7,804
Views
52
CrossRef citations to date
0
Altmetric
Research Article

Pathophysiology of bone pain: A review

Pages 308-317 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Hiroaki Ohta, Etsuro Hamaya, Masanori Taketsuna & Hideaki Sowa. (2015) Quality of life in Japanese women with postmenopausal osteoporosis treated with raloxifene and vitamin D: post hoc analysis of a postmarketing study. Current Medical Research and Opinion 31:1, pages 85-94.
Read now
Kousei Yoh, Etsuro Hamaya, Hisashi Urushihara, Noriko Iikuni, Takanori Yamamoto, Masanori Taketsuna, Akimitsu Miyauchi, Hideaki Sowa & Kiyoshi Tanaka. (2012) Quality of life in raloxifene-treated Japanese women with postmenopausal osteoporosis: a prospective, postmarketing observational study. Current Medical Research and Opinion 28:11, pages 1757-1766.
Read now
Hrachya Nersesyan & Konstantin V Slavin. (2007) Current aproach to cancer pain management: Availability and implications of different treatment options. Therapeutics and Clinical Risk Management 3:3, pages 381-400.
Read now
S. Scharla, H. Oertel, K. Helsberg, F. Kessler, F. Langer & T. Nickelsen. (2006) Skeletal pain in postmenopausal women with osteoporosis: prevalence and course during raloxifene treatment in a prospective observational study of 6 months duration. Current Medical Research and Opinion 22:12, pages 2393-2402.
Read now

Articles from other publishers (48)

W. C. Lee, C. M. B. Foong, K. M. S. Khoo, Y. H. Kwan & R. Kunnasegaran. (2023) Faster improvement in outcome scores in posterior stabilised total knee arthroplasty compared to medial congruent system with posterior cruciate ligament retained. MUSCULOSKELETAL SURGERY.
Crossref
Lucia Iafrate, Maria Cristina Benedetti, Samantha Donsante, Alessandro Rosa, Alessandro Corsi, Richard O. C. Oreffo, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio & Gianluca Cidonio. (2022) Modelling skeletal pain harnessing tissue engineering. In vitro models 1:4-5, pages 289-307.
Crossref
Gehua Zhen, Yuhan Fu, Chi Zhang, Neil C. Ford, Xiaojun Wu, Qichao Wu, Dong Yan, Xueming Chen, Xu Cao & Yun Guan. (2022) Mechanisms of bone pain: Progress in research from bench to bedside. Bone Research 10:1.
Crossref
Ibtesam Rajpar & Ryan E. Tomlinson. (2022) Function of peripheral nerves in the development and healing of tendon and bone. Seminars in Cell & Developmental Biology 123, pages 48-56.
Crossref
Mohsen Akbarian, Ali Khani, Sara Eghbalpour & Vladimir N. Uversky. (2022) Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action. International Journal of Molecular Sciences 23:3, pages 1445.
Crossref
Kester A. Phillips & David Schiff. 2022. Neurological Complications of Systemic Cancer and Antineoplastic Therapy. Neurological Complications of Systemic Cancer and Antineoplastic Therapy 115 131 .
Sara Nencini, Michael Morgan, Jenny Thai, Andrew I. Jobling, Stuart B. Mazzone & Jason J. Ivanusic. (2021) Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons. Frontiers in Physiology 12.
Crossref
Lindsay P. Deloney, Melanie Smith Condeni, Cassandra Carter, Alicia Privette, Stuart Leon & Evert A. Eriksson. (2020) Efficacy of Methocarbamol for Acute Pain Management in Young Adults With Traumatic Rib Fractures. Annals of Pharmacotherapy 55:6, pages 705-710.
Crossref
Víctor Doménech-García, Thorvalur S Palsson, Shellie A Boudreau, Pablo Bellosta-López, Pablo Herrero & Thomas Graven-Nielsen. (2020) Healthy Pain-Free Individuals with a History of Distal Radius Fracture Demonstrate an Expanded Distribution of Experimental Referred Pain Toward the Wrist. Pain Medicine 21:11, pages 2850-2862.
