Advanced search
Publication Cover
Current Eye Research Volume 16, 1997 - Issue 9
Submit an article Journal homepage
95
Views
55
CrossRef citations to date
0
Altmetric
Research Article

Evaluation of recombinant adeno-associated virus as a gene transfer vector for the retina

Calvin A. Grant The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA and Departments of Medicine, Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
,
Selvarangan Ponnazhagan The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA and Departments of Medicine, Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
,
Xu-Shan Wang The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA and Departments of Medicine, Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
,
Arun Srivastava The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA and Departments of Medicine, Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
&
Tiansen Li The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA and Departments of Medicine, Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
Pages 949-956 | Published online: 02 Jul 2009

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Sheng-Hai Zhang*Ji-Hong Wu*Xiao-Bing Wu*Xiao-Yan Dong, Xin-Jian Liu & Chuan-Yuan Li. (2008) Distinctive Gene Transduction Efficiencies of Commonly Used Viral Vectors in the Retina. Current Eye Research 33:1, pages 81-90.
Read now
Wei-Chi Wu, Chi-Chun Lai, Show-Li Chen, Ming-Hui Sun, Xiao Xiao, Tun-Lu Chen, Ken-Kuo Lin, Shu-Wen Kuo & Yeou-Ping Tsao. (2005) Long-Term Safety of GDNF Gene Delivery in the Retina. Current Eye Research 30:8, pages 715-722.
Read now
Eliisa Mannermaa, Seppo Rönkkö, Marika Ruponen, Mika Reinisalo & Arto Urtti. (2005) Long-Lasting Secretion of Transgene Product from Differentiated and Filter-Grown Retinal Pigment Epithelial Cells After Nonviral Gene Transfer. Current Eye Research 30:5, pages 345-353.
Read now
Trevor J McFarland, Yi Zhang, Binoy Appukuttan & J Timothy Stout. (2004) Gene therapy for proliferative ocular diseases. Expert Opinion on Biological Therapy 4:7, pages 1053-1058.
Read now

Articles from other publishers (51)

Rachel Atkinson, Jacqueline Leung, James Bender, Matthew Kirkcaldie, James Vickers & Anna King. (2021) TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy. Disease Models & Mechanisms 14:2.
Crossref
Marianthi Karali, Irene Guadagnino, Elena Marrocco, Rossella De Cegli, Annamaria Carissimo, Mariateresa Pizzo, Simona Casarosa, Ivan Conte, Enrico Maria Surace & Sandro Banfi. (2020) AAV-miR-204 Protects from Retinal Degeneration by Attenuation of Microglia Activation and Photoreceptor Cell Death. Molecular Therapy - Nucleic Acids 19, pages 144-156.
Crossref
Elena Herrera-CarrilloYing Poi LiuBen Berkhout. (2017) Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors. Human Gene Therapy Methods 28:4, pages 177-190.
Crossref
Preethi SomasundaramGlenn R. WyrickDiego Carlos FernandezAlireza GhahariCindy M. PinhalMelissa Simmonds RichardsonAlan C. RuppLihong CuiZhijian WuR. Lane BrownTudor Constantin BadeaSamer Hattar & Phyllis R. Robinson. (2017) C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice. Proceedings of the National Academy of Sciences 114:10, pages 2741-2746.
Crossref
Sandy S.C. Hung, Tristan McCaughey, Olivia Swann, Alice Pébay & Alex W. Hewitt. (2016) Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease. Progress in Retinal and Eye Research 53, pages 1-20.
Crossref
Michelle E. McClements & Robert E. MacLaren. 2015. Translating Gene Therapy to the Clinic. Translating Gene Therapy to the Clinic 173 189 .
Michelle E. McClements & Robert E. MacLaren. (2013) Gene therapy for retinal disease. Translational Research 161:4, pages 241-254.
Crossref
Ying Poi Liu & Ben Berkhout. (2011) miRNA cassettes in viral vectors: Problems and solutions. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1809:11-12, pages 732-745.
Crossref
C Mussolino, M della Corte, S Rossi, F Viola, U Di Vicino, E Marrocco, S Neglia, M Doria, F Testa, R Giovannoni, M Crasta, M Giunti, E Villani, M Lavitrano, M L Bacci, R Ratiglia, F Simonelli, A Auricchio & E M Surace. (2011) AAV-mediated photoreceptor transduction of the pig cone-enriched retina. Gene Therapy 18:7, pages 637-645.
