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Original Papers

Reduction of Blood Loss with Tranexamic Acid in Primary Total Hip Replacement Surgery

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Pages 397-401 | Published online: 11 Mar 2016

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Jamie S McConnell, Sandeep Shewale, Niall A Munro, Kalpesh Shah, Angela H Deakin & Andrew WG Kinninmonth. (2011) Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. Acta Orthopaedica 82:6, pages 660-663.
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Articles from other publishers (96)

Victoria N Gibbs, Rita Champaneria, Josie Sandercock, Nicky J Welton, Louise J Geneen, Susan J Brunskill, Carolyn Dorée, Catherine Kimber, Antony JR Palmer & Lise J Estcourt. (2024) Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2024:1.
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Carsten Perka, Christian von Heymann, Heiko Lier, Lutz Kaufner & Sascha Treskatsch. (2023) The Perioperative Application of Tranexamic Acid. Zeitschrift für Orthopädie und Unfallchirurgie 161:05, pages 532-537.
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Che Zheng, Jun Ma, Jiawen Xu, Liming Wu, Yuangang Wu, Yuan Liu & Bin Shen. (2023) The optimal regimen, efficacy and safety of tranexamic acid and aminocaproic acid to reduce bleeding for patients after total hip arthroplasty: A systematic review and Bayesian network meta-analysis. Thrombosis Research 221, pages 120-129.
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Aziz Çataltepe & Kadir Öznam. (2022) The Effects of Press-Fit Technique Combined with Tranexamic Acid on Duration of Surgery and Intraoperative Blood Loss in Primary Total Hip Arthroplasty. Cureus.
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AhmedR Khamis, SaadA Shoulah & DinaH Abdelhamid. (2022) Combined administration of tranexamic acid and vitamin K proved perioperative blood loss reduction with cementless total hip replacement: a prospective randomized controlled study. The Egyptian Orthopaedic Journal 57:2, pages 138.
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Olaoluwa Moses Shodipo, Hamzah Ibrahim Jatto, Ali Mohammed Ramat, Shaphat Shuaibu Ibrahim, Lukman Olalekan Ajiboye, Soluideen Adebayo Arojuraye, John Adeniran James & Adetunji Mapaderun Toluse. (2021) Comparison of single versus double tranexamic acid dose regimens in reducing post-operative blood loss following intramedullary nailing of femoral fracture nonunions. International Orthopaedics 46:1, pages 97-101.
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Hakan Avci. (2021) The Effect of Different Dose Regimens of Tranexamic Acid in Reducing Blood Loss in Rhinoplasty: A Prospective Randomized Controlled Study. Journal of Craniofacial Surgery 32:5, pages e442-e444.
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Isabel Taeuber, Stephanie Weibel, Eva Herrmann, Vanessa Neef, Tobias Schlesinger, Peter Kranke, Leila Messroghli, Kai Zacharowski, Suma Choorapoikayil & Patrick Meybohm. (2021) Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality. JAMA Surgery 156:6, pages e210884.
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Davide Reale, Luca Andriolo, Safa Gursoy, Murat Bozkurt, Giuseppe Filardo & Stefano Zaffagnini. (2021) Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International 2021, pages 1-14.
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祥 姬. (2021) Effect of Drugs on Hidden Blood Loss after Total Hip Arthroplasty. Advances in Clinical Medicine 11:02, pages 553-558.
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Yi-Ting Lei, Jin-Wei Xie, Qiang Huang, Wei Huang & Fu-Xing Pei. (2019) The antifibrinolytic and anti-inflammatory effects of a high initial-dose tranexamic acid in total knee arthroplasty: a randomized controlled trial. International Orthopaedics 44:3, pages 477-486.
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Qiu‐ru Wang, Releken Yeersheng, Dong‐hai Li, Zhou‐yuan Yang & Peng‐de Kang. (2019) Intravenous Tranexamic Acid for Reducing Perioperative Blood Loss During Revision Surgery for Vancouver Type B Periprosthetic Femoral Fractures After Total Hip Arthroplasty: A Retrospective Study. Orthopaedic Surgery 12:1, pages 100-107.
