386
Views
66
CrossRef citations to date
0
Altmetric
Research Article

Vestibular and Cochlear Toxicity of Aminoglycosides - A review

Pages 904-911 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

C Rogers & L Petersen. (2011) Aminoglycoside-induced balance deficits: a review of vestibulotoxicity. South African Family Practice 53:5, pages 419-424.
Read now
Masamichi Kobayashi, Michihiko Sone, Masayuki Umemura, Toshitaka Nabeshima, Tsutomu Nakashima & Sten Hellström. (2008) Comparisons of cochleotoxicity among three gentamicin compounds following intratympanic application. Acta Oto-Laryngologica 128:3, pages 245-249.
Read now
Leif Nordang & Matti Anniko. (2005) Nitro-L-arginine methyl ester: A potential protector against gentamicin ototoxicity. Acta Oto-Laryngologica 125:10, pages 1033-1038.
Read now
Tsutomu Nakashima, Hayato Misawa, Michihiko Sone, Masamichi Kobayashi & Makoto Sigiura. (2004) Treatment of the inner ear through the middle ear: what have we learnt from the gentamicin approach?. Audiological Medicine 2:3, pages 162-164.
Read now
Masamichi Kobayashi, Masayuki Umemura, Michihiko Counter, Sone Klason & Tsutomu Nakashima. (2003) Differing Effects on the Inner Ear of Three Gentamicin Compounds: GM-C1, -C2 and -C1a.. Acta Oto-Laryngologica 123:8, pages 916-922.
Read now
Brian A. Hunter, Seahyoung Lee, Rick M. Odland & Steven K. Juhn. (2003) Estimation of Perilymph Concentration of Agents Applied to the Round Window Membrane by Microdialysis. Acta Oto-Laryngologica 123:4, pages 453-458.
Read now

Articles from other publishers (60)

Pelin Koçdor, Esra Özkan, Fatmanur Akpunar, Evren Hızal & Yasemin Gürsoy Özdemir. (2023) Protective Effects of Infliximab Against Kanamycin-Induced Ototoxicity in Rats. Otology & Neurotology 44:7, pages e463-e470.
Crossref
David Bächinger, Raphael Jecker, Jean-Christoph Hannig, Andreas Werner, Horst Hildebrandt, Michael Eidenbenz, Martin Kompis, Tobias Kleinjung & Dorothe Veraguth. (2022) Der „Professional Ear User“ – Implikationen für die Prävention, Diagnostik und Therapie von OhrerkrankungenThe professional ear user—implications for the prevention, diagnosis, and treatment of ear diseases. HNO 70:12, pages 891-902.
Crossref
Laura Leyssens, Bart Vinck, Catherine Van Der Straeten, Ingeborg Dhooge, Floris L. Wuyts, Philip Winnock de Grave, Filiep Bataillie, Jan Van Melkebeek, Koen De Smet, Ruth Van Hecke, Maya Danneels & Leen Maes. (2022) Assessing the Clinical Value of Objective and Patient-Reported Audiovestibular Outcome Measures in the Risk Estimation of Systemic Cobalt Toxicity for Patients With a Metal-on-Metal Hip Implant. Ear & Hearing 43:5, pages 1502-1514.
Crossref
Juliana Moreira Mendonça-Gomes, Amanda Pereira da Costa Araújo, Thiarlen Marinho da Luz, Ives Charlie-Silva, Helyson Lucas Bezerra Braz, Roberta Jeane Bezerra Jorge, Mohamed Ahmed Ibrahim Ahmed, Rafael Henrique Nóbrega, Christoph F.A. Vogel & Guilherme Malafaia. (2021) Environmental impacts of COVID-19 treatment: Toxicological evaluation of azithromycin and hydroxychloroquine in adult zebrafish. Science of The Total Environment 790, pages 148129.
Crossref
Desi P Schoo, Brian M. Lin & Yuri Agrawal. (2021) Intratympanic gentamicin injections. Operative Techniques in Otolaryngology-Head and Neck Surgery 32:2, pages 99-103.
Crossref
V. Tallandier, M. Chalansonnet, L. Merlen, S. Boucard, A. Thomas, P. Campo & B. Pouyatos. (2021) An in vitro model to assess the peripheral vestibulotoxicity of aromatic solvents. NeuroToxicology 84, pages 105-113.