Crossref
Lauren E Mays & James M Wilson. (2011) The Complex and Evolving Story of T cell Activation to AAV Vector-encoded Transgene Products. Molecular Therapy 19:1, pages 16-27.
Crossref
Kati Kinnunen, Giedrius Kalesnykas, Anssi J. Mähönen, Svetlana Laidinen, Liisa Holma, Tommi Heikura, Kari Airenne, Hannu Uusitalo & Seppo Ylä‐Herttuala. (2009) Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus‐ and adenovirus‐mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye. The Journal of Gene Medicine 11:5, pages 382-389.
Crossref
M Natkunarajah, P Trittibach, J McIntosh, Y Duran, S E Barker, A J Smith, A C Nathwani & R R Ali. (2007) Assessment of ocular transduction using single-stranded and self-complementary recombinant adeno-associated virus serotype 2/8. Gene Therapy 15:6, pages 463-467.
Crossref
Inchan Kwon & David V. Schaffer. (2007) Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer. Pharmaceutical Research 25:3.
Crossref
Takao Hashimoto. 2008. Recent Advances in Retinal Degeneration. Recent Advances in Retinal Degeneration 113 119 .
Mariacarmela Allocca, Claudio Mussolino, Maria Garcia-Hoyos, Daniela Sanges, Carolina Iodice, Marco Petrillo, Luk H. Vandenberghe, James M. Wilson, Valeria Marigo, Enrico M. Surace & Alberto Auricchio. (2007) Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors. Journal of Virology 81:20, pages 11372-11380.
Crossref
Astra DinculescuLyudmyla GlushakovaSeok-Hong MinWilliam W. Hauswirth. (2005) Adeno-Associated Virus-Vectored Gene Therapy for Retinal Disease. Human Gene Therapy 16:6, pages 649-663.
Crossref
LINGYUN CHENG, MITSUKO TOYOGUCHI, DAVID J. LOONEY, JEFFERY LEE, MARIE C. DAVIDSON & WILLIAM R. FREEMAN. (2005) EFFICIENT GENE TRANSFER TO RETINAL PIGMENT EPITHELIUM CELLS WITH LONG-TERM EXPRESSION. Retina 25:2, pages 193-201.
Crossref
K R G Martin & H A Quigley. (2004) Gene therapy for optic nerve disease. Eye 18:11, pages 1049-1055.
Crossref
Anne K. Hennig, Judith Mosinger Ogilvie, Kevin K. Ohlemiller, Adrian M. Timmers, William W. Hauswirth & Mark S. Sands. (2004) AAV-mediated intravitreal gene therapy reduces lysosomal storage in the retinal pigmented epithelium and improves retinal function in adult MPS VII mice. Molecular Therapy 10:1, pages 106-116.
Crossref
Stefan Isenmann, Christian Schmeer & Alexandra Kretz. (2004) How to keep injured CNS neurons viable—strategies for neuroprotection and gene transfer to retinal ganglion cells. Molecular and Cellular Neuroscience 26:1, pages 1-16.
Crossref
Jie Zhang, Qing Shan, Ping Ma, Yanming Jiang, Peng Chen, Jingxia Wen, You Zhou, Huanwen Qian & Xuetao Pei. (2004) Differentiation potential of bone marrow mesenchymal stem cells into retina in normal and laser-injured rat eye. Science in China Series C: Life Sciences 47:3, pages 241-250.
Crossref
Wei-Yong Shen, Yvonne K.Y. Lai, Chooi-May Lai & P.Elizabeth Rakoczy. (2004) Impurity of recombinant adeno-associated virus type 2 affects the transduction characteristics following subretinal injection in the rat. Vision Research 44:4, pages 339-348.
Crossref
Andrew J. Lotery, Grace S. Yang, Robert F. Mullins, Stephen R. Russell, Michael Schmidt, Edwin M. Stone, Jonathan D. Lindbloom, John A. Chiorini, Robert M. Kotin & Beverly L. Davidson. (2003) Adeno-Associated Virus Type 5: Transduction Efficiency and Cell-Type Specificity in the Primate Retina. Human Gene Therapy 14:17, pages 1663-1671.
