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Emerging Microbes & Infections Volume 7, 2018 - Issue 1
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Original Articles

A novel SigB(Q225P) mutation in Staphylococcus aureus retains virulence but promotes biofilm formation

Hui LiuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Weilong ShangDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Zhen HuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Ying ZhengDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Jizhen YuanDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Qiwen HuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Huagang PengDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Xinyu CaiDepartment of Emergency, Xinqiao HospitalThird Military Medical University400037 ChongqingChina
,
Li TanDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Shu LiDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Junmin ZhuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Ming LiDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Xiaomei HuDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChina
,
Renjie ZhouDepartment of Emergency, Xinqiao HospitalThird Military Medical University400037 ChongqingChina
,
Xiancai RaoDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChinaCorrespondence[email protected]
&
Yi YangDepartment of Microbiology, College of Basic Medical SciencesThird Military Medical University400038ChongqingChinaCorrespondence[email protected]
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Pages 1-12 | Received 17 Dec 2017, Accepted 19 Mar 2018, Published online: 25 Apr 2018

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Dickson Kofi Wiredu Ocansey, Sanhua Hang, Xinyi Yuan, Hua Qian, Mengjiao Zhou, Chinasa Valerie Olovo, Xu Zhang & Fei Mao. (2023) The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease. Gut Microbes 15:1.
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Lijun Xue, Yang Yizhi Chen, Zhiyun Yan, Wei Lu, Dong Wan & Huifeng Zhu. (2019) Staphyloxanthin: a potential target for antivirulence therapy. Infection and Drug Resistance 12, pages 2151-2160.
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Pan Mao, Yan Wang, Lin Gan, Lingyun Liu, Jinni Chen, Lingling Li, Hui Sun, Xia Luo & Changyun Ye. (2023) Large–scale genetic analysis and biological traits of two SigB factors in Listeria monocytogenes: lineage correlations and differential functions. Frontiers in Microbiology 14.
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Juan Chen, Yuhuan Lv, Weilong Shang, Yi Yang, Yuting Wang, Zhen Hu, Xiaonan Huang, Rong Zhang, Jizhen Yuan, Jingbin Huang & Xiancai Rao. (2023) Loaded delta-hemolysin shapes the properties of Staphylococcus aureus membrane vesicles. Frontiers in Microbiology 14.
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Dustin R. Long, Kelsi Penewit, Hsin-Yu Lo, Jared Almazan, Elizabeth A. Holmes, Andrew B. Bryan, Daniel J. Wolter, Janessa D. Lewis, Adam Waalkes & Stephen J. Salipante. (2023) In Vitro Selection Identifies Staphylococcus aureus Genes Influencing Biofilm Formation . Infection and Immunity 91:3.
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María Guadalupe Avila-Novoa, Oscar Alberto Solis-Velazquez, Pedro Javier Guerrero-Medina, Jean-Pierre González-Gómez, Berenice González-Torres, Noemí Yolanda Velázquez-Suárez, Liliana Martínez-Chávez, Nanci Edid Martínez-Gonzáles, Lucia De la Cruz-Color, Luz María Ibarra-Velázquez, Marco Antonio Cardona-López, Miguel Ángel Robles-García & Melesio Gutiérrez-Lomelí. (2022) Genetic and compositional analysis of biofilm formed by Staphylococcus aureus isolated from food contact surfaces. Frontiers in Microbiology 13.
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Hui Wang, Jiawei Shen, Chengfeng Zhu, Kai Ma, Mengcheng Fang, Bingbing Li, Wenhui Wang & Ting Xue. (2022) Antibiotics Resistance and Virulence of Staphylococcus aureus Isolates Isolated from Raw Milk from Handmade Dairy Retail Stores in Hefei City, China. Foods 11:15, pages 2185.
