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Current Eye Research Volume 18, 1999 - Issue 3
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Research Article

Role of P-glycoprotein in distribution of rhodamine 123 into aqueous humor in rabbits

Tetsu Kajikawa Department of Ophthalmology and Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
,
Hiromu Mishima Department of Ophthalmology and Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
,
Hiromu Mishima Department of Ophthalmology and Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
,
Teruo Murakami Department of Ophthalmology and Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
&
Mikihisa Takano Department of Ophthalmology and Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
Pages 240-246 | Published online: 02 Jul 2009

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Srinivasan Senthilkumari, Thirumurthy Velpandian, Nihar Ranjan Biswas, Rohit Saxena & Supriyo Ghose. (2008) Evaluation of the Modulation of P-glycoprotein (P-gp) on the Intraocular Disposition of its Substrate in Rabbits. Current Eye Research 33:4, pages 333-343.
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Sridhar Duvvuri, Mohit D. Gandhi & Ashim K. Mitra. (2003) Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine. Current Eye Research 27:6, pages 345-353.
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Clapton Dias, Yasser Nashed, Harisha Atluri & Ashim Mitra. (2002) Ocular penetration of acyclovir and its peptide prodrugs valacyclovir and val-valacyclovir following systemic administration in rabbits: An evaluation using ocular microdialysis and LC-MS. Current Eye Research 25:4, pages 243-252.
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Christina U. Johnston & Christopher J. Kennedy. (2024) A Review of P-Glycoprotein Function and Regulation in Fish. Fishes 9:2, pages 51.
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Mahmoud Mostafa, Adel Al Fatease, Raid G. Alany & Hamdy Abdelkader. (2023) Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases. Pharmaceutics 15:6, pages 1746.
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Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Surya P. Lamichhane, Bharathi Avula, XiangDi Wang, Monica M. Jablonski, Ikhlas A. Khan & Soumyajit Majumdar. (2018) Retina Compatible Interactions and Effective Modulation of Blood Ocular Barrier P-gp Activity by Third-Generation Inhibitors Improve the Ocular Penetration of Loperamide. Journal of Pharmaceutical Sciences 107:8, pages 2128-2135.
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Akshaya Tatke, Karthik Yadav Janga, Bharathi Avula, XiangDi Wang, Monica M. Jablonski, Ikhlas A. Khan & Soumyajit Majumdar. (2018) P-glycoprotein Restricts Ocular Penetration of Loperamide across the Blood-Ocular Barriers: a Comparative Study in Mdr1a Knock-out and Wild Type Sprague Dawley Rats. AAPS PharmSciTech 19:4, pages 1662-1671.
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Kati-Sisko Vellonen, Laura Hellinen, Eliisa Mannermaa, Marika Ruponen, Arto Urtti & Heidi Kidron. (2018) Expression, activity and pharmacokinetic impact of ocular transporters. Advanced Drug Delivery Reviews 126, pages 3-22.
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Peng Chen, Hao Chen, Xinjie Zang, Min Chen, Haoran Jiang, Shasha Han & Xianggen Wu. (2013) Expression of Efflux Transporters in Human Ocular Tissues. Drug Metabolism and Disposition 41:11, pages 1934-1948.
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Roland J. Bainton & Evan D. Kharasch. 2011. Anesthetic Pharmacology. Anesthetic Pharmacology 90 102 .
Eliisa Mannermaa, Mika Reinisalo, Veli-Pekka Ranta, Kati-Sisko Vellonen, Heidi Kokki, Anni Saarikko, Kai Kaarniranta & Arto Urtti. (2010) Filter-cultured ARPE-19 cells as outer blood–retinal barrier model. European Journal of Pharmaceutical Sciences 40:4, pages 289-296.
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Zhao-Hui Huang, Teruo Murakami, Atsuko Okochi, Ryoko Yumoyo, Junya Nagai & Mikihisa Takano. (2001) Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure. Journal of Pharmacy and Pharmacology 53:6, pages 873-881.
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Yuka Ishikawa, Junya Nagai, Yumi Okada, Koya Sato, Ryoko Yumoto & Mikihisa Takano. (2010) Function and Expression of ATP-Binding Cassette Transporters in Cultured Human Y79 Retinoblastoma Cells. Biological and Pharmaceutical Bulletin 33:3, pages 504-511.
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Srinivasan SenthilkumariThirumurthy VelpandianNihar R. BiswasNarayanan SonaliSupriyo Ghose. (2008) Evaluation of the Impact of P-Glycoprotein (P-gp) Drug Efflux Transporter Blockade on the Systemic and Ocular Disposition of P-gp Substrate. Journal of Ocular Pharmacology and Therapeutics 24:3, pages 290-300.
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Narumi Sugihara, Kumiko Toyama, Akihiro Michihara, Kenji Akasaki, Hiroshi Tsuji & Koji Furuno. (2006) Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer. Toxicology 223:1-2, pages 156-165.
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Gangadhar Sunkara & Uday Kompella. 2003. Ophthalmic Drug Delivery Systems, Second Edition. Ophthalmic Drug Delivery Systems, Second Edition 13 58 .
Zhao-Hui Huang, Teruo Murakami, Atsuko Okochi, Ryoko Yumoto, Junya Nagai & Mikihisa Takano. (2000) Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. European Journal of Pharmacology 406:3, pages 453-460.
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