Crossref
Wei‐Yong Shen, Chooi‐May Lai, Yvonne K. Y. Lai, Dan Zhang, Tammy Zaknich, Erika N. Sutanto, Ian J. Constable & P. Elizabeth Rakoczy. (2003) Practical considerations of recombinant adeno‐associated virus‐mediated gene transfer for treatment of retinal degenerations. The Journal of Gene Medicine 5:7, pages 576-587.
Crossref
Alberto Auricchio. (2003) Pseudotyped AAV vectors for constitutive and regulated gene expression in the eye. Vision Research 43:8, pages 913-918.
Crossref
Joyce Tombran-Tink. 2003. Ophthalmic Drug Delivery Systems, Second Edition. Ophthalmic Drug Delivery Systems, Second Edition 535 608 .
Joel Gatlin, Michael W Melkus, Angela Padgett, W.Matthew Petroll, H.Dwight Cavanagh, J.Victor Garcia & James V Jester. (2003) In vivo fluorescent labeling of corneal wound healing fibroblasts. Experimental Eye Research 76:3, pages 361-371.
Crossref
P. Elizabeth Rakoczy, Chooi-May Lai, Meaghan J. T. Yu, Dru M. Daniels, Meliha Brankov, Ben C. Rae, Chris W. Stoddart, Nigel L. Barnett, Matthew T. Martin-Iverson, T. Michael Redmond, Kristina Narfstrom, Xiaohuai Zhou & Ian J. Constable. 2003. Retinal Degenerations. Retinal Degenerations 431 438 .
Thucanh T. Ho, Albert M. Maguire, Gustavo D. Aguirre, Enrico M. Surace, Vibha Anand, Yong Zeng, Anna Salvetti, John J. Hopwood, Mark E. Haskins & Jean Bennett. (2002) Phenotypic rescue after adeno‐associated virus‐mediated delivery of 4‐sulfatase to the retinal pigment epithelium of feline mucopolysaccharidosis VI. The Journal of Gene Medicine 4:6, pages 613-621.
Crossref
Keith R.G Martin, Ronald L Klein & Harry A Quigley. (2002) Gene delivery to the eye using adeno-associated viral vectors. Methods 28:2, pages 267-275.
Crossref
Edward Chaum & Mark P Hatton. (2002) Gene Therapy for Genetic and Acquired Retinal Diseases. Survey of Ophthalmology 47:5, pages 449-469.
Crossref
A.R. Harvey, W. Kamphuis, R. Eggers, N.A. Symons, B. Blits, S. Niclou, G.J. Boer & J. Verhaagen. (2002) Intravitreal Injection of Adeno-associated Viral Vectors Results in the Transduction of Different Types of Retinal Neurons in Neonatal and Adult Rats: A Comparison with Lentiviral Vectors. Molecular and Cellular Neuroscience 21:1, pages 141-157.
Crossref
Todd A. Derksen, Sybille L. Sauter & Beverly L. Davidson. (2002) Feline immunodeficiency virus vectors. Gene transfer to mouse retina following intravitreal injection. The Journal of Gene Medicine 4:5, pages 463-469.
Crossref
Grace S. Yang, Michael Schmidt, Ziying Yan, Jonathan D. Lindbloom, Thomas C. Harding, Brian A. Donahue, John F. Engelhardt, Robert Kotin & Beverly L. Davidson. (2002) Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size. Journal of Virology 76:15, pages 7651-7660.
Crossref
Alberto Auricchio, Victor M Rivera, Tim Clackson, Erin E O'Connor, Albert M Maguire, Michael J Tolentino, Jean Bennett & James M Wilson. (2002) Pharmacological Regulation of Protein Expression from Adeno-Associated Viral Vectors in the Eye. Molecular Therapy 6:2, pages 238-242.
Crossref
Li Cheng, Przemyslaw Sapieha, Pavla Kittlerová, William W. Hauswirth & Adriana Di Polo. (2002) TrkB Gene Transfer Protects Retinal Ganglion Cells from Axotomy-Induced Death In Vivo . The Journal of Neuroscience 22:10, pages 3977-3986.