Crossref
Jing Kong, Zhuo-Xun Wu, Liuya Wei, Zhe-Sheng Chen & Sabesan Yoganathan. (2020) Exploration of Antibiotic Activity of Aminoglycosides, in Particular Ribostamycin Alone and in Combination With Ethylenediaminetetraacetic Acid Against Pathogenic Bacteria. Frontiers in Microbiology 11.
Crossref
Waseema Mahomed, Barbara M Heinze, Bart HME Vinck & Anton Stoltz. (2020) Auditory, video head impulse test and vestibular evoked myogenic potentials findings in adults with human immunodeficiency virus. Auris Nasus Larynx 47:3, pages 367-376.
Crossref
Jacqueline M. Ogier, Paul J. Lockhart & Rachel A. Burt. (2020) Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice. Hearing Research 386, pages 107870.
Crossref
Laura Leyssens, Bart Vinck, Catherine Van Der Straeten, Koen De Smet, Ingeborg Dhooge, Floris L. Wuyts, Hannah Keppler, Sofie Degeest, Romain Valette, Rebecca Lim & Leen Maes. (2020) The Ototoxic Potential of Cobalt From Metal-on-Metal Hip Implants: Objective Auditory and Vestibular Outcome. Ear & Hearing 41:1, pages 217-230.
Crossref
Siân R. Kitcher, Nerissa K. Kirkwood, Esra D. Camci, Patricia Wu, Robin M. Gibson, Van A. Redila, Julian A. Simon, Edwin W. Rubel, David W. Raible, Guy P. Richardson & Corné J. Kros. (2019) ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity. JCI Insight 4:15.
Crossref
J. Lesus, K. Arias, J. Kulaga, S. Sobkiv, A. Patel, V. Babu, A. Kambalyal, M. Patel, F. Padron, P. Mozaffari, A. Jayakumar, L. Ghatalah, N. Laban, R. Bahari, G. Perkins & A. Lysakowski. (2019) Why study inner ear hair cell mitochondria?Warum sollten die Mitochondrien der Innenohr-Haarzellen untersucht werden?. HNO 67:6, pages 429-433.
Crossref
Maria Ramirez & Marcelo Tolmasky. (2017) Amikacin: Uses, Resistance, and Prospects for Inhibition. Molecules 22:12, pages 2267.
Crossref
Ruth Van HeckeVincent Van RompaeyFloris L. WuytsLaura LeyssensLeen Maes. (2017) Systemic Aminoglycosides-Induced Vestibulotoxicity in Humans. Ear & Hearing 38:6, pages 653-662.
Crossref
Nerissa K. Kirkwood, Molly O'Reilly, Marco Derudas, Emma J. Kenyon, Rosemary Huckvale, Sietse M. van Netten, Simon E. Ward, Guy P. Richardson & Corné J. Kros. (2017) d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity. Frontiers in Cellular Neuroscience 11.
Crossref
Jaynee A. Handelsman, Samya Z. Nasr, Crystal Pitts & William M. King. (2017) Prevalence of hearing and vestibular loss in cystic fibrosis patients exposed to aminoglycosides. Pediatric Pulmonology 52:9, pages 1157-1162.
Crossref
E. B. King, R. K. Shepherd, D. J. Brown & J. B. Fallon. (2017) Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs. Journal of the Association for Research in Otolaryngology 18:2, pages 291-299.
Crossref
M Turan, E Ciğer, S Arslanoğlu, H Börekci & K Önal. (2016) Could edaravone prevent gentamicin ototoxicity? An experimental study. Human & Experimental Toxicology 36:2, pages 123-127.
Crossref
Allison B. Coffin & John Ramcharitar. 2016. Fish Hearing and Bioacoustics. Fish Hearing and Bioacoustics 419 437 .
Ulf-Rüdiger Heinrich, Irene Schmidtmann, Sebastian Strieth & Kai Helling. (2015) Cell-specific accumulation patterns of gentamicin in the guinea pig cochlea. Hearing Research 326, pages 40-48.
Crossref
Qunfeng Cai, R Robert Vethanayagam, Shuzhi Yang, Jonathan Bard, Jennifer Jamison, Daniel Cartwright, Youyi Dong & Bo Hua Hu. (2014) Molecular profile of cochlear immunity in the resident cells of the organ of Corti. Journal of Neuroinflammation 11:1.
Crossref
Brian W. Blakley, Saad Alsaleh, Zameel Dewji, Kaiser Qureshy, Sylvie Berard & Ling Xie. (2013) Steroids in aminoglycoside‐containing ear drops: Do they reduce cochlear toxicity?. The Laryngoscope 124:5, pages 1209-1213.
