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Original Article

Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis

A meta-analysis of 6 Nordic cohorts with 73,000 patients

, , &
Pages 351-360 | Received 27 Feb 2002, Published online: 08 Jul 2009

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Read on this site (11)

Michael Kovochich, Brent L. Finley, Rachel Novick, Andrew D. Monnot, Ellen Donovan, Kenneth M. Unice, Ernest S. Fung, David Fung & Dennis J. Paustenbach. (2018) Understanding outcomes and toxicological aspects of second generation metal-on-metal hip implants: a state-of-the-art review. Critical Reviews in Toxicology 48:10, pages 839-887.
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Elina Ekman, Inari Laaksonen, Antti Eskelinen, Pekka Pulkkinen, Eero Pukkala & Keijo Mäkelä. (2018) Midterm risk of cancer with metal-on-metal hip replacements not increased in a Finnish population. Acta Orthopaedica 89:5, pages 575-579.
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Nicole L. Pratt, Flavia M. Cicuttini, Yuanyuan Wang & Stephen E. Graves. (2022) No increased risk of cancer associated with metal-on-metal or ceramic-on-ceramic procedures compared to other bearing surfaces in patients with total hip arthroplasty: A nationwide linked registry cohort analysis of 167,837 patients. PLOS ONE 17:11, pages e0278241.
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Jörg Lützner, Klaus-Peter Günther, Anne Postler & Michael Morlock. (2019) Metal Ion Release after Hip and Knee Arthroplasty – Causes, Biological Effects and Diagnostics. Zeitschrift für Orthopädie und Unfallchirurgie 158:04, pages 369-382.
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Nils P. Hailer, Anne Garland, Max Gordon, Johan Kärrholm, Olof Sköldenberg, Niclas Eriksson, Hans Garmo & Lars Holmberg. (2019) No generally increased risk of cancer after total hip arthroplasty performed due to osteoarthritis. International Journal of Cancer 147:1, pages 76-83.
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Ingrid Milošev. (2017) From In Vitro to Retrieval Studies of Orthopedic Implants. CORROSION 73:12, pages 1496-1509.
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C. L. McCarthy, Y. Uchihara, M. Vlychou, G. Grammatopoulos & N. A. Athanasou. (2017) Development of malignant lymphoma after metal-on-metal hip replacement: a case report and review of the literature. Skeletal Radiology 46:6, pages 831-836.
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Alister J. Hart, Shiraz A. Sabah, Johann Henckel, Gwynneth Lloyd & John A. Skinner. (2018) Lessons Learnt from Metal-On-Metal Hip Arthroplasties will Lead to Safer Innovation for all Medical Devices. HIP International 25:4, pages 347-354.
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C. C. Jørgensen, Ø. Jans & H. Kehlet. (2015) Preoperative anaemia and newly diagnosed cancer 1 year after elective total hip and knee arthroplasty. Vox Sanguinis 109:1, pages 62-70.
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M. Stiehler, F. Zobel, F. Hannemann, J. Schmitt, J. L?tzner, S. Kirschner, K.-P. G?nther & A. Hartmann. (2013) Komplikationen bei Metall-Metall-GleitpaarungenComplications of metal-on-metal tribological pairing. Der Orthop?de 43:1, pages 79-91.
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K.-P. Günther, J. Schmitt, F. Hannemann, J. Lützner, A. Seidler, C. Kopkow, E. Haase, S. Kirschner & A. Hartmann. 2014. Tribology in Total Hip and Knee Arthroplasty. Tribology in Total Hip and Knee Arthroplasty 109 122 .
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Albrecht Hartmann, Franziska Hannemann, Jörg Lützner, Andreas Seidler, Hans Drexler, Klaus-Peter Günther & Jochen Schmitt. (2013) Metal Ion Concentrations in Body Fluids after Implantation of Hip Replacements with Metal-on-Metal Bearing – Systematic Review of Clinical and Epidemiological Studies. PLoS ONE 8:8, pages e70359.
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D H Brewster, D L Stockton, A Reekie, G P Ashcroft, C R Howie, D E Porter & R J Black. (2013) Risk of cancer following primary total hip replacement or primary resurfacing arthroplasty of the hip: a retrospective cohort study in Scotland. British Journal of Cancer 108:9, pages 1883-1890.
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Ioannis Polyzois, Dimitrios Nikolopoulos, Ioannis Michos, Efstratios Patsouris & Stamatios Theocharis. (2012) Local and systemic toxicity of nanoscale debris particles in total hip arthroplasty. Journal of Applied Toxicology 32:4, pages 255-269.
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Brian O'Sullivan, Colleen Dickie, Peter Chung & Charles Catton. 2012. Clinical Radiation Oncology. Clinical Radiation Oncology 1355 1391 .
Paul R. Kim, Paul E. Beaulé, Michael Dunbar, Joshua K.L. Lee, Nicholas Birkett, Michelle C. Turner, Nagarajkumar Yenugadhati, Vic Armstrong & Daniel Krewski. (2011) Cobalt and Chromium Levels in Blood and Urine Following Hip Resurfacing Arthroplasty with the Conserve Plus Implant. Journal of Bone and Joint Surgery 93:Supplement_2, pages 107-117.
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Tuomo Visuri, Håkan Borg, Pekka Pulkkinen, Pekka Paavolainen & Eero Pukkala. (2010) A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up. BMC Musculoskeletal Disorders 11:1.
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Jörg Lützner, Gerd Dinnebier, Albrecht Hartmann, Klaus-Peter Günther & Stephan Kirschner. (2009) Study rationale and protocol: prospective randomized comparison of metal ion concentrations in the patient's plasma after implantation of coated and uncoated total knee prostheses. BMC Musculoskeletal Disorders 10:1.
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C. von Schulze Pellengahr, A. Fottner, S. Utzschneider, M. Schmitt-Sody, W. Teske, T. Lichtinger & S.A. Esenwein. (2009) Zementfreie Endoprothetik des HüftgelenksUncemented arthroplasty of the hip. Der Orthopäde 38:5, pages 461-472.
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James R. Cerhan, Eric A. Engels, Wendy Cozen, Scott Davis, Richard K. Severson, Lindsay M. Morton, Gloria Gridley, Patricia Hartge & Martha Linet. (2008) Blood transfusion, anesthesia, surgery and risk of non-Hodgkin lymphoma in a population-based case-control study. International Journal of Cancer 123:4, pages 888-894.
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Christian P. Delaunay, François Bonnomet, Philippe Clavert, Philippe Laffargue & Henri Migaud. (2008) THA Using Metal-on-Metal Articulation in Active Patients Younger Than 50 Years. Clinical Orthopaedics and Related Research 466:2, pages 340-346.
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Tracy Onega, John Baron & Todd MacKenzie. (2006) Cancer after Total Joint Arthroplasty: A Meta-analysis. Cancer Epidemiology, Biomarkers & Prevention 15:8, pages 1532-1537.
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TI Visuri, E Pukkala, P Pulkkinen & P Paavolainen. (2006) Cancer incidence and causes of death among total hip replacement patients: A review based on Nordic cohorts with a special emphasis on metal-on-metal bearings. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 220:2, pages 399-407.
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M J Goldacre, C J Wotton, V Seagroatt & D Yeates. (2005) Cancer following hip and knee arthroplasty: record linkage study. British Journal of Cancer 92:7, pages 1298-1301.
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