Advanced search
Publication Cover
Emerging Microbes & Infections Volume 3, 2014 - Issue 1
Submit an article Journal homepage
1,310
Views
39
CrossRef citations to date
0
Altmetric
Original Articles

The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo

Peijun RenUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, 75013, Paris, France;Institut National de la Santé et de la Recherche Médicale, U1108 & Viral Pathogenesis Unit, Department of Virology, Institut Pasteur, 75724 Paris, France
,
Gang ZouUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
,
Benjamin BaillyUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;Institute for Glycomics, Gold Coast Campus, Griffith University, 4222 Queensland, Australia
,
Shanshan XuUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
,
Mei ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai 201102, China
,
Xinsheng Chen State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131, China
,
Liang Shen State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131, China
,
Ying ZhangInstitute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, Yunnan Province, China
,
Patrice GuillonInstitute for Glycomics, Gold Coast Campus, Griffith University, 4222 Queensland, Australia
,
Fernando Arenzana-SeisdedosInstitut National de la Santé et de la Recherche Médicale, U1108 & Viral Pathogenesis Unit, Department of Virology, Institut Pasteur, 75724 Paris, France
,
Philippe BuchyVirology Unit, Institut Pasteur in Cambodia, 12201 Phnom Penh, Cambodia
,
Jian Li State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131, China
,
Mark von ItzsteinInstitute for Glycomics, Gold Coast Campus, Griffith University, 4222 Queensland, Australia
,
Qihan LiInstitute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, Yunnan Province, China
&
Ralf AltmeyerUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, ChinaCorrespondence[email protected]
 show all
Pages 1-9 | Received 23 Sep 2015, Accepted 02 Nov 2015, Published online: 25 Jan 2019

Citations (39)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Guolan Wu, Huili Zhou, Duo Lv, Ruling Zheng, Lihua Wu, Songxia Yu, Jiejing Kai, Nana Xu, Lie Gu, Nanfang Hong & Jianzhong Shentu. (2023) Phase I, Single-Dose Study to Assess the Pharmacokinetics and Safety of Suramin in Healthy Chinese Volunteers. Drug Design, Development and Therapy 17, pages 2051-2061.
Read now
Tao Yang, Si Chun Wang, Linyan Ye, Yasen Maimaitiyiming & Hua Naranmandura. (2023) Targeting viral proteins for restraining SARS-CoV-2: focusing lens on viral proteins beyond spike for discovering new drug targets. Expert Opinion on Drug Discovery 18:3, pages 247-268.
Read now
Sandro G. Viveiros Rosa, Iolanda M. Fierro & Wilson C. Santos. (2020) Repositioning and investigational drugs for Zika virus infection treatment: a patent review. Expert Opinion on Therapeutic Patents 30:11, pages 847-862.
Read now
Ze Qin Lim, Qing Yong Ng, Justin Wei Qing Ng, Vikneswari Mahendran & Sylvie Alonso. (2020) Recent progress and challenges in drug development to fight hand, foot and mouth disease. Expert Opinion on Drug Discovery 15:3, pages 359-371.
Read now

Articles from other publishers (35)