Crossref
V Kahya, B Ozucer, R Dogan, A Meric, M Yuksel, O Gedikli & O Ozturan. (2014) Pomegranate extract: a potential protector against aminoglycoside ototoxicity. The Journal of Laryngology & Otology 128:1, pages 43-48.
Crossref
Qunfeng Cai, Bo Wang, Minal Patel, Shi Ming Yang & Bo Hua Hu. (2013) RNAlater facilitates microdissection of sensory cell-enriched samples from the mouse cochlea for transcriptional analyses. Journal of Neuroscience Methods 219:2, pages 240-251.
Crossref
Audrey Chan, Jason Cross, Yong He, Blaise Lippa & Dominic Ryan. 2013. Drug Discovery. Drug Discovery 389 438 .
D. Dulon, I. Mosnier & D. Bouccara. (2013) Ototoxicidad farmacológica. EMC - Otorrinolaringología 42:1, pages 1-13.
Crossref
H.A. Kirst & N.E. Allen. 2013. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
D. Dulon, I. Mosnier & D. Bouccara. (2012) Ototoxicité médicamenteuse. EMC - Oto-rhino-laryngologie 7:4, pages 1-12.
Crossref
Ulf-Rüdiger Heinrich & Kai Helling. (2012) Nitric oxide – A versatile key player in cochlear function and hearing disorders. Nitric Oxide 27:2, pages 106-116.
Crossref
Luisa Giari, Bahram Sayyaf Dezfuli, Laura Astolfi & Alessandro Martini. (2011) Ultrastructural effects of cisplatin on the inner ear and lateral line system of zebrafish ( Danio rerio ) larvae . Journal of Applied Toxicology 32:4, pages 293-299.
Crossref
Eliana S. Armstrong, Corwin F. Kostrub, Robert T. Cass, Heinz E. Moser, Alisa W. Serio & George H. Miller. 2012. Antibiotic Discovery and Development. Antibiotic Discovery and Development 229 269 .
Kai Helling, Karl Wodarzcyk, Jürgen Brieger, Irene Schmidtmann, Huige Li, Wolf J. Mann & Ulf-Rüdiger Heinrich. (2011) Doxycycline reduces nitric oxide production in guinea pig inner ears. Auris Nasus Larynx 38:6, pages 671-677.
Crossref
E. B. King, A. N. Salt, H. T. Eastwood & S. J. O’Leary. (2011) Direct Entry of Gadolinium into the Vestibule Following Intratympanic Applications in Guinea Pigs and the Influence of Cochlear Implantation. Journal of the Association for Research in Otolaryngology 12:6, pages 741-751.
Crossref
Kelly C. Wade & Daniel K. BenjaminJr.Jr.. 2011. Infectious Diseases of the Fetus and Newborn. Infectious Diseases of the Fetus and Newborn 1160 1211 .
Chi-Te Lin, Yi-Ho Young, Po-Wen Cheng & June-Horng Lue. (2010) Effects of gentamicin on guinea pig vestibular ganglion function and on substance P and neuropeptide Y. Journal of Chemical Neuroanatomy 40:4, pages 286-292.
Crossref
Maria S. Ramirez & Marcelo E. Tolmasky. (2010) Aminoglycoside modifying enzymes. Drug Resistance Updates 13:6, pages 151-171.
Crossref
Po-Wen Cheng, June-Horng Lue, Chi-Te Lin, An-Shiou Day & Yi-Ho Young. (2010) Assessment of gentamicin-induced vestibulotoxicity by click and galvanic vestibular-evoked myogenic potentials: A guinea pig investigation. NeuroToxicology 31:1, pages 121-125.
Crossref
Anil K. Lalwani & John F. McGuire. 2010. Cummings Otolaryngology - Head and Neck Surgery. Cummings Otolaryngology - Head and Neck Surgery 2179 2193 .
Kim M. Keeling & David M. Bedwell. 2010. Recoding: Expansion of Decoding Rules Enriches Gene Expression. Recoding: Expansion of Decoding Rules Enriches Gene Expression 123 146 .
Barbara Susan Robinson, Jeanne L. Cook, Cynthia McCormick Richburg & Stephen E. Price. (2009) Use of an Electrotactile Vestibular Substitution System to Facilitate Balance and Gait of an Individual with Gentamicin-Induced Bilateral Vestibular Hypofunction and Bilateral Transtibial Amputation. Journal of Neurologic Physical Therapy 33:3, pages 150-159.
