1,753
Views
83
CrossRef citations to date
0
Altmetric
Reviews

Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: molecular mechanisms and clinical significance

&
Pages 1-7 | Received 23 Sep 2015, Accepted 02 Nov 2015, Published online: 25 Jan 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Bulent Cakal, Alp Atasoy, Bilger Cavus, Mehves Poda, Mesut Bulakci, Mine Gulluoglu, Mehmet Demirci & Filiz Akyuz. (2022) Prevalence of Occult Hepatitis B Infection in Liver Biopsy Sample of Patients with Nonviral Liver Disease. Future Virology 17:10, pages 733-742.
Read now
Shang-Chin Huang, Hung-Chih Yang & Jia-Horng Kao. (2020) Hepatitis B reactivation: diagnosis and management. Expert Review of Gastroenterology & Hepatology 14:7, pages 565-578.
Read now
Christos Koutsianas, Konstantinos Thomas & Dimitrios Vassilopoulos. (2016) Prevention of HBV reactivation in patients treated with biologic agents. Expert Review of Clinical Pharmacology 9:4, pages 579-589.
Read now
Forough Golsaz-Shirazi & Fazel Shokri. (2016) Hepatitis B Immunopathogenesis and Immunotherapy. Immunotherapy 8:4, pages 461-477.
Read now
Sheikh Mohammad Fazle Akbar, Mamun Al-Mahtab, Munira Jahan, Osamu Yoshida & Yoichi Hiasa. (2016) Novel insights into immunotherapy for hepatitis B patients. Expert Review of Gastroenterology & Hepatology 10:2, pages 267-276.
Read now

Articles from other publishers (78)

Mayra Martínez-López, Claire Muslin & Nikolaos Kyriakidis. (2024) STINGing Defenses: Unmasking the Mechanisms of DNA Oncovirus-Mediated Immune Escape. Viruses 16:4, pages 574.
Crossref
Samuel Hofmann, Julius Luther, Verena Plank, Andreas Oswald, Julia Mai, Ilka Simons, Julija Miller, Valeria Falcone, Lea Hansen-Palmus, Hartmut Hengel, Michael Nassal, Ulrike Protzer & Sabrina Schreiner. (2024) Arsenic trioxide impacts hepatitis B virus core nuclear localization and efficiently interferes with HBV infection. Microbiology Spectrum.
Crossref
Robert Lam & Joseph K Lim. (2024) Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents. World Journal of Hepatology 16:3, pages 331-343.
Crossref
Guangjun Song, Ruifeng Yang, Qian Jin, Juan Liu, Huiying Rao, Bo Feng & Yandi Xie. (2023) HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients. BMC Gastroenterology 23:1.
Crossref
Ee Chee Ren, Nicole Ziyi Zhuo, Zhi Yi Goh, Isabelle Bonne, Benoît Malleret & Hui Ling Ko. (2023) cccDNA-Targeted Drug Screen Reveals a Class of Antihistamines as Suppressors of HBV Genome Levels. Biomolecules 13:10, pages 1438.
Crossref
Roberto Ponce-Pincay & Callejas Diana. (2023) Reactivación y coinfecciones virales en COVID-19: otro elemento a considerar. Revisión Sistemática. Kasmera 51.
Crossref
Siyi Xu, Jinlan Huang, Zhen Xun, Shiqi Li, Ya Fu, Ni Lin, Wennan Wu, Tianbin Chen, Can Liu & Qishui Ou. (2022) IFIT3 Is Increased in Serum from Patients with Chronic Hepatitis B Virus (HBV) Infection and Promotes the Anti-HBV Effect of Interferon Alpha via JAK-STAT2 In Vitro . Microbiology Spectrum.
Crossref
Yuan Zhang, Liang Li, Sheng-Tao Cheng, Yi-Ping Qin, Xin He, Fan Li, Dai-Qing Wu, Fang Ren, Hai-Bo Yu, Jing Liu, Juan Chen, Ji-Hua Ren & Zhen-Zhen Zhang. (2022) Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx. Frontiers in Microbiology 13.
Crossref
Mayuko Ide, Noriko Tabata, Yuko Yonemura, Takayoshi Shirasaki, Kazuhisa Murai, Ying Wang, Atsuya Ishida, Hikari Okada, Masao Honda, Shuichi Kaneko, Nobuhide Doi, Satoru Ito & Hiroshi Yanagawa. (2022) Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication. Journal of Biological Chemistry 298:7, pages 102097.
