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Research Article

Human ß-defensin 2 is up-regulated during re-epithelialization of the cornea

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Pages 64-67 | Published online: 02 Jul 2009

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Xiaoyong Yuan, Xia Hua & Kirk R. Wilhelmus. (2010) The Corneal Expression of Antimicrobial Peptides during Experimental Fungal Keratitis. Current Eye Research 35:10, pages 872-879.
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Ling C. Huang, Daniele Jean, Rita J. Proske, Rose Y. Reins & Alison M. McDermott. (2007) Ocular Surface Expression and In Vitro Activity of Antimicrobial Peptides. Current Eye Research 32:7-8, pages 595-609.
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Articles from other publishers (36)

Darren Shu Jeng Ting, Imran Mohammed, Rajamani Lakshminarayanan, Roger W. Beuerman & Harminder S. Dua. (2022) Host Defense Peptides at the Ocular Surface: Roles in Health and Major Diseases, and Therapeutic Potentials. Frontiers in Medicine 9.
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Allison H. Shannon, Sara A. Adelman, Erin A. Hisey, Sanskruti S. Potnis, Vanessa Rozo, Madeline W. Yung, Jennifer Y. Li, Christopher J. Murphy, Sara M. Thomasy & Brian C. Leonard. (2022) Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis. Frontiers in Microbiology 13.
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Praveen Kumar Jadi, Prerana Sharma, Bharathi Bhogapurapu & Sanhita Roy. (2021) Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis. Frontiers in Chemistry 9.
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Richard O’Callaghan. (2018) The Pathogenesis of Staphylococcus aureus Eye Infections. Pathogens 7:1, pages 9.
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Rachel L. Redfern, Stefano Barabino, Jessica Baxter, Carolina Lema & Alison M. McDermott. (2015) Dry eye modulates the expression of toll-like receptors on the ocular surface. Experimental Eye Research 134, pages 80-89.
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Satya Sree N. Kolar, Vincenzo Luca, Hasna Baidouri, Giuseppe Mannino, Alison M. McDermott & Maria Luisa Mangoni. (2014) Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis. Cellular and Molecular Life Sciences 72:3, pages 617-627.
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Sumeyya AkyolVeli UgurcuMehmet BalciAyse GurelGonul ErdenOzlem CakmakOmer Akyol. (2014) Caffeic Acid Phenethyl Ester: Its Protective Role Against Certain Major Eye Diseases. Journal of Ocular Pharmacology and Therapeutics 30:9, pages 700-708.
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Adone Baroni, Elisabetta Buommino, Vincenzo Piccolo, Marco Adriano Chessa, Teresa Russo, Valentina Cozza & Vincenzo Ruocco. (2014) Alterations of skin innate immunity in lymphedematous limbs: Correlations with opportunistic diseases. Clinics in Dermatology 32:5, pages 592-598.
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Jeong-Im Woo, Sung-Hee Kil, Huiqi Pan, Yoo Jin Lee, David J. Lim & Sung K. Moon. (2014) Distal NF-kB binding motif functions as an enhancer for nontypeable H. influenzae-induced DEFB4 regulation in epithelial cells. Biochemical and Biophysical Research Communications 443:3, pages 1035-1040.
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Srihari Narayanan, Rachel L. Redfern, William L. Miller, Kelly K. Nichols & Alison M. McDermott. (2013) Dry Eye Disease and Microbial Keratitis: Is There a Connection?. The Ocular Surface 11:2, pages 75-92.
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Mona Ståhle. 2013. Antimicrobial Peptides and Innate Immunity. Antimicrobial Peptides and Innate Immunity 123 139 .
Kristin Jäger, Andrea Nielitz, Fabian Garreis, Saadettin Sel, Heike Nave & Friedrich P. Paulsen. (2011) In vitro evidence of involvement of the epithelial y+ transporter in β-defensin production on the ocular surface. Annals of Anatomy - Anatomischer Anzeiger 193:6, pages 479-485.
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Imran Mohammed, Asiya Abedin, Kostas Tsintzas, Syed A Abedin, Ahmad M Otri, Andrew Hopkinson, Manu Mathew & Harminder S Dua. (2011) Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis. Cornea 30:8, pages 899-904.
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Satya S. Kolar & Alison M. McDermott. (2011) Role of host-defence peptides in eye diseases. Cellular and Molecular Life Sciences 68:13, pages 2201-2213.
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Rachel L. Redfern, Rose Y. Reins & Alison M. McDermott. (2011) Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells. Experimental Eye Research 92:3, pages 209-220.
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Carol L. Bratt, Phil Wertz, David Drake, Deborah V. Dawson & Kim A. Brogden. 2011. Lipids and Essential Oils as Antimicrobial Agents. Lipids and Essential Oils as Antimicrobial Agents 99 121 .
