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Emerging Microbes & Infections Volume 7, 2018 - Issue 1

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Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding

Adriana OsickovaInstitute of Microbiology of the CAS, v.v.i.PragueCzech Republic;Faculty of Science, Charles UniversityPragueCzech Republic

Nataliya BalashovaDepartment of Pathology, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

Jiri MasinInstitute of Microbiology of the CAS, v.v.i.PragueCzech Republic

Miroslav SulcInstitute of Microbiology of the CAS, v.v.i.PragueCzech Republic;Faculty of Science, Charles UniversityPragueCzech Republic

Jana RoderovaInstitute of Microbiology of the CAS, v.v.i.PragueCzech Republic

Tomas WaldInstitute of Microbiology of the CAS, v.v.i.PragueCzech Republic;Department of Orofacial Sciences and Program in Craniofacial BiologyUniversity of CaliforniaSan FranciscoCAUSA

Angela C. BrownDepartment of Chemical and Biomolecular EngineeringLehigh UniversityBethlehemPAUSA

Evan KoufosDepartment of Chemical and Biomolecular EngineeringLehigh UniversityBethlehemPAUSA

En Hyung ChangDepartment of Chemical and Biomolecular EngineeringLehigh UniversityBethlehemPAUSA

Alexander GiannakakisDepartment of Pathology, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA;The Department of Cell and Molecular Biology at Karolinska InstitutetStockholmSweden

Edward T. LallyDepartment of Pathology, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

Radim OsickaInstitute of Microbiology of the CAS, v.v.i.PragueCzech RepublicCorrespondence[email protected]

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Pages 1-15 | Received 23 Aug 2018, Accepted 08 Oct 2018, Published online: 07 Nov 2018

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https://doi.org/10.1038/s41426-018-0179-x
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Ziang Li, Rani Baidoun & Angela C. Brown. (2024) Toxin-triggered liposomes for the controlled release of antibiotics to treat infections associated with the gram-negative bacterium, Aggregatibacter actinomycetemcomitans. Colloids and Surfaces B: Biointerfaces 238, pages 113870.
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Helena Ostolaza & Jone Amuategi. (2024) Membrane Interaction Characteristics of the RTX Toxins and the Cholesterol-Dependence of Their Cytolytic/Cytotoxic Activity. International Journal of Molecular Sciences 25:6, pages 3131.
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Raphael Joye, Vladimir L. Cousin, Iliona Malaspinas, Leonce Mwizerwa, Maya Bouhabib, Tomasz Nalecz, Tornike Sologashvili, Maurice Beghetti, Arnaud G. L’Huillier & Julie Wacker. (2024) Infective Endocarditis Due to Kingella kingae. Microorganisms 12:1, pages 164.
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Waheed Ur Rahman, Radovan Fiser & Radim Osicka. (2023) Kingella kingae RtxA toxin interacts with sialylated gangliosides. Microbial Pathogenesis 181, pages 106200.
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Feby M. Chacko & Lutz Schmitt. (2023) Interaction of RTX toxins with the host cell plasma membrane. Biological Chemistry 404:7, pages 663-671.
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Pablo Yagupsky. 2023. Principles and Practice of Pediatric Infectious Diseases. Principles and Practice of Pediatric Infectious Diseases 962 967.e3 .