Crossref
Douwe Oostinga, Jasper G. Steverink, Albert J.M. van Wijck & Jorrit-Jan Verlaan. (2020) An understanding of bone pain: A narrative review. Bone 134, pages 115272.
Crossref
Michael Morgan, Jenny Thai, Phu Trinh, Mohamed Habib, Kelly N Effendi & Jason J Ivanusic. (2020) ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Aδ and C fiber sensory neurons that innervate bone. Molecular Pain 16, pages 174480692097595.
Crossref
Ai Mazaki, Sumihisa Orita, Kazuhide Inage, Miyako Suzuki, Kohki Abe, Yasuhiro Shiga, Masahiro Inoue, Masaki Norimoto, Tomotaka Umimura, Seiji Ohtori & Kazuyo Yamauchi. (2019) Tumor Necrosis Factor-α Produced by Osteoclasts Might Induce Intractable Pain in a Rat Spinal Metastasis Model of Breast Cancer. Spine Surgery and Related Research 3:3, pages 261-266.
Crossref
Patrick W. Mantyh. (2018) Mechanisms that drive bone pain across the lifespan. British Journal of Clinical Pharmacology 85:6, pages 1103-1113.
Crossref
Michael Morgan, Sara Nencini, Jenny Thai & Jason J. Ivanusic. (2019) TRPV1 activation alters the function of Aδ and C fiber sensory neurons that innervate bone. Bone 123, pages 168-175.
Crossref
Luc A Sermeus, Luc E Vanlinthout, Guy H Hans, Tom Schepens, Margaretha B Breebaart, Veerle C Verheyen, Carine J Smitz & Marcel P Vercauteren. (2018) Effects of Stellate Ganglion Block on Analgesia Produced by Cervical Paravertebral Block as Established by Quantitative Sensory Testing: A Randomized Controlled Trial. Pain Medicine 19:11, pages 2223-2235.
Crossref
Stephane R. Chartier, Stefanie A.T. Mitchell, Lisa A. Majuta & Patrick W. Mantyh. (2018) The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur. Neuroscience 387, pages 178-190.
Crossref
Domenico Rendina, Gianpaolo De Filippo, Loredana Postiglione, Bianca Covelli, Margherita Ricciardone, Séverine Guillaume, Gaetano Di Spigna, Carmine Selleri, Daniela Merlotti, Simone Bianciardi, Maria Materozzi, Riccardo Muscariello, Francesca De Pascale, Lanfranco D'Elia, Ranuccio Nuti, Pasquale Strazzullo & Luigi Gennari. (2018) Interleukin-6 trans-signaling and pathological low back pain in patients with Paget disease of bone. Pain 159:8, pages 1664-1673.
Crossref
Sara Nencini, Mitchell Ringuet, Dong-Hyun Kim, Claire Greenhill & Jason J. Ivanusic. (2018) GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain. The Journal of Neuroscience 38:21, pages 4899-4911.
Crossref
Daniela Musio, Irene De Francesco, Alessandro Galdieri, Claudia Marsecano, Alfonso Piciocchi, Alessandro Napoli, Francesca De Felice & Vincenzo Tombolini. (2018) Diffusion-weighted magnetic resonance imaging in painful bone metastases: Using quantitative apparent diffusion coefficient as an indicator of effectiveness of single fraction versus multiple fraction radiotherapy. European Journal of Radiology 98, pages 1-6.
Crossref
T. V. Orlyk, N. V. Grygorieva & V. V. Povoroznyuk. (2018) Patterns of Vertebral Pain Syndromes in Women of Older Age Groups Depending on Duration of Postmenopausal Period and Bone Mineral Density Score. Advances in Gerontology 7:4, pages 328-335.