Fabian Garreis, Thomas Schlorf, Dieter Worlitzsch, Philipp Steven, Lars Bräuer, Kristin Jäger & Friedrich P. Paulsen. (2010) Roles of human β-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells. Histochemistry and Cell Biology 134:1, pages 59-73.
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Alison McDermott. 2009. Bioactive Peptides. Bioactive Peptides 357 401 .
J. M. Meredith, H. Hurd, M. J. Lehane & P. Eggleston. (2008) The malaria vector mosquito Anopheles gambiae expresses a suite of larval‐specific defensin genes . Insect Molecular Biology 17:2, pages 103-112.
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Ling C. Huang, Rachel L. Redfern, Srihari Narayanan, Rose Y. Reins & Alison M. McDermott. (2007) In Vitro Activity of Human β-Defensin 2 against Pseudomonas aeruginosa in the Presence of Tear Fluid . Antimicrobial Agents and Chemotherapy 51:11, pages 3853-3860.
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I.A. Maltseva, S.M.J. Fleiszig, D.J. Evans, S. Kerr, S.S. Sidhu, N.A. McNamara & C. Basbaum. (2007) Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human β-defensin-2 in response to antigens of Pseudomonas aeruginosa. Experimental Eye Research 85:1, pages 142-153.
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David J. Evans, Nancy A. McNamara & Suzanne M.J. Fleiszig. (2007) Life at the Front: Dissecting Bacterial-Host Interactions at the Ocular Surface. The Ocular Surface 5:3, pages 213-227.
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Srihari Narayanan, Jennifer Manning, Rita Proske & Alison M McDermott. (2006) Effect of Hyperosmolality on β-Defensin Gene Expression by Human Corneal Epithelial Cells. Cornea 25:9, pages 1063-1068.
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Ai Ikeda, Yoko Nakanishi, Tohru Sakimoto, Jun Shoji, Mitsuru Sawa & Norimichi Nemoto. (2006) Expression of β Defensins in Ocular Surface Tissue of Experimentally Developed Allergic Conjunctivitis Mouse Model. Japanese Journal of Ophthalmology 50:1, pages 1-6.
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Ashok Kumar, Jing Zhang & Fu-Shin X. Yu. (2006) Toll-like receptor 2-mediated expression of β-defensin-2 in human corneal epithelial cells. Microbes and Infection 8:2, pages 380-389.
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David Proud. (2006) The role of defensins in virus-induced asthma. Current Allergy and Asthma Reports 6:1, pages 81-85.
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Deike Varoga, Thomas Pufe, Rolf Mentlein, Susanne Kohrs, Susanne Grohmann, Bernhard Tillmann, Joachim Hassenpflug & Friedrich Paulsen. (2005) Expression and regulation of antimicrobial peptides in articular joints. Annals of Anatomy - Anatomischer Anzeiger 187:5-6, pages 499-508.
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David K. Meyerholz & Mark R. Ackermann. (2005) Antimicrobial peptides and surfactant proteins in ruminant respiratory tract disease. Veterinary Immunology and Immunopathology 108:1-2, pages 91-96.
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Karsten Gronert. (2005) Lipoxins in the eye and their role in wound healing. Prostaglandins, Leukotrienes and Essential Fatty Acids 73:3-4, pages 221-229.
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Ling C. Huang, Daniele Jean & Alison M. McDermott. (2005) Effect of Preservative-Free Artificial Tears on the Antimicrobial Activity of Human ??-Defensin-2 and Cathelicidin LL-37 In Vitro. Eye & Contact Lens: Science & Clinical Practice 31:1, pages 34-38.
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Stephen M. Milner, Satyanarayan Bhat, Maximilian Buja, Salil Gulati, Brian J. Poindexter & Roger J. Bick. (2004) Expression of human β defensin 2 in thermal injury. Burns 30:7, pages 649-654.
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Alison M. McDermott. (2004) Defensins and Other Antimicrobial Peptides at the Ocular Surface. The Ocular Surface 2:4, pages 229-247.
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Kazuto Terai, Yoichiro Sano, Satoshi Kawasaki, Ken-ichi Endo, Wakako Adachi, Takeaki Hiratsuka, Hirotoshi Ihiboshi, Masamitsu Nakazato & Shigeru Kinoshita. (2004) Effects of dexamethasone and cyclosporin A on human β-defensin in corneal epithelial cells. Experimental Eye Research 79:2, pages 175-180.
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L. Zhou, L. Q. Huang, R. W. Beuerman, M. E. Grigg, S. F. Y. Li, F. T. Chew, L. Ang, M. E. Stern & D. Tan. (2004) Proteomic Analysis of Human Tears:  Defensin Expression after Ocular Surface Surgery. Journal of Proteome Research 3:3, pages 410-416.
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Diana C. Fleming, Anne E. King, Alistair R.W. Williams, Hilary O.D. Critchley & Rodney W. Kelly. (2003) Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium. Fertility and Sterility 79:4, pages 856-863.
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P.S Hiemstra. (2001) Epithelial antimicrobial peptides and proteins: their role in host defence and inflammation. Paediatric Respiratory Reviews 2:4, pages 306-310.
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