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia;Collaborative Drug Discovery Research (CDDR) Group, Pharmaceutical Life Sciences Community of Research, Universiti Teknologi MARA (UiTM), 40450Shah Alam, Selangor Darul Ehsan, Malaysia
,
Mani VasudevanDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah51452, Saudi Arabia
,
Syed Adnan Ali ShahFaculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia;Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus, 42300Bandar Puncak Alam, Selangor D.E., Malaysia
&
Abhishek MathurCollaborative Research Group, National Centre of Fungal Taxonomy (in Association with Environmental Biotech & Engineering Co.), New Delhi110012, India
 show all
Pages 100-109 | Received 08 Jul 2017, Accepted 05 Nov 2017, Published online: 06 Mar 2019

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Raju Chedupaka, Venkatesham Papisetti, Akanksha Ashok Sangolkar & Rajeswar Rao Vedula. (2022) A Facile One-Pot Synthesis of Benzimidazole-Linked Pyrrole Structural Motifs via Multicomponent Approach: Design, Synthesis, and Molecular Docking Studies. Polycyclic Aromatic Compounds 42:10, pages 7034-7048.
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Gurpreet Kaur, Radha Moudgil, Mussarat Shamim, Vivek Kumar Gupta & Bubun Banerjee. (2021) Camphor sulfonic acid catalyzed a simple, facile, and general method for the synthesis of 2-arylbenzothiazoles, 2-arylbenzimidazoles, and 3H-spiro[benzo[d]thiazole-2,3′-indolin]-2′-ones at room temperature. Synthetic Communications 51:7, pages 1100-1120.
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Vishwajeet Amar Singh Pardeshi, Narendra Singh Chundawat, Sultan Ismail Pathan, Priyal Sukhwal, Tejpal Pal Singh Chundawat & Girdhar Pal Singh. (2021) A review on synthetic approaches of benzimidazoles. Synthetic Communications 51:4, pages 485-513.
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Articles from other publishers (23)

Rashmi Shah, Prabhakar Kumar Verma, Manisha Shah & Vipan Kumar. (2022) Synthesis and antimycobacterial evaluation of pyrazinamide, benzimidazole and carboxamide derivatives. Journal of Heterocyclic Chemistry 60:2, pages 183-200.
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Dhanraj Kamble, Anil Shankarwar, Yuvraj Sarnikar, Radhakrushna Tigote, Mubarak Shaikh & Pravin Chavan. (2022) One-pot Synthesis of Substituted Benzimidazole Derivatives under Ultrasonic Irradiation Using ZnFe2O4 Reusable Catalyst. Chemistry Journal of Moldova 17:2, pages 94-100.
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José Maurício dos Santos Filho & Marcos Venícius Batista de Souza Castro. (2022) Synthesis, structural characterization, and antimicrobial activity of novel ferrocene-N-acyl hydrazones designed by means of molecular simplification strategy Celebrating the 100th anniversary of the birth of Professor Paulo Freire. Journal of Organometallic Chemistry 979, pages 122488.
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Himani Chaurasia, Vishal K. Singh, Richa Mishra, Piyush Kant Rai, Kamlesh Choure & Archana Pandey. (2022) Molecular modelling, DFT, molecular dynamics simulations, synthesis and antimicrobial potential studies of heterocyclic nucleoside mimetics. Journal of Molecular Structure, pages 134071.
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Mahender Thatikayala, Anil Kumar Garige & Hemalatha Gadegoni. 2022. Benzimidazole. Benzimidazole.
Remya R.S.. (2022) Design, Synthesis and Pharmacological Evaluation of Novel Benzimidazole Derivatives as Anticancer Agents. Current Bioactive Compounds 18:6.
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Parin Salim Sidat, Tasneem Mohamadbin Kasim Jaber, Shwetang Ramesh Vekariya, Azmin Mahervan Mogal, Aarifa Mustak Patel & Malleshappa Noolvi. (2022) Anticancer Biological Profile of Some Heterocylic Moieties-Thiadiazole, Benzimidazole, Quinazoline, and Pyrimidine. Pharmacophore 13:4, pages 59-71.
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Vishal K Singh, Himani Chaurasia, Richa Mishra, Ritika Srivastava, Farha Naaz, Pradeep Kumar & Ramendra K Singh. (2022) Docking, ADMET prediction, DFT analysis, synthesis, cytotoxicity, antibacterial screening and QSAR analysis of diarylpyrimidine derivatives. Journal of Molecular Structure 1247, pages 131400.