Rui Yu, Xiaohong Li, Peng Zhang, Minghao Xu, Jitong Zhao, Jingjing Yan, Chenli Qiu, Jiayi Shu, Shuo Zhang, Miaomiao Kang, Xiaoyan Zhang, Jianqing Xu & Shuye Zhang. (2024) Integration of HiBiT into enteroviruses: A universal tool for advancing enterovirus virology research. Virologica Sinica.
Crossref
Shiraz Feferbaum-Leite, Igor Andrade Santos, Victória Riquena Grosche, Gislaine Celestino Dutra da Silva & Ana Carolina Gomes Jardim. (2023) Insights into enterovirus a-71 antiviral development: from natural sources to synthetic nanoparticles. Archives of Microbiology 205:10.
Crossref
Movin Abeywickrema, Dominic Kelly & Seilesh Kadambari. (2023) Management of neonatal central nervous system viral infections: Knowledge gaps and research priorities. Reviews in Medical Virology 33:2.
Crossref
Ran Yan, Jiahao He, Ge Liu, Jianfeng Zhong, Jiapeng Xu, Kai Zheng, Zhe Ren, Zhendan He & Qinchang Zhu. (2022) Drug Repositioning for Hand, Foot, and Mouth Disease. Viruses 15:1, pages 75.
Crossref
Annelies Van Den Bergh, Benjamin Bailly, Patrice Guillon, Mark von Itzstein & Larissa Dirr. (2022) Antiviral strategies against human metapneumovirus: Targeting the fusion protein. Antiviral Research 207, pages 105405.
Crossref
Madhu Khanna & Tanusri Nandi. (2022) Anti-viral activity of suramin against influenza A virus in A549 cells. Indian Journal of Microbiology Research 9:3, pages 190-194.
Crossref
Alexander K. C. Leung, Joseph M. Lam, Benjamin Barankin, Kin Fon Leong & Kam Lun Hon. (2022) Hand, Foot, and Mouth Disease: A Narrative Review. Recent Advances in Inflammation & Allergy Drug Discovery 16:2, pages 77-95.
Crossref
Kachaporn Jintana, Jarunee Prasertsopon, Pilaipan Puthavathana & Hatairat Lerdsamran. (2022) Antiviral effect in association with anti-apoptosis and anti-autophagy of repurposing formoterol fumarate dihydrate on enterovirus A71-infected neuronal cells. Virus Research 311, pages 198692.
Crossref
Jun Wang, Yanmei Hu & Madeleine Zheng. (2022) Enterovirus A71 antivirals: Past, present, and future. Acta Pharmaceutica Sinica B 12:4, pages 1542-1566.
Crossref
Sundy N. Y. Yang, Belinda Maher, Chunxiao Wang, Kylie M. Wagstaff, Johanna E. Fraser & David A. Jans. (2022) High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses. Cells 11:4, pages 730.
Crossref
Mohd Ishtiaq Anasir, Faisal Zarif & Chit Laa Poh. (2021) Antivirals blocking entry of enteroviruses and therapeutic potential. Journal of Biomedical Science 28:1.
Crossref
Yuan Fang, Zezhong Liu, Yang Qiu, Jing Kong, Yuhong Fu, Yujie Liu, Chong Wang, Jia Quan, Qian Wang, Wei Xu, Lei Yin, Jie Cui, Yi Xu, Stephen Curry, Shibo Jiang, Lu Lu & Xi Zhou. (2021) Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo. Immunity 54:10, pages 2231-2244.e6.
Crossref
Lei Wang, Yuzhu Dai, Jun Cheng, Changgui Sun, Yu Chen & Dawei Cui. (2021) Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China. Canadian Journal of Infectious Diseases and Medical Microbiology 2021, pages 1-14.
Crossref
John F.X. Diffley. (2021) Author's overview: identifying SARS-CoV-2 antiviral compounds. Biochemical Journal 478:13, pages 2533-2535.
Crossref
Jingkun ZengFlorian WeissmannAgustina P. BertolinViktor PosseBerta CanalRachel UlfertsMary WuRuth HarveySaira HussainJennifer C. MilliganChloe RoustanAnnabel BorgLaura McCoyLucy S. DrurySvend KjaerJohn McCauleyMichael HowellRupert BealeJohn F.X. Diffley. (2021) Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase. Biochemical Journal 478:13, pages 2405-2423.
Crossref
Han Kang Tee, Mohd Izwan Zainol, I-Ching Sam & Yoke Fun Chan. (2021) Recent advances in the understanding of enterovirus A71 infection: a focus on neuropathogenesis. Expert Review of Anti-infective Therapy 19:6, pages 733-747.
Crossref
Benjamin Bailly, Anil K. Gorle, Larissa Dirr, Alpeshkumar K. Malde, Nicholas P. Farrell, Susan J. Berners-Price & Mark von Itzstein. (2021) Platinum complexes act as shielding agents against virus infection. Chemical Communications 57:38, pages 4666-4669.
Crossref
