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Emerging Microbes & Infections Volume 7, 2018 - Issue 1
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Original Articles

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway

Yazhou LinDepartment of Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina;Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina
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Yucheng JiaoDepartment of Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina;Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina
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Ye YuanDepartment of Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina;Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina
,
Zezhu ZhouDepartment of Orthopedics, Xinhua HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina
,
Yuehuan ZhengDepartment of Orthopedics, Ruijin Hospital NorthShanghai Jiaotong University School of Medicine200000ShanghaiChina
,
Jiaqi XiaoDepartment of Medical Microbiology and ParasitologyShanghai Jiaotong University School of Medicine200000ShanghaiChina
,
Changwei LiShanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-9324-4685
ORCID Icon,
Zhe ChenDepartment of Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina;Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChinaCorrespondence[email protected]
&
Peng CaoDepartment of Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChina;Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin HospitalShanghai Jiaotong University School of Medicine200000ShanghaiChinaCorrespondence[email protected]
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Pages 1-8 | Received 08 Jul 2017, Accepted 31 Oct 2017, Published online: 10 Jan 2018

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Yuxin Fan, Jingjing Chen, Meixiao Liu, Xin Xu, Yu Zhang, Peng Yue, Wenjing Cao, Zhenhua Ji, Xuan Su, Shiyuan Wen, Jing Kong, Guozhong Zhou, Bingxue Li, Yan Dong, Aihua Liu & Fukai Bao. (2022) Application of Droplet Digital PCR to Detection of Mycobacterium tuberculosis and Mycobacterium leprae Infections: A Narrative Review. Infection and Drug Resistance 15, pages 1067-1076.
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Wei Chen, Shaoguang Li & Feng Zhang. (2021) Role of lncRNA XIST/microRNA-19/PTEN network in autophagy of nucleus pulposus cells in intervertebral disc degeneration via the PI3K/Akt signaling pathway. Cell Cycle 20:17, pages 1629-1641.
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Huan Wang, Yifan Ding, Wei Zhang, Kang Wei, Yaping Pei, Chenming Zou, Chong Zhang, Jiahui Ding, Huang Fang & Songwei Tan. (2020) Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments. Drug Design, Development and Therapy 14, pages 921-931.
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Muluneh Ademe & Friehiwot Girma. (2020) Candida auris: From Multidrug Resistance to Pan-Resistant Strains. Infection and Drug Resistance 13, pages 1287-1294.
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Claus Manniche & S⊘ren O'Neill. (2019) New Insights Link Low-Virulent Disc Infections to the Etiology of Severe Disc Degeneration and Modic Changes. Future Science OA 5:5.
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Fang Yafeng, Shi Xinpeng, Wei Rong & Cui Guofeng. (2024) Omilancor mitigates the senescence of nucleus pulposus cells induced by DDP through targeting MAP2K6. Aging 16:6, pages 5050-5064.
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Chunyang Fan, Genglei Chu, Zilin Yu, Zhongwei Ji, Fanchen Kong, Lingye Yao, Jiale Wang, Dechun Geng, Xiexing Wu & Haiqing Mao. (2023) The role of ferroptosis in intervertebral disc degeneration. Frontiers in Cell and Developmental Biology 11.
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Xiaolong Chen, Shibao Lu, Neha Chopra, Peng Cui, Sitao Zhang, Rajpal Narulla & Ashish D. Diwan. (2023) The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review. JOR SPINE 6:2.
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Ok-Jin Park, A Reum Kim, Yoon Ju So, Jintaek Im, Hyun Jung Ji, Ki Bum Ahn, Ho Seong Seo, Cheol-Heui Yun & Seung Hyun Han. (2021) Induction of Apoptotic Cell Death by Oral Streptococci in Human Periodontal Ligament Cells. Frontiers in Microbiology 12.
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Xiaogang Bao, Zhenhua Wang, Qi Jia, Sibo Shen, Likang Wu, Qi Jiang, Changwei Li & Guohua Xu. (2021) HIF-1α-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP. Oxidative Medicine and Cellular Longevity 2021, pages 1-17.
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V.S. Shapovalov, M.A. Bystrytska, N.V. Dedukh & O.I. Balyk. (2021) Modic changes in the lumbar spine: histology, risk factors, clinical presentation and treatment. PAIN, JOINTS, SPINE 11:2, pages 86-95.
