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Current Eye Research Volume 17, 1998 - Issue 2
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Research Article

Beta adrenergic antagonist permeation across cultured rabbit corneal epithelial cells grown on permeable supports

Kouichi Kawazu Santen Pharmaceutical Co., Ltd. Ophthalmic Laboratories, Developmental Research Division and Product Development Center, Ikomo-shi, Japan
,
Hiromistu Shiono Santen Pharmaceutical Co., Ltd. Ophthalmic Laboratories, Developmental Research Division and Product Development Center, Ikomo-shi, Japan
,
Hidetoshi Tanioka Santen Pharmaceutical Co., Ltd. Ophthalmic Laboratories, Developmental Research Division and Product Development Center, Ikomo-shi, Japan
,
Atsutoshi Ota Santen Pharmaceutical Co., Ltd. Ophthalmic Laboratories, Developmental Research Division and Product Development Center, Ikomo-shi, Japan
,
Toshimi Ikuse Santen Pharmaceutical Co., Ltd. Ophthalmic Laboratories, Developmental Research Division and Product Development Center, Ikomo-shi, Japan
,
Hideo Takashina Santen Pharmaceutical Co., Ltd. Ophthalmic Laboratories, Developmental Research Division and Product Development Center, Ikomo-shi, Japan
&
Yoichi Kawashima Santen Pharmaceutical Co., Ltd. Ophthalmic Laboratories, Developmental Research Division and Product Development Center, Ikomo-shi, Japan
 show all
Pages 125-131 | Published online: 02 Jul 2009

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Ling Wang, Weixian Liu & Xionggao Huang. (2018) An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line. Libyan Journal of Medicine 13:1.
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Stephan Reichl, Christian Kölln, Matthias Hahne & Jessica Verstraelen. (2011) In vitro cell culture models to study the corneal drug absorption. Expert Opinion on Drug Metabolism & Toxicology 7:5, pages 559-578.
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Kumar G. Janoria, Sudharshan Hariharan, Durga Paturi, Dhananjay Pal & Ashim K. Mitra. (2006) Biotin Uptake by Rabbit Corneal Epithelial Cells: Role of Sodium-Dependent Multivitamin Transporter (SMVT). Current Eye Research 31:10, pages 797-809.
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Articles from other publishers (33)

Bisera Jurišić Dukovski, Marina Juretić, Stephan Reichl, Ivan Pepić & Jasmina Lovrić. 2024. Concepts and Models for Drug Permeability Studies. Concepts and Models for Drug Permeability Studies 187 218 .
Van Nguyen Tran, Ondřej Strnad, Jáchym Šuman, Tereza Veverková, Adéla Sukupová, Pavel Cejnar, Radovan Hynek, Olga Kronusová, Josef Šach, Petr Kaštánek, Tomáš Ruml & Jitka Viktorová. (2023) Cannabidiol nanoemulsion for eye treatment – Anti-inflammatory, wound healing activity and its bioavailability using in vitro human corneal substitute. International Journal of Pharmaceutics 643, pages 123202.
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Inès De Hoon, Rabah Boukherroub, Stefaan C. De Smedt, Sabine Szunerits & Félix Sauvage. (2023) In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea . Molecular Pharmaceutics 20:7, pages 3298-3319.
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Krystyna Lieto, Rafał Skopek, Aneta Lewicka, Marta Stelmasiak, Emilia Klimaszewska, Arthur Zelent, Łukasz Szymański & Sławomir Lewicki. (2022) Looking into the Eyes—In Vitro Models for Ocular Research. International Journal of Molecular Sciences 23:16, pages 9158.
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Manuel Chacón, Natalia Vázquez, Silvia Berisa, Mairobi Persinal, Manuel Sánchez, Begoña Baamonde, Jose F. Alfonso, Luis Fernández-Vega Cueto, Jesús Merayo-Lloves & Álvaro Meana. (2019) QobuR – A new in vitro human corneal epithelial model for preclinical drug screening. European Journal of Pharmaceutics and Biopharmaceutics 136, pages 164-173.