Crossref
Takehisa Watanabe, Sanae Hayashi & Yasuhito Tanaka. (2022) Drug Discovery Study Aimed at a Functional Cure for HBV. Viruses 14:7, pages 1393.
Crossref
Sevcan ATAY. (2022) Hepatit-B virüs ilişkili hepatosellüler karsinomda tümöral glipikan 3 mRNA seviyesinin diagnostik ve prognostik biyobelirteç olabilme potansiyelinin entegratif transkriptomik meta-analiz ve biyoinformatik ile değerlendirilmesiEvaluation of tumoral glypican 3 mRNA level as a diagnostic and prognostic biomarker for hepatitis-b virus-associated hepatocellular carcinoma by an integrative transcriptomic meta-analysis and bioinformatics. Ege Tıp Dergisi 61:2, pages 249-258.
Crossref
Caroline Holtkamp, Melanie Fiedler, Ulf Dittmer & Olympia E. Anastasiou. (2022) The Course of Anti-HBc Antibodies over Time in Immunocompromised Hosts. Vaccines 10:2, pages 137.
Crossref
Dylan Kairuz, Prashika Singh, Tiffany Smith, Patrick Arbuthnot, Abdullah Ely & Kristie Bloom. 2022. Messenger RNA Therapeutics. Messenger RNA Therapeutics 157 179 .
Yu-Chan Yang & Hung-Chih Yang. (2021) Recent Progress and Future Prospective in HBV Cure by CRISPR/Cas. Viruses 14:1, pages 4.
Crossref
Shang-Chin Huang & Jia-Horng Kao. (2021) Management of Hepatitis B in Persons Who Inject Drugs (PWID). Current Hepatology Reports 20:4, pages 158-165.
Crossref
Xiu-Mei Chi, Xiao-Mei Wang, Zhong-Feng Wang, Rui-Hong Wu, Xiu-Zhu Gao, Hong-Qin Xu, Yan-Hua Ding & Jun-Qi Niu. (2021) Serum hepatitis B core-related antigen as a surrogate marker of hepatitis B e antigen seroconversion in chronic hepatitis B. World Journal of Gastroenterology 27:40, pages 6927-6938.
Crossref
Takehisa Watanabe, Takako Inoue & Yasuhito Tanaka. (2021) Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B. Microorganisms 9:10, pages 2083.
Crossref
Meng‐Lan Wang, Juan Liao, Feng Ye, Ya‐Chao Tao, Dong‐Bo Wu, Min He, Hong Tang & En‐Qiang Chen. (2020) Distribution and factors associated with serum HBV pregenomic RNA levels in Chinese chronic hepatitis B patients. Journal of Medical Virology 93:6, pages 3688-3696.
Crossref
Sisi Yang, Xueqing Ma, Chengwei Cai, Huanqiu Wang, Fenqiang Xiao & Chengbo Yu. (2021) Tenofovir Disoproxil Fumarate Is Superior to Entecavir in Reducing Hepatitis B Surface Antigen for Chronic Hepatitis B in China: 2-Year Comprehensive Comparative Result of a Matched Comparative Study. Frontiers in Medicine 8.
Crossref
Tianxiang Lei, Fengbo Tan, Zhouhua Hou, Peng Liu, Xianhui Zhao & Heli Liu. (2021) Hepatitis B Virus Reactivation in Gastrointestinal Stromal Tumor Patients Treated With Imatinib. Frontiers in Oncology 10.
Crossref
Wei Lv, Tao Li, Shanshan Wang, Huihui Wang, Xuemei Li, Shubing Zhang, Lianzi Wang, Yuanhong Xu & Wei Wei. (2021) The Application of the CRISPR/Cas9 System in the Treatment of Hepatitis B Liver Cancer. Technology in Cancer Research & Treatment 20, pages 153303382110452.
Crossref
Vanessa Meier-Stephenson, Maulik D. Badmalia, Tyler Mrozowich, Keith C.K. Lau, Sarah K. Schultz, Darren L. Gemmill, Carla Osiowy, Guido van Marle, Carla S. Coffin & Trushar R. Patel. (2021) Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA. Journal of Biological Chemistry 296, pages 100589.
