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Original Articles

Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis

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Pages 1-8 | Received 23 Sep 2015, Accepted 02 Nov 2015, Published online: 25 Jan 2019

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Muhammad Junaid, Cheng-Dong Li, Jiayi Li, Abbas Khan, Syed Shujait Ali, Syed Baber Jamal, Shah Saud, Arif Ali & Dong-Qing Wei. (2021) Structural insights of catalytic mechanism in mutant pyrazinamidase of Mycobacterium tuberculosis. Journal of Biomolecular Structure and Dynamics 39:9, pages 3172-3185.
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Gaurava Srivastava, M. P. Darokar & Ashok Sharma. (2020) Molecular investigation against the resistant mechanism of PncA mutated pyrazinamide resistance and insight into the role of pH environment for pyrazinamide activation. Journal of Biomolecular Structure and Dynamics 38:11, pages 3411-3431.
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Muhammad Tahir Khan & Shaukat Iqbal Malik. (2020) Structural dynamics behind variants in pyrazinamidase and pyrazinamide resistance. Journal of Biomolecular Structure and Dynamics 38:10, pages 3003-3017.
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HM Adnan Hameed, Yaoju Tan, Md Mahmudul Islam, Zhili Lu, Chiranjibi Chhotaray, Shuai Wang, Zhiyong Liu, Cuiting Fang, Shouyong Tan, Wing Wai Yew, Nanshan Zhong, Jianxiong Liu & Tianyu Zhang. (2020) Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China. Infection and Drug Resistance 13, pages 217-227.
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Patricia Bento da Silva, Débora Leite Campos, Camila Maríngolo Ribeiro, Isabel Cristiane da Silva & Fernando Rogério Pavan. (2017) New antimycobacterial agents in the pre-clinical phase or beyond: recent advances in patent literature (2001–2016). Expert Opinion on Therapeutic Patents 27:3, pages 269-282.
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Shuo Zhang, Jiazhen Chen, Wanliang Shi, Peng Cui, Jia Zhang, Sanghyun Cho, Wenhong Zhang & Ying Zhang. (2017) Mutation in clpC1 encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in Mycobacterium tuberculosis. Emerging Microbes & Infections 6:1, pages 1-2.
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Matthias Stehr, Ayssar A Elamin & Mahavir Singh. (2015) Pyrazinamide: the importance of uncovering the mechanisms of action in mycobacteria. Expert Review of Anti-infective Therapy 13:5, pages 593-603.
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Muhammad Tahir Khan, Elise Dumont, Aijaz Rasool Chaudhry & Dong-Qing Wei. Free energy landscape and thermodynamics properties of novel mutations in PncA of pyrazinamide resistance isolates of Mycobacterium tuberculosis. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
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