Wanchao Yin, Xiaodong Luan, Zhihai Li, Ziwei Zhou, Qingxing Wang, Minqi Gao, Xiaoxi Wang, Fulai Zhou, Jingjing Shi, Erli You, Mingliang Liu, Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao, Leike Zhang, Xuekui Yu, Shuyang Zhang & H. Eric Xu. (2021) Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nature Structural & Molecular Biology 28:3, pages 319-325.
Crossref
Alexandra Y. Soare, Tracey L. Freeman, Alice K. Min, Hagerah S. Malik, Elizabeth O. Osota & Talia H. Swartz. (2021) P2RX7 at the Host-Pathogen Interface of Infectious Diseases. Microbiology and Molecular Biology Reviews 85:1.
Crossref
Nadia Abubakar Omar Abubakar Bajaber & Babu Ramanathan. 2021. Antimicrobial Therapies. Antimicrobial Therapies 167 184 .
Zhihui Li, Bin Cui, Xiaowen Liu, Laicheng Wang, Qingjie Xian, Zhaoxi Lu, Shuntao Liu, Yinguang Cao & Yueran Zhao. (2020) Virucidal activity and the antiviral mechanism of acidic polysaccharides against Enterovirus 71 infection in vitro . Microbiology and Immunology 64:3, pages 189-201.
Crossref
Natalie Wiedemar, Dennis A. Hauser & Pascal Mäser. (2020) 100 Years of Suramin. Antimicrobial Agents and Chemotherapy 64:3.
Crossref
Tao Meng, Qiang Jia, Sek-Man Wong & Kaw-Bing Chua. (2019) In Vitro and In Vivo Inhibition of the Infectivity of Human Enterovirus 71 by a Sulfonated Food Azo Dye, Brilliant Black BN . Journal of Virology 93:17.
Crossref
Baz & Boivin. (2019) Antiviral Agents in Development for Zika Virus Infections. Pharmaceuticals 12:3, pages 101.
Crossref
Jessica L. Kublin & James B. Whitney. (2018) Zika virus research models. Virus Research 254, pages 15-20.
Crossref
Chee Wah Tan, I-Ching Sam, Wei Lim Chong, Vannajan Sanghiran Lee & Yoke Fun Chan. (2017) Polysulfonate suramin inhibits Zika virus infection. Antiviral Research 143, pages 186-194.
Crossref
Irina C. Albulescu, Kristina Kovacikova, Ali Tas, Eric J. Snijder & Martijn J. van Hemert. (2017) Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles. Antiviral Research 143, pages 230-236.
Crossref
Peijun Ren, Yimei Zheng, Wenqi Wang, Liping Hong, Françis Delpeyroux, Fernando Arenzana-Seisdedos & Ralf Altmeyer. (2017) Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A. Scientific Reports 7:1.
Crossref
Szu-Cheng Kuo, Yu-Ming Wang, Yi-Jung Ho, Tein-Yao Chang, Zheng-Zong Lai, Pei-Yi Tsui, Tzong-Yuan Wu & Chang-Chi Lin. (2016) Suramin treatment reduces chikungunya pathogenesis in mice. Antiviral Research 134, pages 89-96.
Crossref
Yizhuo Wang, Guiming Li, Shilin Yuan, Qianqian Gao, Ke Lan, Ralf Altmeyer & Gang Zou. (2016) In Vitro Assessment of Combinations of Enterovirus Inhibitors against Enterovirus 71 . Antimicrobial Agents and Chemotherapy 60:9, pages 5357-5367.
Crossref
Shilin Yuan, Guiming Li, Ying Wang, Qianqian Gao, Yizhuo Wang, Rui Cui, Ralf Altmeyer & Gang Zou. (2016) Identification of Positively Charged Residues in Enterovirus 71 Capsid Protein VP1 Essential for Production of Infectious Particles. Journal of Virology 90:2, pages 741-752.
Crossref
Yorihiro Nishimura, Noel P. McLaughlin, Jieyan Pan, Sara Goldstein, Susan Hafenstein, Hiroyuki Shimizu, Jeffrey D. Winkler & Jeffrey M. Bergelson. (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLOS Pathogens 11:10, pages e1005184.
Crossref
Kien Chai Ong & Kum Thong Wong. (2015) Understanding Enterovirus 71 Neuropathogenesis and Its Impact on Other Neurotropic Enteroviruses. Brain Pathology 25:5, pages 614-624.
Crossref
Irina C. Albulescu, Marcella van Hoolwerff, Laura A. Wolters, Elisabetta Bottaro, Claudio Nastruzzi, Shih Chi Yang, Shwu-Chen Tsay, Jih Ru Hwu, Eric J. Snijder & Martijn J. van Hemert. (2015) Suramin inhibits chikungunya virus replication through multiple mechanisms. Antiviral Research 121, pages 39-46.
Crossref
Qianqian Gao, Shilin Yuan, Chao Zhang, Ying Wang, Yizhuo Wang, Guimei He, Shuyi Zhang, Ralf Altmeyer & Gang Zou. (2015) Discovery of Itraconazole with Broad-Spectrum In Vitro Antienterovirus Activity That Targets Nonstructural Protein 3A . Antimicrobial Agents and Chemotherapy 59:5, pages 2654-2665.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.