Crossref
K. M. Usychenko. (2020) Possibilities of predicting the rate of progression of liver fi brosis in patients with chronic hepatitis B. Clinical Medicine (Russian Journal) 98:5, pages 356-362.
Crossref
Robert G. Gish, Syed Abdul Basit, John Ryan, Altaf Dawood & Ulrike Protzer. (2020) Hepatitis B Core Antibody: Role in Clinical Practice in 2020. Current Hepatology Reports 19:3, pages 254-265.
Crossref
Yuichiro Yamamoto, Masatoshi Kakizaki, Takayuki Shimizu, Joaquim Carreras, Tetsuhiro Chiba, Kenji Chamoto, Tatehiro Kagawa, Taku Aoki, Naoya Nakamura, Kiyoshi Ando & Ai Kotani. (2020) PD-L1 is induced on the hepatocyte surface via CKLF-like MARVEL transmembrane domain-containing protein 6 up-regulation by the anti-HBV drug Entecavir. International Immunology 32:8, pages 519-531.
Crossref
Jinyu Sun, Jianchu Wang, Donghui Zheng & Xiaorong Hu. (2020) Advances in therapeutic application of CRISPR-Cas9. Briefings in Functional Genomics 19:3, pages 164-174.
Crossref
Fayed Attia Koutb Megahed, Xiaoling Zhou & Pingnan Sun. (2020) The Interactions Between HBV and the Innate Immunity of Hepatocytes. Viruses 12:3, pages 285.
Crossref
Man-Fung Yuen, Kosh Agarwal, Edward J Gane, Christian Schwabe, Sang Hoon Ahn, Dong Joon Kim, Young-Suk Lim, Wendy Cheng, William Sievert, Kumar Visvanathan, Eric Ruby, Sandy Liaw, Ran Yan, Qi Huang, Richard Colonno & Uri Lopatin. (2020) Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial. The Lancet Gastroenterology & Hepatology 5:2, pages 152-166.
Crossref
Ian Baudi, Takako Inoue & Yasuhito Tanaka. (2020) Novel Biomarkers of Hepatitis B and Hepatocellular Carcinoma: Clinical Significance of HBcrAg and M2BPGi. International Journal of Molecular Sciences 21:3, pages 949.
Crossref
Kristi L. Turton, Vanessa Meier-Stephenson, Maulik D. Badmalia, Carla S. Coffin & Trushar R. Patel. (2020) Host Transcription Factors in Hepatitis B Virus RNA Synthesis. Viruses 12:2, pages 160.
Crossref
M.G. Martinez, B. Testoni & F. Zoulim. 2020. Encyclopedia of Gastroenterology. Encyclopedia of Gastroenterology 122 127 .
Sergey Brezgin, Anastasiia Kostyusheva, Ekaterina Bayurova, Ilya Gordeychuk, Maria Isaguliants, Irina Goptar, Anastasiia Nikiforova, Valery Smirnov, Elena Volchkova, Dieter Glebe, Dmitry Kostyushev & Vladimir Chulanov. (2019) Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro. Microorganisms 7:11, pages 533.
Crossref
Ana Isabel Gil-García, Antonio Madejón, Irene Francisco-Recuero, Ana López-López, Emiliana Villafranca, Miriam Romero, Araceli García, Antonio Olveira, Rocío Mena, Juan Ramón Larrubia & Javier García-Samaniego. (2019) Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment. World Journal of Gastroenterology 25:38, pages 5883-5896.
Crossref
Tzu-Chan Hong, Hung-Chih Yang & Jia-Horng Kao. (2019) Role of HBsAg Testing in the Management of Patients with Chronic HBV. Current Hepatology Reports 18:3, pages 331-341.
Crossref
Uri Lopatin. (2019) Drugs in the Pipeline for HBV. Clinics in Liver Disease 23:3, pages 535-555.
Crossref
Maria G. Martinez, Barbara Testoni & Fabien Zoulim. (2019) Biological basis for functional cure of chronic hepatitis B. Journal of Viral Hepatitis 26:7, pages 786-794.