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Mohamed Sukeik, Sattar Alshryda, James Powell & Fares S. Haddad. (2020) The effect of tranexamic acid on wound complications in primary total Hip Arthroplasty: A meta-analysis. The Surgeon 18:1, pages 53-61.
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Michal Balík, Josef Košina, Petr Hušek, Miloš Broďák & Filip Čečka. (2020) Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study. Acta Medica (Hradec Kralove, Czech Republic) 63:4, pages 176-182.
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Javahir A. Pachore, Vikram Indrajit Shah, Sachin Upadhyay, Kalpesh Shah, Ashish Sheth & Amish Kshatriya. (2019) The use of tranexamic acid to reduce blood loss in uncemented total hip arthroplasty for avascular necrosis of femoral head: a prospective blinded randomized controlled study. Arthroplasty 1:1.
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Zhihu Zhao, Jianxiong Ma & Xinlong Ma. (2019) Comparative efficacy and safety of different hemostatic methods in total hip arthroplasty: a network meta-analysis. Journal of Orthopaedic Surgery and Research 14:1.
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James H. Derzon, Nicole Clarke, Aaron Alford, Irwin Gross, Aryeh Shander & Robert Thurer. (2019) Reducing red blood cell transfusion in orthopedic and cardiac surgeries with Antifibrinolytics: A laboratory medicine best practice systematic review and meta-analysis. Clinical Biochemistry 71, pages 1-13.
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Sandeep Kashyap, Shweta Mahajan & Mukand Lal. (2019) Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. Acta Orthopaedica et Traumatologica Turcica 53:3, pages 175-179.
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Michal Balík & Jaroslav Pacovský. (2019) Pharmacological prophylaxis of bleeding in urological procedures. Urologie pro praxi 20:1, pages 13-18.
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Vahid Monsef Kasmaei, Amin Javadi & Seyed Ahmad Naseri Alavi. (2019) Effects of tranexamic acid on reducing blood loss in pelvic trauma: A randomised double-blind placebo controlled study. Journal of Clinical Orthopaedics and Trauma 10:2, pages 286-289.
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Jeffrey Yates, Iris Perelman, Simonne Khair, Joshua Taylor, Jacinthe Lampron, Alan Tinmouth & Elianna Saidenberg. (2018) Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta‐analysis. Transfusion 59:2, pages 806-824.
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Byung-Ho Yoon, Tae-young Kim, Young Seung Ko, Young-Kyun Lee, Yong-Chan Ha & Kyung-Hoi Koo. (2018) Optimal use of tranexamic acid for total hip arthroplasty: A network meta-analysis. PLOS ONE 13:10, pages e0206480.
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Yale A. Fillingham, Dipak B. Ramkumar, David S. Jevsevar, Adolph J. Yates, Peter Shores, Kyle Mullen, Stefano A. Bini, Henry D. Clarke, Emil Schemitsch, Rebecca L. Johnson, Stavros G. Memtsoudis, Siraj A. Sayeed, Alexander P. Sah & Craig J. Della Valle. (2018) The Efficacy of Tranexamic Acid in Total Hip Arthroplasty: A Network Meta-analysis. The Journal of Arthroplasty 33:10, pages 3083-3089.e4.
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Yale A. Fillingham, Dipak B. Ramkumar, David S. Jevsevar, Adolph J. Yates, Peter Shores, Kyle Mullen, Stefano A. Bini, Henry D. Clarke, Emil Schemitsch, Rebecca L. Johnson, Stavros G. Memtsoudis, Siraj A. Sayeed, Alexander P. Sah & Craig J. Della Valle. (2018) The Safety of Tranexamic Acid in Total Joint Arthroplasty: A Direct Meta-Analysis. The Journal of Arthroplasty 33:10, pages 3070-3082.e1.
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Seher Orbay Yaşlı, Zeynep Tosun, Mehmet Halıcı & Selda Kahraman Kayaaltı. (2018) Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study. Journal of Surgery and Medicine.