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Nicole Beißner, Antonio Bolea Albero, Jendrik Füller, Thomas Kellner, Lothar Lauterboeck, Jinghu Liang, Markus Böl, Birgit Glasmacher, Christel C. Müller-Goymann & Stephan Reichl. (2018) Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs. European Journal of Pharmaceutics and Biopharmaceutics 126, pages 57-66.
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Zachary Estlack, Devasier Bennet, Ted Reid & Jungkyu Kim. (2017) Microengineered biomimetic ocular models for ophthalmological drug development. Lab on a Chip 17:9, pages 1539-1551.
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Seppo Rönkkö, Kati-Sisko Vellonen, Kristiina Järvinen, Elisa Toropainen & Arto Urtti. (2016) Human corneal cell culture models for drug toxicity studies. Drug Delivery and Translational Research 6:6, pages 660-675.
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Sara ShafaieVictoria HutterMichael T. CookMarc B. BrownDavid Y.S. Chau. (2016) In Vitro Cell Models for Ophthalmic Drug Development Applications . BioResearch Open Access 5:1, pages 94-108.
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Ruhi V. Ubale & Richard T. Addo. 2016. Ocular Drug Delivery: Advances, Challenges and Applications. Ocular Drug Delivery: Advances, Challenges and Applications 101 115 .
Kouichi Kawazu, Shinobu Fujii, Kazuhito Yamada, Katsuhiko Shinomiya, Osamu Katsuta & Yoshihide Horibe. (2013) Characterization of monocarboxylate uptake and immunohistochemical demonstration of monocarboxylate transporters in cultured rabbit corneal epithelial cells. Journal of Pharmacy and Pharmacology 65:3, pages 328-336.
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Jessica Verstraelen & Stephan Reichl. (2013) Expression analysis of MDR1, BCRP and MRP3 transporter proteins in different in vitro and ex vivo cornea models for drug absorption studies. International Journal of Pharmaceutics 441:1-2, pages 765-775.
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Shinobu Fujii, Hideki Hayashi, Kunihiko Itoh, Shizuo Yamada, Yoshiharu Deguchi & Kouichi Kawazu. (2013) Characterization of the carrier-mediated transport of ketoprofen, a nonsteroidal anti-inflammatory drug, in rabbit corneal epithelium cells. Journal of Pharmacy and Pharmacology 65:2, pages 171-180.
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Matthias Hahne, Michaela Zorn-Kruppa, Gustavo Guzman, Johanna M. Brandner, Eleonore Haltner-Ukomado, Hermann Wätzig & Stephan Reichl. (2012) Prevalidation of a Human Cornea Construct as an Alternative to Animal Corneas for In Vitro Drug Absorption Studies. Journal of Pharmaceutical Sciences 101:8, pages 2976-2988.
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Matthias Hahne & Stephan Reichl. (2011) Development of a serum-free human cornea construct for in vitro drug absorption studies: The influence of varying cultivation parameters on barrier characteristics. International Journal of Pharmaceutics 416:1, pages 268-279.
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Stephan Reichl. (2008) Cell culture models of the human cornea — a comparative evaluation of their usefulness to determine ocular drug absorption in-vitro. Journal of Pharmacy and Pharmacology 60:3, pages 299-307.
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Kouichi Kawazu, Yukari Midori & Atsutoshi Ota. (1999) Cultured Rabbit Corneal Epithelium Elicits Levofloxacin Absorption and Secretion. Journal of Pharmacy and Pharmacology 51:7, pages 791-796.
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Cathie D. Xiang, Minerva Batugo, David C. Gale, Tao Zhang, Jingjing Ye, Chunze Li, Sue Zhou, Ellen Y. Wu & Eric Y. Zhang. (2009) Characterization of Human Corneal Epithelial Cell Model As a Surrogate for Corneal Permeability Assessment: Metabolism and Transport. Drug Metabolism and Disposition 37:5, pages 992-998.
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Yoshihisa Shirasaki. (2008) Molecular Design for Enhancement of Ocular Penetration. Journal of Pharmaceutical Sciences 97:7, pages 2462-2496.
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Noriaki Nagai, Mitsushi Inomata & Yoshimasa Ito. (2008) Contribution of Aldehyde Dehydrogenase 3A1 to Disulfiram Penetration through Monolayers Consisting of Cultured Human Corneal Epithelial Cells. Biological and Pharmaceutical Bulletin 31:7, pages 1444-1448.