Crossref
Peter A Revill, Francis V Chisari, Joan M Block, Maura Dandri, Adam J Gehring, Haitao Guo, Jianming Hu, Anna Kramvis, Pietro Lampertico, Harry L A Janssen, Massimo Levrero, Wenhui Li, T Jake Liang, Seng-Gee Lim, Fengmin Lu, M Capucine Penicaud, John E Tavis, Robert Thimme, Fabien Zoulim, Patrick Arbuthnot, Andre Boonstra, Kyong-Mi Chang, Per-Jei Chen, Dieter Glebe, Luca G. Guidotti, Jacques Fellay, Carlo Ferrari, Louis Jansen, Daryl T Y Lau, Anna S Lok, Mala K Maini, William Mason, Gail Matthews, Dimitrios Paraskevis, Jörg Petersen, Barbara Rehermann, Eui-Cheol Shin, Alex Thompson, Florian van Bömmel, Fu-Sheng Wang, Koichi Watashi, Hung-Chih Yang, Zhenghong Yuan, Man-Fung Yuen, Timothy Block, Veronica Miller, Ulrike Protzer, Christian Bréchot, Stephen Locarnini, Marion G Peters & Raymond F Schinazi. (2019) A global scientific strategy to cure hepatitis B. The Lancet Gastroenterology & Hepatology 4:7, pages 545-558.
Crossref
In Moon, Jae Choi, Jung Chung, Eun Jang, Sook‑Hyang Jeong & Jin‑Wook Kim. (2019) MicroRNA‑20 induces methylation of hepatitis B virus covalently closed circular DNA in human hepatoma cells. Molecular Medicine Reports.
Crossref
Takako Inoue & Yasuhito Tanaka. (2019) The Role of Hepatitis B Core-Related Antigen. Genes 10:5, pages 357.
Crossref
En‐Qiang Chen, Meng‐Lan Wang, Ya‐Chao Tao, Dong‐Bo Wu, Juan Liao, Min He & Hong Tang. (2019) Serum HB crAg is better than HBV RNA and HB sAg in reflecting intrahepatic covalently closed circular DNA . Journal of Viral Hepatitis 26:5, pages 586-595.
Crossref
Hao Liu, Yang Wu, Fang He, Ziyuan Cheng, Zilu Zhao, Cuifang Xiang, Xiaoyu Feng, Xin Bai, Shunichi Takeda, Xiaohua Wu & Yong Qing. (2019) Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage. International Journal of Molecular Medicine.
Crossref
A. P. Kostyusheva, S. A. Brezgin, D. N. Zarifyan, D. S. Chistyakov, V. I. Gegechkory, E O. Bayurova, E. A. Volchkova, D. S. Kostyushev & V. P. Chulanov. (2019) Hepatitis B virus and site-specific nucleases: effects of genetic modifications in CRISPR/Cas9 on antiviral activity. Russian Journal of Infection and Immunity 9:2, pages 279-287.
Crossref
Carla S. Coffin, Kali Zhou & Norah A. Terrault. (2019) New and Old Biomarkers for Diagnosis and Management of Chronic Hepatitis B Virus Infection. Gastroenterology 156:2, pages 355-368.e3.
Crossref
Maria C. Leoni, Andrew Ustianowski, Hamzah Farooq & Joop E. Arends. (2018) HIV, HCV and HBV: A Review of Parallels and Differences. Infectious Diseases and Therapy 7:4, pages 407-419.
Crossref
Vanessa Meier-Stephenson, William Bremner, Chimone Dalton, Guido van Marle, Carla Coffin & Trushar Patel. (2018) Comprehensive Analysis of Hepatitis B Virus Promoter Region Mutations. Viruses 10:11, pages 603.
Crossref
Ashish Goyal & Ranjit Chauhan. (2018) The dynamics of integration, viral suppression and cell-cell transmission in the development of occult Hepatitis B virus infection. Journal of Theoretical Biology 455, pages 269-280.
Crossref
Emilia Hadziyannis & Andreas Laras. (2018) Viral Biomarkers in Chronic HBeAg Negative HBV Infection. Genes 9:10, pages 469.
Crossref
Bobin Hu, Rongming Wang, Jiaxin Fu, Minghua Su, Man Du, Yu Liu, Huijiao Li, Huiwen Wang, Fengmin Lu & Jianning Jiang. (2018) Integration of hepatitis B virus S gene impacts on hepatitis B surface antigen levels in patients with antiviral therapy. Journal of Gastroenterology and Hepatology 33:7, pages 1389-1396.