Crossref
Asad E. Patanwala, Ohoud Aljuhani, Brian J. Kopp & Brian L. Erstad. (2017) Methocarbamol use is associated with decreased hospital length of stay in trauma patients with closed rib fractures. The American Journal of Surgery 214:4, pages 738-742.
Crossref
Jason J. Ivanusic. (2017) Molecular Mechanisms That Contribute to Bone Marrow Pain. Frontiers in Neurology 8.
Crossref
Sara Nencini & Jason Ivanusic. (2017) Mechanically sensitive A? nociceptors that innervate bone marrow respond to changes in intra-osseous pressure. The Journal of Physiology 595:13, pages 4399-4415.
Crossref
Sumihisa Orita, Kazuhide Inage, Miyako Suzuki, Kazuki Fujimoto, Kazuyo Yamauchi, Junichi Nakamura, Yusuke Matsuura, Takeo Furuya, Masao Koda, Kazuhisa Takahashi & Seiji Ohtori. (2017) Pathomechanisms and management of osteoporotic pain with no traumatic evidence. Spine Surgery and Related Research 1:3, pages 121-128.
Crossref
Sara Nencini, Mitchell Ringuet, Dong-Hyun Kim, Yu-Jen Chen, Claire Greenhill & Jason J Ivanusic. (2017) Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain. Molecular Pain 13, pages 174480691769701.
Crossref
Sara Nencini & Jason J. Ivanusic. (2016) The Physiology of Bone Pain. How Much Do We Really Know?. Frontiers in Physiology 7.
Crossref
Yannis Dionyssiotis, Georgios Trovas, Sofia Thoma, George Lyritis & Nikolaos Papaioannou. (2015) Prospective study of spinal orthoses in women. Prosthetics & Orthotics International 39:6, pages 487-495.
Crossref
Ali Aghazadeh-Habashi, Yang Yang, Kathy Tang, Raimar Lőbenberg & Michael R. Doschak. (2015) Transdermal drug delivery: feasibility for treatment of superficial bone stress fractures. Drug Delivery and Translational Research 5:6, pages 540-551.
Crossref
Peter Hoskin, Ana Rojas, Elena Fidarova, Rakesh Jalali, Ana Mena Merino, Adela Poitevin, Seam Oucrif, Sherif Abdelwahab, Lotfi Kochbati, Aista Plieskiene, Francesc Casas, Susana Stojanovic, Günther Schneider & Branislav Jeremic. (2015) IAEA randomised trial of optimal single dose radiotherapy in the treatment of painful bone metastases. Radiotherapy and Oncology 116:1, pages 10-14.
Crossref
Stephane R. Chartier, Michelle L. Thompson, Geraldine Longo, Michelle N. Fealk, Lisa A. Majuta & Patrick W. Mantyh. (2014) Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain. Pain 155:11, pages 2323-2336.
Crossref
Jan Puetzler, Robert E. Feldmann Jr.Anne-Kathrin Brascher, Axel Gerhardt & Justus Benrath. (2014) Improvements in Health-Related Quality of Life by Comprehensive Cancer Pain Therapy: A Pilot Study with Breast Cancer Outpatients under Palliative Chemotherapy. Oncology Research and Treatment 37:9, pages 456-462.
Crossref
Marion Desmarchelier, Eric Troncy, Guy Beauchamp, Joanne R. Paul-Murphy, Guy Fitzgerald & Stéphane Lair. (2012) Evaluation of a fracture pain model in domestic pigeons (Columba livia). American Journal of Veterinary Research 73:3, pages 353-360.
Crossref
E. C. RODRIGUEZ‐MERCHAN, V. JIMENEZ‐YUSTE, J. A. AZNAR, U. HEDNER, K. KNOBE, C. A. LEE, R. LJUNG, F. QUEROL, E. SANTAGOSTINO, L. A. VALENTINO & A. CAFFARINI. (2011) Joint protection in haemophilia. Haemophilia 17:s2, pages 1-23.