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Susan E Northfield & David T Manallack. (2007) Lipophilicity of Beta‐Adrenocepter Antagonists: A New Classification Scheme for Clinical Use. Journal of Pharmacy Practice and Research 37:2, pages 98-101.
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Aphrodite Dracopoulos, D George Dixon, Lyndon W. Jones, Jacob G. Sivak & Vladimir Bantseev. (2007) In Vitro Assessment of Medical Device Toxicity: Interactions of Benzalkonium Chloride With Silicone-Containing and p-HEMA–Containing Hydrogel Contact Lens Materials. Eye & Contact Lens: Science & Clinical Practice 33:1, pages 26-37.
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Kouichi KawazuAkemi Oshita, Tadahiro Nakamura, Mikiro Nakashima, Nobuhiro Ichikawa & Hitoshi Sasaki. (2006) Transport of Acebutolol through Rabbit Corneal Epithelium. Biological and Pharmaceutical Bulletin 29:4, pages 846-849.
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Koji Sakanaka, Kouichi Kawazu, Koyo Nishida, Junzo Nakamura, Mikiro Nakashima, Tadahiro Nakamura, Akemi Oshita, Nobuhiro Ichikawa & Hitoshi Sasaki. (2006) Transport of Timolol and Tilisolol in Rabbit Corneal Epithelium. Biological and Pharmaceutical Bulletin 29:10, pages 2143-2147.
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L. Meyer, J. Bednarz, C. C. Müller-Goymann & S. Reichl. (2005) Esteraseaktivität eines organotypischen humanen Kornea-Konstrukts (HCC) als In-vitro-Modell für PermeationsuntersuchungenEsterase activity of human organotypic cornea construct (HCC) as in vitro model for permeation studies. Der Ophthalmologe 102:10, pages 971-980.
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Margit Hornof, Elisa Toropainen & Arto Urtti. (2005) Cell culture models of the ocular barriers. European Journal of Pharmaceutics and Biopharmaceutics 60:2, pages 207-225.
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Stephan Reichl, Stefanie Döhring, Jürgen Bednarz & Christel C. Müller-Goymann. (2005) Human cornea construct HCC—an alternative for in vitro permeation studies? A comparison with human donor corneas. European Journal of Pharmaceutics and Biopharmaceutics 60:2, pages 305-308.
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Susi BurgalassiDaniela MontiAnnalisa BrignoccoliOrtenzio FabianiCarla LenziAndrea PironePatrizia Chetoni. (2004) Development of Cultured Rabbit Corneal Epithelium for Drug Permeation Studies: A Comparison with Excised Rabbit Cornea. Journal of Ocular Pharmacology and Therapeutics 20:6, pages 518-532.
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Elisa Toropainen, Veli-Pekka Ranta, Kati-Sisko Vellonen, Joni Palmgrén, Anu Talvitie, Mirka Laavola, Pekka Suhonen, Kaisa Mari Hämäläinen, Seppo Auriola & Arto Urtti. (2003) Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. European Journal of Pharmaceutical Sciences 20:1, pages 99-106.
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Stephan Reichl & Christel C Müller-Goymann. (2003) The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride. International Journal of Pharmaceutics 250:1, pages 191-201.
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Vincent Lee, Jennifer Sporty, Arto Urtti & Pekka Suhonen. 2002. Cell Culture Models of Biological Barriers. Cell Culture Models of Biological Barriers 253 270 .
Kenji Kashiwagi, Katsuya Saito, You-Dong Wang, Hiroshi Takahashi, Kiyotaka Ishijima & Shigeo Tsukahara. (2001) Safety of Ozonated Solution as an Antiseptic of the Ocular Surface prior to Ophthalmic Surgery. Ophthalmologica 215:5, pages 351-356.
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You-Dong Wang, Kenji Kashiwagi, Hai-Bo Chen, Ming Jin, Bo Ou, Yoko Iizuka, Yuko Tanaka & Shigeo Tsukahara. (2001) Effects of Isopropyl Unoprostone Ophthalmic Solution on Cultured Rabbit Corneal Epithelial Cells. Ophthalmologica 215:3, pages 229-234.
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