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Garvit Satija, Barkha Sharma, Anish Madan, Ashif Iqubal, Mohammad Shaquiquzzaman, Mymoona Akhter, Suhel Parvez, Mohammad Ahmed Khan & Mohammad Mumtaz Alam. (2021) Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets. Journal of Heterocyclic Chemistry 59:1, pages 22-66.
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Smita Bait, Suvidha Shinde, Ravindra Adivarekar & Nagaiyan Sekar. (2021) A study on multifunctional protein fibre with UV protection, moth repellency and antibacterial properties using ESIPT core containing benzimidazole and benzothiazole based functional acid azo dyes. Journal of the Indian Chemical Society 98:12, pages 100236.
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Shejuti Rahman Brishty, Md. Jamal Hossain, Mayeen Uddin Khandaker, Mohammad Rashed Iqbal Faruque, Hamid Osman & S. M. Abdur Rahman. (2021) A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives. Frontiers in Pharmacology 12.
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Lamia A. Siddig, Mohammad A. Khasawneh, Abdelouahid Samadi, Haythem Saadeh, Nael Abutaha & Mohammad Ahmed Wadaan. (2021) Synthesis of novel thiourea-/urea-benzimidazole derivatives as anticancer agents. Open Chemistry 19:1, pages 1062-1073.
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Łukasz Popiołek. (2021) Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones. International Journal of Molecular Sciences 22:17, pages 9389.
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K. R. Al-Jorani, A. J. K. Atia & R. I. Al-Bayti. (2021) Synthesis, Structure Elucidation, and Pharmacological Study of New Hydrazinylidene Derivatives Using Benzimidazole as a Scaffold. Russian Journal of Bioorganic Chemistry 47:4, pages 945-953.
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Deepa Parwani, Sushanta Bhattacharya, Akash Rathore, Chaitali Mallick, Vivek Asati, Shivangi Agarwal, Vaibhav Rajoriya, Ratnesh Das & Sushil Kumar Kashaw. (2021) Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives. Mini-Reviews in Medicinal Chemistry 21:5, pages 643-657.
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Laxmi Deswal, Vikas Verma, Devinder Kumar, Chander P. Kaushik, Ashwani Kumar, Yogesh Deswal & Suman Punia. (2020) Synthesis and antidiabetic evaluation of benzimidazole‐tethered 1,2,3‐triazoles. Archiv der Pharmazie 353:9, pages 2000090.
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Martha M. Morcoss, El Shimaa M.N. Abdelhafez, Reham A. Ibrahem, Hamdy M. Abdel-Rahman, Mohamed Abdel-Aziz & Dalal A. Abou El-Ella. (2020) Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents. Bioorganic Chemistry 101, pages 103956.
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Wang Haoran, Wasim Akhtar, Lalit Mohan Nainwal, Sumit Kumar Kaushik, Mymoona Akhter, Mohammad Shaquiquzzaman & Mohammad Mumtaz Alam. (2020) Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents. Journal of Heterocyclic Chemistry.
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Snehlata Yadav & Balasubramanian Narasimhan. (2020) New Insights in Design and Development of Antitubercular Drugs. Current Bioactive Compounds 16:1, pages 13-23.
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Biswa Mohan Sahoo, Bimal Krishna Banik, Arun Kumar Mahato, C. Nithya Shanthi & Bibhash C. Mohantad. 2020. Green Approaches in Medicinal Chemistry for Sustainable Drug Design. Green Approaches in Medicinal Chemistry for Sustainable Drug Design 779 818 .
Sumit Tahlan, Sanjiv Kumar, Saloni Kakkar & Balasubramanian Narasimhan. (2019) Benzimidazole scaffolds as promising antiproliferative agents: a review. BMC Chemistry 13:1.
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Sumit Tahlan, Sanjiv Kumar & Balasubramanian Narasimhan. (2019) Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review. BMC Chemistry 13:1.
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Senem Akkoç. (2019) Derivatives of 1‐(2‐(Piperidin‐1‐yl)ethyl)‐1 H ‐benzo[ d ]imidazole: Synthesis, Characterization, Determining of Electronic Properties and Cytotoxicity Studies . ChemistrySelect 4:17, pages 4938-4943.
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