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Hui Wang, Xue Hou, Jiawei Shen, Wenhui Wang, Yingwang Ye, Jiangliu Yu & Ting Xue. (2022) Alternative sigma factor B reduces biofilm formation and stress response in milk-derived Staphylococcus aureus. LWT 162, pages 113515.
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Li Qiao, Yi Yang, Keting Zhu, Yifan Rao, Gang Li, Xiancai Rao, Ming Li & Renjie Zhou. (2022) The Q225P Mutation in SigB Promotes Membrane Vesicle Formation in Staphylococcus aureus. Current Microbiology 79:3.
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Li Tan, Yuyang Huang, Weilong Shang, Yi Yang, Huagang Peng, Zhen Hu, Yuting Wang, Yifan Rao, Qiwen Hu, Xiancai Rao, Xiaomei Hu, Ming Li, Kaisen Chen & Shu Li. (2022) Accessory Gene Regulator (agr) Allelic Variants in Cognate Staphylococcus aureus Strain Display Similar Phenotypes. Frontiers in Microbiology 13.
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Ziga Ude, Nils Flothkötter, Gerard Sheehan, Marian Brennan, Kevin Kavanagh & Celine J. Marmion. (2021) Multi-targeted metallo-ciprofloxacin derivatives rationally designed and developed to overcome antimicrobial resistance. International Journal of Antimicrobial Agents 58:6, pages 106449.
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N. Zaatout, A. Ayachi & M. Kecha. (2020) Staphylococcus aureus persistence properties associated with bovine mastitis and alternative therapeutic modalities . Journal of Applied Microbiology 129:5, pages 1102-1119.
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Carlos M. Suligoy, Rocío E. Díaz, Ana-Katharina Gehrke, Natalie Ring, Gonzalo Yebra, Joana Alves, Marisa I. Gómez, Sindy Wendler, J. Ross FITZGERALD, Lorena Tuchscherr, Bettina Löffler, Daniel O. Sordelli, Mariángeles Noto Llana & Fernanda R. Buzzola. (2020) Acapsular Staphylococcus aureus with a non-functional agr regains capsule expression after passage through the bloodstream in a bacteremia mouse model. Scientific Reports 10:1.
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Xiaoying Xie, Xiaoqiang Liu, Yanling Li, Ling Luo, Wenchang Yuan, Baiji Chen, Guoyan Liang, Rui Shen, Hongyu Li, Songyin Huang & Chaohui Duan. (2020) Advanced Glycation End Products Enhance Biofilm Formation by Promoting Extracellular DNA Release Through sigB Upregulation in Staphylococcus aureus. Frontiers in Microbiology 11.
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Yifan Rao, Weilong Shang, Yi Yang, Renjie Zhou & Xiancai Rao. (2020) Fighting Mixed-Species Microbial Biofilms With Cold Atmospheric Plasma. Frontiers in Microbiology 11.
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Helene Marbach, Katharina Mayer, Claus Vogl, Jean Y. H. Lee, Ian R. Monk, Daniel O. Sordelli, Fernanda R. Buzzola, Monika Ehling-Schulz & Tom Grunert. (2019) Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic activity and biofilm formation. Scientific Reports 9:1.
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Nicole L. Inniss, Gerd Prehna & Donald A. Morrison. (2019) The pneumococcal σX activator, ComW, is a DNA-binding protein critical for natural transformation. Journal of Biological Chemistry 294:29, pages 11101-11118.
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Weilong Shang, Yifan Rao, Ying Zheng, Yi Yang, Qiwen Hu, Zhen Hu, Jizhen Yuan, Huagang Peng, Kun Xiong, Li Tan, Shu Li, Junmin Zhu, Ming Li, Xiaomei Hu, Xuhu Mao & Xiancai Rao. (2019) β-Lactam Antibiotics Enhance the Pathogenicity of Methicillin-Resistant Staphylococcus aureus via SarA-Controlled Lipoprotein-Like Cluster Expression. mBio 10:3.
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Ying Zheng, Weilong Shang, Huagang Peng, Yifan Rao, Xia Zhao, Zhen Hu, Yi Yang, Qiwen Hu, Li Tan, Kun Xiong, Shu Li, Junmin Zhu, Xiaomei Hu, Renjie Zhou, Ming Li & Xiancai Rao. (2019) Virulence Determinants Are Required for Brain Abscess Formation Through Staphylococcus aureus Infection and Are Potential Targets of Antivirulence Factor Therapy. Frontiers in Microbiology 10.
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Miri K. Pannu, Deborah A. Hudman, Neil J. Sargentini & Vineet K. Singh. (2018) Role of SigB and Staphyloxanthin in Radiation Survival of Staphylococcus aureus. Current Microbiology 76:1, pages 70-77.
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