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Jonathan Peck, David M. Kepecs, Bill Mei, Oleg A. Safir, David Backstein, Allan E. Gross & Paul R. Kuzyk. (2018) The Effect of Preoperative Administration of Intravenous Tranexamic Acid During Revision Hip Arthroplasty. Journal of Bone and Joint Surgery 100:17, pages 1509-1516.
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Dipak B. Ramkumar, Niveditta Ramkumar, Stephanie J. Tapp & Wayne E. Moschetti. (2018) Pharmacologic Hemostatic Agents in Total Joint Arthroplasty—A Cost-Effectiveness Analysis. The Journal of Arthroplasty 33:7, pages 2092-2099.e9.
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Ramakrishna Prasad, Abhiruchi Patki, Shibany Padhy & Gopinath Ramchandran. (2018) Single intravenous bolus versus perioperative continuous infusion of tranexamic acid to reduce blood loss in abdominal oncosurgical procedures: A prospective randomized double-blind clinical study. Journal of Anaesthesiology Clinical Pharmacology 34:4, pages 529.
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Jianxi Zhu, Yong Zhu, Pengfei Lei, Min Zeng, Weiping Su & Yihe Hu. (2017) Efficacy and safety of tranexamic acid in total hip replacement. Medicine 96:52, pages e9552.
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J. XieQ. HuJ. MaQ. HuangF. Pei. (2017) Multiple boluses of intravenous tranexamic acid to reduce hidden blood loss and the inflammatory response following enhanced-recovery primary total hip arthroplasty. The Bone & Joint Journal 99-B:11, pages 1442-1449.
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William D. LackBrett D. CristRachel B. Seymour, William HarvinMadhav A. Karunakar. (2017) Effect of Tranexamic Acid on Transfusion: A Randomized Clinical Trial in Acetabular Fracture Surgery. Journal of Orthopaedic Trauma 31:10, pages 526-530.
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Aatif Mahmood, Seif Sawalha, Aaron Borbora, Gunasekaran Kumar & Viju Peter. (2017) Tranexamic acid versus fibrin sealant in primary total hip replacement: a comparative study. European Journal of Orthopaedic Surgery & Traumatology 27:7, pages 923-928.
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A. Lopez-PicadoA. AlbinarrateBorja Barrachina. (2017) Determination of Perioperative Blood Loss: Accuracy or Approximation?. Anesthesia & Analgesia 125:1, pages 280-286.
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Chad D. Watts, Matthew T. Houdek, S. Andrew Sems, William W. Cross & Mark W. Pagnano. (2017) Tranexamic Acid Safely Reduced Blood Loss in Hemi- and Total Hip Arthroplasty for Acute Femoral Neck Fracture: A Randomized Clinical Trial. Journal of Orthopaedic Trauma 31:7, pages 345-351.
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Yi Zeng, Hai‐Bo Si, Bin Shen, Jing Yang, Zong‐ke Zhou, Peng‐de Kang & Fu‐xing Pei. (2017) Intravenous Combined with Topical Administration of Tranexamic Acid in Primary Total Hip Arthroplasty: A Randomized Controlled Trial. Orthopaedic Surgery 9:2, pages 174-179.
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Nariaki NakuraKazuo HirakawaSatoshi TakayanagiAkira SaitoKoji TsujiYasunobu TamakiShunsuke OchiaiMasahiko Mihara. (2016) Additional intraarticular tranexamic acid further reduced postoperative blood loss compared to intravenous and topical bathed tranexamic acid in total hip arthroplasty: a retrospective sequential series study. Transfusion 57:4, pages 977-984.
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Erdan Kayupov, Yale A. Fillingham, Kamil Okroj, Darren R. Plummer, Mario Moric, Tad L. Gerlinger & Craig J. Della Valle. (2017) Oral and Intravenous Tranexamic Acid Are Equivalent at Reducing Blood Loss Following Total Hip Arthroplasty. Journal of Bone and Joint Surgery 99:5, pages 373-378.
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Young-Hoo Kim, Jang-Won Park & Jun-Shik Kim. (2017) Chemical Thromboprophylaxis Is Not Necessary to Reduce Risk of Thromboembolism With Tranexamic Acid After Total Hip Arthroplasty. The Journal of Arthroplasty 32:2, pages 641-644.
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