Crossref
Christopher Lloyd & Mark F. Stidworthy. (2011) Osteofluorosis in Captive Gerenuk (Litocranius walleri) and Bongo (Tragelaphus eurycerus isaaci) Antelope. Journal of Zoo and Wildlife Medicine 42:1, pages 113-117.
Crossref
Jeannette Y. Wick. (2010) Types of Pain: Finding a Drug Regimen That Works. The Consultant Pharmacist 25:6, pages 344-354.
Crossref
Liron Caplan, Cory B. Pittman, Angelique L. Zeringue, Jeffrey F. Scherrer, Kent R. Wehmeier, Francesca E. Cunningham, Seth A. Eisen & Jay R. McDonald. (2010) An Observational Study of Musculoskeletal Pain Among Patients Receiving Bisphosphonate Therapy. Mayo Clinic Proceedings 85:4, pages 341-348.
Crossref
Jason J. Ivanusic, Vineet Sahai & David A. Mahns. (2009) The cortical representation of sensory inputs arising from bone. Brain Research 1269, pages 47-53.
Crossref
Susan E. Bove, Sarah J.L. Flatters, Julia J. Inglis & Patrick W. Mantyh. (2009) New advances in musculoskeletal pain. Brain Research Reviews 60:1, pages 187-201.
Crossref
Jessica A. Cottrell, Markus Meyenhofer, Satyanarayana Medicherla, Linda Higgins & Patrick J. O’Connor. (2009) Analgesic effects of p38 kinase inhibitor treatment on bone fracture healing. Pain 142:1, pages 116-126.
Crossref
Katie T. Freeman, Nathan J. Koewler, Juan M. Jimenez-Andrade, Ryan J. Buus, Monica B. Herrera, Carl D. Martin, Joseph R. Ghilardi, Michael A. Kuskowski & Patrick W. Mantyh. (2008) A Fracture Pain Model in the Rat. Anesthesiology 108:3, pages 473-483.
Crossref
Juan M. Jimenez-Andrade, Carl D. Martin, Nathan J. Koewler, Katie T. Freeman, Lucy J. Sullivan, Kyle G. Halvorson, Christina M. Barthold, Christopher M. Peters, Ryan J. Buus, Joseph R. Ghilardi, Jack L. Lewis, Michael A. Kuskowski & Patrick W. Mantyh. (2007) Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture. Pain 133:1, pages 183-196.
Crossref
Carl D. Martin, Juan Miguel Jimenez-Andrade, Joseph R. Ghilardi & Patrick W. Mantyh. (2007) Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain. Neuroscience Letters 427:3, pages 148-152.
Crossref
Gary C. O’Toole & Patrick Boland. (2006) Metastatic bone cancer pain: Etiology and treatment options. Current Pain and Headache Reports 10:4, pages 288-292.
Crossref
Susan B. LeGrand & Declan Walsh. 2006. Cancer in the Spine. Cancer in the Spine 349 359 .
Birgit Weyand & Herbert P. von Schroeder. (2005) Bone Challenges for the Hand Surgeon: From Basic Bone Biology to Future Clinical Applications. Clinics in Plastic Surgery 32:4, pages 537-547.
Crossref
Piet Geusens, Philip N. Sambrook & Robert LindsayCarlo Gennari & Stefano Gonnelli. 2004. Osteoporosis in Clinical Practice. Osteoporosis in Clinical Practice 87 91 .
Mary Ann C. Sabino, Nancy M. Luger, David B. Mach, Scott D. Rogers, Matthew J. Schwei & Patrick W. Mantyh. (2003) Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer‐related pain behaviors and neurochemical changes in the central nervous system. International Journal of Cancer 104:5, pages 550-558.
Crossref
G M Oades, J Coxon & K W Colston. (2002) The potential role of bisphosphonates in prostate cancer. Prostate Cancer and Prostatic Diseases 5:4, pages 264-272.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.