Crossref
Q. M. Nhu & P. J. Pockros. (2018) Editorial: chronic hepatitis B combination therapy—emerging success as proof‐of‐concept for future hepatitis B eradication?. Alimentary Pharmacology & Therapeutics 47:11, pages 1560-1561.
Crossref
Shrihari A. Anikhindi, Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal & Anil Arora. (2018) Ideal Cure for Hepatitis B Infection: The Target is in Sight. Journal of Clinical and Experimental Hepatology 8:2, pages 188-194.
Crossref
Carolina González, David Tabernero, Maria Francesca Cortese, Josep Gregori, Rosario Casillas, Mar Riveiro-Barciela, Cristina Godoy, Sara Sopena, Ariadna Rando, Marçal Yll, Rosa Lopez-Martinez, Josep Quer, Rafael Esteban, Maria Buti & Francisco Rodríguez-Frías. (2018) Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy. World Journal of Gastroenterology 24:19, pages 2095-2107.
Crossref
Ankur Jindal, Ashish Kumar Vyas, Devesh Kumar, Guresh Kumar, Manoj Kumar Sharma & Shiv Kumar Sarin. (2018) Higher efficacy of pegylated interferon‐α2b add‐on therapy in hepatitis B envelope antigen‐positive chronic hepatitis B patients on tenofovir monotherapy. Hepatology Research 48:6, pages 451-458.
Crossref
Vanita Uppada, Mahesh Gokara & Girish Kumar Rasineni. (2018) Diagnosis and therapy with CRISPR advanced CRISPR based tools for point of care diagnostics and early therapies. Gene 656, pages 22-29.
Crossref
Ranjit Chauhan, Shilpa Lingala, Chiranjeevi Gadiparthi, Nivedita Lahiri, Smruti R Mohanty, Jian Wu, Tomasz I Michalak & Sanjaya K Satapathy. (2018) Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management. World Journal of Hepatology 10:3, pages 352-370.
Crossref
Hadi Peeridogaheh, Zahra Meshkat, Shahram Habibzadeh, Mohsen Arzanlou, Jafar Mohammad Shahi, Sina Rostami, Sina Gerayli & Roghayeh Teimourpour. (2018) Current concepts on immunopathogenesis of hepatitis B virus infection. Virus Research 245, pages 29-43.
Crossref
Wen-xiong Xu, Qian Zhang, Xiang Zhu, Chao-shuang Lin, You-ming Chen, Hong Deng, Yong-yu Mei, Zhi-xin Zhao, Dong-ying Xie, Zhi-liang Gao, Chan Xie & Liang Peng. (2018) 48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse. Canadian Journal of Gastroenterology and Hepatology 2018, pages 1-11.
Crossref
Hung-Chih Yang & Pei-Jer Chen. (2018) The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA. Virus Research 244, pages 304-310.
Crossref
Jing Wang, Yiqi Yu, Guojun Li, Chuan Shen, Zhefeng Meng, Jianming Zheng, Yanhong Jia, Shaolong Chen, Xiao Zhang, Mengqi Zhu, Jiangjiang Zheng, Zhangzhang Song, Jing Wu, Lingyun Shao, Peiyu Qian, Xiaona Mao, Xuanyi Wang, Yuxian Huang, Caiyan Zhao, Jiming Zhang, Chao Qiu & Wenhong Zhang. (2018) Relationship between serum HBV-RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients. Journal of Hepatology 68:1, pages 16-24.
Crossref
Jingwu Dong, Jie Ying, Xiaoyan Qiu, Yu Lu & Miaomiao Zhang. (2017) Advanced Strategies for Eliminating the cccDNA of HBV. Digestive Diseases and Sciences 63:1, pages 7-15.
Crossref
Vanja Ničković, Radoslav Katanić, Nataša Katanić & Ilija Kocić. (2017) CHRONIC HEPATITIS B. Acta Medica Medianae 56:4, pages 50-60.
Crossref
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu & Ningshao Xia. (2017) Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide analogs. Frontiers of Medicine 11:4, pages 502-508.
Crossref
Tung-Hung Su & Jia-Horng Kao. (2017) Unmet Needs in Clinical and Basic Hepatitis B Virus Research. The Journal of Infectious Diseases 216:suppl_8, pages S750-S756.