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Ho Yin Pekkle Lam, Meng-Jiun Lai, Ting-Yu Chen, Wen-Jui Wu, Shih-Yi Peng & Kai-Chih Chang. (2021) Therapeutic Effect of a Newly Isolated Lytic Bacteriophage against Multi-Drug-Resistant Cutibacterium acnes Infection in Mice. International Journal of Molecular Sciences 22:13, pages 7031.
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Holger Brüggemann, Llanos Salar-Vidal, Harald P. M. Gollnick & Rolf Lood. (2021) A Janus-Faced Bacterium: Host-Beneficial and -Detrimental Roles of Cutibacterium acnes. Frontiers in Microbiology 12.
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Erin C. Coscia, Nader S. Abutaleb, Bradley Hostetter, Mohamed N. Seleem, Gert J. Breur, Robyn R. McCain, Christa J. Crain, Ondrej Slaby, Manu N. Capoor, Andrew McDowell, Fahad S. Ahmed, Viju Vijayanpillai, Sanjeev K. Narayanan & Michael F. Coscia. (2021) Sheep as a Potential Model of Intradiscal Infection by the Bacterium Cutibacterium acnes. Veterinary Sciences 8:3, pages 48.
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Constance Mayslich, Philippe Alain Grange & Nicolas Dupin. (2021) Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors. Microorganisms 9:2, pages 303.
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Guoqing Tang, Xiaoguang Han, Zhijie Lin, Hongbin Qian, Bing Chen, Chengliang Zhou, Yong Chen & Weimin Jiang. (2021) Propionibacterium acnes Accelerates Intervertebral Disc Degeneration by Inducing Pyroptosis of Nucleus Pulposus Cells via the ROS-NLRP3 Pathway. Oxidative Medicine and Cellular Longevity 2021, pages 1-12.
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Laura Baumgartner, Karin Wuertz-Kozak, Christine L. Le Maitre, Francis Wignall, Stephen M. Richardson, Judith Hoyland, Carlos Ruiz Wills, Miguel A. González Ballester, Michael Neidlin, Leonidas G. Alexopoulos & Jérôme Noailly. (2021) Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research. International Journal of Molecular Sciences 22:2, pages 703.
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Bettina Schmid, Oliver Hausmann, Wolfgang Hitzl, Yvonne Achermann & Karin Wuertz-Kozak. (2020) The Role of Cutibacterium acnes in Intervertebral Disc Inflammation. Biomedicines 8:7, pages 186.
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Manu N. Capoor, Christof Birkenmaier, Jeffrey C. Wang, Andrew McDowell, Fahad S. Ahmed, Holger Brüggemann, Erin Coscia, David G. Davies, Soren Ohrt-Nissen, Assaf Raz, Filip Ruzicka, Jonathan E. Schmitz, Vincent A. Fischetti & Ondrej Slaby. (2019) A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue. European Spine Journal 28:12, pages 2951-2971.
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Yucheng Jiao, Yazhou Lin, Yuehuan Zheng, Ye Yuan, Zhe Chen & Peng Cao. (2019) The bacteria-positive proportion in the disc tissue samples from surgery: a systematic review and meta-analysis. European Spine Journal 28:12, pages 2941-2950.
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Guoqing Tang, Yong Chen, Ji Chen, Zhuo Wang & Weimin Jiang. (2019) Higher proportion of low‑virulence anaerobic bacterial infection in young patients with intervertebral disc herniation. Experimental and Therapeutic Medicine.
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Yazhou Lin, Hui Cong, Kewei Liu, Yucheng Jiao, Ye Yuan, Guoqing Tang, Yong Chen, Yuehuan Zheng, Jiaqi Xiao, Changwei Li, Zhe Chen & Peng Cao. (2019) Microbicidal Phagocytosis of Nucleus Pulposus Cells Against Staphylococcus aureus via the TLR2/MAPKs Signaling Pathway. Frontiers in Immunology 10.
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Claus Manniche & Søren O'Neill. (2019) New insights link low-virulent disc infections to the etiology of severe disc degeneration and Modic changes. Future Science OA.
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Yucheng Jiao, Ye Yuan, Yazhou Lin, Zezhu Zhou, Yuehuan Zheng, Wenjian Wu, Guoqing Tang, Yong Chen, Jiaqi Xiao, Changwei Li, Zhe Chen & Peng Cao. (2018) Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 through TLR2–NF-κB p65 pathway. Journal of Molecular Medicine 97:1, pages 25-35.
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M.M. Georgy, F. Vaida, M. Stern & K. Murphy. (2018) Association between Type 1 Modic Changes and Propionibacterium Acnes Infection in the Cervical Spine: An Observational Study . American Journal of Neuroradiology 39:9, pages 1764-1767.
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Yazhou Lin, Guoqing Tang, Yucheng Jiao, Ye Yuan, Yuehuan Zheng, Yong Chen, Jiaqi Xiao, Changwei Li, Zhe Chen & Peng Cao. (2018) Propionibacterium acnes Induces Intervertebral Disc Degeneration by Promoting iNOS/NO and COX-2/PGE 2 Activation via the ROS-Dependent NF- κ B Pathway . Oxidative Medicine and Cellular Longevity 2018, pages 1-12.
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