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Current Eye Research Volume 28, 2004 - Issue 2
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Research Article

Ocular disposition of novel lipophilic diester prodrugs of ganciclovir following intravitreal administration using microdialysis

Sreeraj Macha Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Missouri, USA
,
Sridhar Duvvuri Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Missouri, USA
&
Ashim K. Mitra Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Missouri, USA
Pages 77-84 | Published online: 02 Jul 2009

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Xiaoyan Yang, Ye Sheng, Animikh Ray, Sujay J. Shah, Hoang M. Trinh, Dhananjay Pal & Ashim K. Mitra. (2016) Uptake and bioconversion of stereoisomeric dipeptide prodrugs of ganciclovir by nanoparticulate carriers in corneal epithelial cells. Drug Delivery 23:7, pages 2532-2540.
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Articles from other publishers (16)

Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski & Seppo Auriola. (2023) Mass spectrometry in ocular drug research. Mass Spectrometry Reviews.
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Anam Hammid, John K. Fallon, Toni Lassila, Paula Vieiro, Anusha Balla, Francisco Gonzalez, Arto Urtti, Philip C. Smith, Ari Tolonen & Paavo Honkakoski. (2022) Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues. Drug Metabolism and Disposition 50:12, pages 1483-1492.
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Maximilian Hammer, Sonja K. Schickhardt, Patrick R. Merz, Ramin Khoramnia, Alexander F. Scheuerle, Walter Mier, Philipp Uhl & Gerd U. Auffarth. (2022) Intravitreal Application: Physicochemical Properties of Drugs Dissolved in Silicone Oils of Different Density in Comparison to the Porcine Vitreous Body. Pharmaceutics 14:7, pages 1364.
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Muhammad Faris Adrianto, Febri Annuryanti, Clive G. Wilson, Ravi Sheshala & Raghu Raj Singh Thakur. (2021) In vitro dissolution testing models of ocular implants for posterior segment drug delivery. Drug Delivery and Translational Research 12:6, pages 1355-1375.
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Mohammad Mofidfar, Behnam Abdi, Samad Ahadian, Ebrahim Mostafavi, Tejal A. Desai, Farhang Abbasi, Yang Sun, Edward E. Manche, Christopher N. Ta & Charles W. Flowers. (2021) Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies. International Journal of Pharmaceutics 607, pages 120924.
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Jagpreet kour, Neha Kumari & Bharti Sapra. (2021) Ocular prodrugs: Attributes and challenges. Asian Journal of Pharmaceutical Sciences 16:2, pages 175-191.
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Emma M. Heikkinen, Eva M. del Amo, Veli-Pekka Ranta, Arto Urtti, Kati-Sisko Vellonen & Marika Ruponen. (2018) Esterase activity in porcine and albino rabbit ocular tissues. European Journal of Pharmaceutical Sciences 123, pages 106-110.
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Mitesh R. Patel, Nanda K. Mandava & Ashim K. Mitra. 2013. Microdialysis in Drug Development. Microdialysis in Drug Development 197 222 .
Heidi Kidron, Eva M. del Amo, Kati-Sisko Vellonen & Arto Urtti. (2012) Prediction of the Vitreal Half-Life of Small Molecular Drug-Like Compounds. Pharmaceutical Research 29:12, pages 3302-3311.
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Uday B Kompella, Rajendra S Kadam & Vincent HL Lee. (2010) Recent advances in ophthalmic drug delivery. Therapeutic Delivery 1:3, pages 435-456.
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Kumar G. JanoriaSai H.S. BodduSubramanian NatesanAshim K. Mitra. (2010) Vitreal Pharmacokinetics of Peptide-Transporter-Targeted Prodrugs of Ganciclovir in Conscious Animals. Journal of Ocular Pharmacology and Therapeutics 26:3, pages 265-271.
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Sai HS BodduSriram GundaRavinder EarlaAshim K Mitra. (2010) Ocular microdialysis: a continuous sampling technique to study pharmacokinetics and pharmacodynamics in the eye. Bioanalysis 2:3, pages 487-507.
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Thomas Wai-Yip LeeJoseph R. Robinson. (2009) Drug Delivery to the Posterior Segment of the Eye IV: Theoretical Formulation of a Drug Delivery System for Subconjunctival Injection. Journal of Ocular Pharmacology and Therapeutics 25:1, pages 29-38.
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Sridhar DuvvuriKumar G. JanoriaDhananjay PalAshim K. Mitra. (2007) Controlled Delivery of Ganciclovir to the Retina with Drug-Loaded Poly(D,L-lactide-co-glycolide) (PLGA) Microspheres Dispersed in PLGA-PEG-PLGA Gel: A Novel Intravitreal Delivery System for the Treatment of Cytomegalovirus Retinitis. Journal of Ocular Pharmacology and Therapeutics 23:3, pages 264-274.
Crossref
Soumyajit MajumdarViral KansaraAshim K. Mitra. (2006) Vitreal Pharmacokinetics of Dipeptide Monoester Prodrugs of Ganciclovir. Journal of Ocular Pharmacology and Therapeutics 22:4, pages 231-241.
Crossref
Nele Plock & Charlotte Kloft. (2005) Microdialysis—theoretical background and recent implementation in applied life-sciences. European Journal of Pharmaceutical Sciences 25:1, pages 1-24.
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