Crossref
D S Kostyushev, A P Zueva, S A Brezgin, A D Lipatnikov, V N Simirskii, D Glebe, E V Volchkova, G A Shipulin & V P Chulanov. (2017) Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B. Terapevticheskii arkhiv 89:11, pages 21-26.
Crossref
Kai O. Hensel, Julio C. Rendon, Maria‐Cristina Navas, Marianne G. Rots & Jan Postberg. (2017) Virus–host interplay in hepatitis B virus infection and epigenetic treatment strategies. The FEBS Journal 284:21, pages 3550-3572.
Crossref
Bram Vrancken, Marc A Suchard & Philippe Lemey. (2017) Accurate quantification of within- and between-host HBV evolutionary rates requires explicit transmission chain modelling. Virus Evolution 3:2.
Crossref
En-Qiang Chen, Shu Feng, Meng-Lan Wang, Ling-Bo Liang, Ling-Yun Zhou, Ling-Yao Du, Li-Bo Yan, Chuan-Min Tao & Hong Tang. (2017) Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B. Scientific Reports 7:1.
Crossref
Ching-Lung Lai, Danny Wong, Philip Ip, Malgorzata Kopaniszen, Wai-Kay Seto, James Fung, Fung-Yu Huang, Brian Lee, Giuseppe Cullaro, Chun Kong Chong, Ringo Wu, Charles Cheng, John Yuen, Vincent Ngai & Man-Fung Yuen. (2017) Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B. Journal of Hepatology 66:2, pages 275-281.
Crossref
Maëlle Locatelli & Barbara Testoni. (2017) Analyse des événements virologiques intrahépatiques d’une infection chronique par le virus de l’hépatite B. médecine/sciences 33:1, pages 92-95.
Crossref
Sumedha Bagga, Siddhartha Rawat, Marcia Ajenjo & Michael J. Bouchard. (2016) Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication. Virology 498, pages 9-22.
Crossref
C.‐L. Lin & J.‐H. Kao. (2016) Review article: novel therapies for hepatitis B virus cure – advances and perspectives. Alimentary Pharmacology & Therapeutics 44:3, pages 213-222.
Crossref
Wei Zhu, Kun Xie, Yuanjian Xu, Le Wang, Kaiming Chen, Longzhen Zhang & Jianmin Fang. (2016) CRISPR/Cas9 produces anti-hepatitis B virus effect in hepatoma cells and transgenic mouse. Virus Research 217, pages 125-132.
Crossref
Chih‐Lin Lin, Hung‐Chih Yang & Jia‐Horng Kao. (2016) Hepatitis B virus: new therapeutic perspectives. Liver International 36:S1, pages 85-92.
Crossref
Jia-Horng Kao. (2015) Hepatitis B vaccination and prevention of hepatocellular carcinoma. Best Practice & Research Clinical Gastroenterology 29:6, pages 907-917.
Crossref
HONGYU JIA, CHANGHONG LIU, YING YANG, HAIHONG ZHU, FENG CHEN, JIHONG LIU & LINFU ZHOU. (2015) Inhibition of duck hepatitis B virus replication by mimic peptides in vitro. Experimental and Therapeutic Medicine 10:5, pages 1697-1703.
Crossref
Cheng Peng, Mengji Lu & Dongliang Yang. (2015) CRISPR/Cas9-based tools for targeted genome editing and replication control of HBV. Virologica Sinica 30:5, pages 317-325.
Crossref
Natalia Freitas, Tetyana Lukash, Louise Rodrigues, Sam Litwin, Bhaskar V. Kallakury, Stephan Menne & Severin O. Gudima. (2015) Infection Patterns Induced in Naive Adult Woodchucks by Virions of Woodchuck Hepatitis Virus Collected during either the Acute or Chronic Phase of Infection. Journal of Virology 89:17, pages 8749-8763.
Crossref
Louise Rodrigues, Natalia Freitas, Bhaskar V. Kallakury, Stephan Menne & Severin O. Gudima. (2015) Superinfection with Woodchuck Hepatitis Virus Strain WHVNY of Livers Chronically Infected with Strain WHV7. Journal of Virology 89:1, pages 384-405.
Crossref
Chih‐Lin Lin, Tai‐Chung Tseng & Jia‐Horng Kao. (2014) What can we learn from hepatitis B virus clinical cohorts?. Liver International 35:s1, pages 91-99.
Crossref