Crossref
Andrew J. Lotery, Todd A. Derksen, Stephen R. Russell, Robert F. Mullins, Sybille Sauter, Louisa M. Affatigato, Edwin M. Stone & Beverly L. Davidson. (2002) Gene Transfer to the Nonhuman Primate Retina with Recombinant Feline Immunodeficiency Virus Vectors. Human Gene Therapy 13:6, pages 689-696.
Crossref
Henrik S Rasmussen, Camilla S Rasmussen, Rebecca G Durham, C.Richter King & Lisa Wei. (2001) Looking into anti-angiogenic gene therapies for disorders of the eye. Drug Discovery Today 6:22, pages 1171-1175.
Crossref
Nadine S. Dejneka & Jean Bennett. (2001) Gene therapy and retinitis pigmentosa: advances and future challenges. BioEssays 23:7, pages 662-668.
Crossref
Eric S. Green, Katherine G. Rendahl, Shangzhen Zhou, Martha Ladner, Mazie Coyne, Ranjana Srivastava, William C. Manning & John G. Flannery. (2001) Two Animal Models of Retinal Degeneration Are Rescued by Recombinant Adeno-associated Virus-Mediated Production of FGF-5 and FGF-18. Molecular Therapy 3:4, pages 507-515.
Crossref
R. L. Smith, D. L. Traul, J. Schaack, G. H. Clayton, K. J. Staley & C. L. Wilcox. (2000) Characterization of Promoter Function and Cell-Type-Specific Expression from Viral Vectors in the Nervous System. Journal of Virology 74:23, pages 11254-11261.
Crossref
Jean Bennett & Albert M. Maguire. (2000) Gene Therapy for Ocular Disease. Molecular Therapy 1:6, pages 501-505.
Crossref
Richard H. MaslandElio Raviola. (2000) Confronting Complexity: Strategies for Understanding the Microcircuitry of the Retina. Annual Review of Neuroscience 23:1, pages 249-284.
Crossref
Vibha Anand, Narendra Chirmule, Madeleine Fersh, Albert M. Maguire & Jean Bennett. (2000) Additional Transduction Events after Subretinal Readministration of Recombinant Adeno-Associated Virus. Human Gene Therapy 11:3, pages 449-457.
Crossref
Jean Bennett, Vibha Anand, Gregory M. Acland & Albert M. Maguire. 2000. Vertebrate Phototransduction and the Visual Cycle, Part B. Vertebrate Phototransduction and the Visual Cycle, Part B 777 789 .
Ronald L Klein, Ronald J Mandel & Nicholas Muzyczka. 2000. 507 528 .
Jean Bennett, Albert M. Maguire, Artur V. Cideciyan, Michael Schnell, Ernest Glover, Vibha Anand, Tomas S. Aleman, Narendra Chirmule, Abha R. Gupta, Yijun Huang, Guang-Ping Gao, William C. Nyberg, John Tazelaar, Joseph Hughes, James M. Wilson & Samuel G. Jacobson. (1999) Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina. Proceedings of the National Academy of Sciences 96:17, pages 9920-9925.
Crossref
Fabienne Rolling, Wei-Yong Shen, Hyacinth Tabarias, Ian Constable, Yogesan Kanagasingam, Chris J. Barry & Piroska E. Rakoczy. (1999) Evaluation of Adeno-Associated Virus-Mediated Gene Transfer into the Rat Retina by Clinical Fluorescence Photography. Human Gene Therapy 10:4, pages 641-648.
Crossref
Piroska E. Rakoczy, Wei-Yong Shen, May Lai, Fabienne Rolling & Ian J. Constable. (1999) Development of gene therapy-based strategies for the treatment of eye diseases. Drug Development Research 46:3-4, pages 277-285.
Crossref
Warren D. Lo, Guang Qu, Thomas J. Sferra, Reed Clark, Ruju Chen & Philip R. Johnson. (1999) Adeno-Associated Virus-Mediated Gene Transfer to the Brain: Duration and Modulation of Expression. Human Gene Therapy 10:2, pages 201-213.
Crossref
Stefan Isenmann, Nikolaj Klöcker, Claude Gravel & Mathias Bähr. (2003) Protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivo . European Journal of Neuroscience 10:8, pages 2751-2756.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.