Isabelle N. Erenburg, Sebastian Hänsch, Feby M. Chacko, Anna Hamacher, Sebastian Wintgens, Fabian Stuhldreier, Gereon Poschmann, Olivia Spitz, Kai Stühler, Sebastian Wesselborg, Johannes H. Hegemann, Sander H. J. Smits, Stefanie Weidtkamp-Peters & Lutz Schmitt. (2022) Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell. Scientific Reports 12:1.
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Eric A. Porsch, Kevin A. Hernandez, Daniel P. Morreale, Nina R. Montoya, Taylor A. Yount & Joseph W. St. GemeIIIIII. (2022) Pathogenic determinants of Kingella kingae disease. Frontiers in Pediatrics 10.
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Jone Amuategi, Rocío Alonso & Helena Ostolaza. (2022) Four Cholesterol-Recognition Motifs in the Pore-Forming and Translocation Domains of Adenylate Cyclase Toxin Are Essential for Invasion of Eukaryotic Cells and Lysis of Erythrocytes. International Journal of Molecular Sciences 23:15, pages 8703.
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Eric A. Porsch. (2022) Kingella kingae Virulence Factors and Insights into Pathogenicity. Microorganisms 10:5, pages 997.
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Katerina Filipi, Waheed Ur Rahman, Adriana Osickova & Radim Osicka. (2022) Kingella kingae RtxA Cytotoxin in the Context of Other RTX Toxins. Microorganisms 10:3, pages 518.
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Carmela Giglione & Thierry Meinnel. (2022) Mapping the myristoylome through a complete understanding of protein myristoylation biochemistry. Progress in Lipid Research 85, pages 101139.
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Ayelén Ivana Pesce Viglietti, Franco Agustín Sviercz, Cinthya Alicia Marcela López, Rosa Nicole Freiberger, Jorge Quarleri & María Victoria Delpino. (2021) Proinflammatory Microenvironment During Kingella kingae Infection Modulates Osteoclastogenesis. Frontiers in Immunology 12.
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David González Bullón, Kepa B. Uribe, Jone Amuategi, César Martín & Helena Ostolaza. (2021) Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size. The FEBS Journal 288:23, pages 6795-6814.
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Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo & Jiri Masin. (2021) Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins. Scientific Reports 11:1.
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Ashwath B, Adline Vadhana D, Anitha V & Shanmugam M. (2021) Aggregatibacter actinomycetemcomitans- A periodontopathogen. IP International Journal of Periodontology and Implantology 6:2, pages 61-67.
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Garrison Komaniecki & Hening Lin. (2021) Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function. Frontiers in Cell and Developmental Biology 9.
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Miao WangHening Lin. (2021) Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation. Annual Review of Biochemistry 90:1, pages 245-285.
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Jawid Nazir Ahmad & Peter Sebo. (2021) Bacterial RTX toxins and host immunity. Current Opinion in Infectious Diseases 34:3, pages 187-196.
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Waheed Ur Rahman, Adriana Osickova, Nela Klimova, Jinery Lora, Nataliya Balashova & Radim Osicka. (2020) Binding of Kingella kingae RtxA Toxin Depends on Cell Surface Oligosaccharides, but Not on β2 Integrins. International Journal of Molecular Sciences 21:23, pages 9092.
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Adriana Osickova, Humaira Khaliq, Jiri Masin, David Jurnecka, Anna Sukova, Radovan Fiser, Jana Holubova, Ondrej Stanek, Peter Sebo & Radim Osicka. (2020) Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins. Journal of Biological Chemistry 295:28, pages 9268-9280.
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Eric Krueger & Angela C. Brown. (2020) Aggregatibacter actinomycetemcomitans leukotoxin: From mechanism to targeted anti‐toxin therapeutics . Molecular Oral Microbiology 35:3, pages 85-105.
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Vanessa L Muñoz, Eric A Porsch & Joseph W St. GemeIIIIII. (2020) Virulence determinants of the emerging pathogen Kingella kingae. Current Opinion in Microbiology 54, pages 37-42.
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Edward T Lally, Kathleen Boesze-Battaglia, Anuradha Dhingra, Nestor M Gomez, Jinery Lora, Claire H Mitchell, Alexander Giannakakis, Syed A Fahim, Roland Benz & Nataliya Balashova. (2020) Aggregatibacter actinomycetemcomitans LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes. Pathogens 9:2, pages 74.
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Joachim Frey. (2019) RTX Toxins of Animal Pathogens and Their Role as Antigens in Vaccines and Diagnostics. Toxins 11:12, pages 719.
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Ondrej Stanek, Jiri Masin, Radim Osicka, David Jurnecka, Adriana Osickova & Peter Sebo. (2019) Rapid Purification of Endotoxin-Free RTX Toxins. Toxins 11:6, pages 336.
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Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding

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Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding

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