Crossref
Jacinda B Sampson, Orly Vardeny & Kevin M Flanigan. (2009) Aminoglycosides and other nonsense suppression therapies for the treatment of dystrophinopathy. Cochrane Database of Systematic Reviews.
Crossref
Kelly N. Owens, Allison B. Coffin, Lisa S. Hong, Keri O’Connell Bennett, Edwin W Rubel & David W. Raible. (2009) Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways. Hearing Research 253:1-2, pages 32-41.
Crossref
Kelly N. Owens, Felipe Santos, Brock Roberts, Tor Linbo, Allison B. Coffin, Anna J. Knisely, Julian A. Simon, Edwin W. Rubel & David W. Raible. (2008) Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death. PLoS Genetics 4:2, pages e1000020.
Crossref
Xiang Wang, Shuping Jia, Benjamin Currall, Shiming Yang & David Z.Z. He. (2007) Streptomycin and gentamicin have no immediate effect on outer hair cell electromotility. Hearing Research 234:1-2, pages 52-58.
Crossref
Giuseppe Magliulo, Donato Parrotto, Mario Gagliardi & Francesca Romana Alla. (2016) Selective Damage of the Vestibular Apparatus Following Toxic Effects of Streptomycin. Otolaryngology–Head and Neck Surgery 137:1, pages 173-174.
Crossref
H.A. Kirst & N.E. Allen. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 629 652 .
Ming Du, Kim M. Keeling, Liming Fan, Xiaoli Liu, Timea Kovaçs, Eric Sorscher & David M. Bedwell. (2006) Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model. Journal of Molecular Medicine 84:7, pages 573-582.
Crossref
Pedro P. Hernández, Virginia Moreno, Francisco A. Olivari & Miguel L. Allende. (2006) Sub-lethal concentrations of waterborne copper are toxic to lateral line neuromasts in zebrafish (Danio rerio). Hearing Research 213:1-2, pages 1-10.
Crossref
Stig Å. Severinsen, Mette Kirkegaard & Jens R. Nyengaard. (2006) 2,3-Dihydroxybenzoic acid attenuates kanamycin-induced volume reduction in mouse utricular type I hair cells. Hearing Research 212:1-2, pages 99-108.
Crossref
Walter Marcotti, Sietse M. Van Netten & Corné J. Kros. (2005) The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano 
‐electrical transducer channels. The Journal of Physiology 567:2, pages 505-521.
Crossref
Steven Gabardi & Stuart Abramson. (2005) Drug Dosing in Chronic Kidney Disease. Medical Clinics of North America 89:3, pages 649-687.
Crossref
Avik Banerjee & Lorne S. Parnes. (2004) The biology of intratympanic drug administration and pharmacodynamics of round window drug absorption. Otolaryngologic Clinics of North America 37:5, pages 1035-1051.
Crossref
Peter S. Roland. (2004) New Developments in our Understanding of Ototoxicity. Ear, Nose & Throat Journal 83:9_suppl_4, pages 15-17.
Crossref
Kai Ming Chow, Cheuk Chun Szeto, Andrew Che-Fai Hui & Philip Kam-Tao Li. (2004) Mechanisms of antibiotic neurotoxicity in renal failure. International Journal of Antimicrobial Agents 23:3, pages 213-217.
Crossref
Markus L. Y. M. Oei, Hans M. Segenhout, Freark Dijk, Ietse Stokroos, Johannes J. L. van der Want & Frans W. J. Albers. (2004) Functional and Anatomic Alterations in the Gentamicin-Damaged Vestibular System in the Guinea Pig. Otology & Neurotology 25:1, pages 57-64.
Crossref
John Turnidge. (2003) Pharmacodynamics and dosing of aminoglycosides. Infectious Disease Clinics of North America 17:3, pages 503-528.
Crossref
Peter S. Roland. (2003) Characteristics of Systemic and Topical Agents Implicated in Toxicity of the Middle and Inner ear. Ear, Nose & Throat Journal 82:1_suppl, pages 3-8.
Crossref
Yoko Kitamura, Masa-aki Teranishi, Michihiko Sone & Tsutomu Nakashima. (2002) Round window membrane in young and aged C57BL/6 mice. Hearing Research 174:1-2, pages 142-148.
Crossref
B. Pilawa, E. Buszman, D. Wrześniok, M. Latocha & T. Wilczok. (2002) Application of EPR spectroscopy to examination of gentamicin and kanamycin binding to DOPA-melanin. Applied Magnetic Resonance 23:2, pages 181-192.
Crossref
. (2001) Current Awareness. Pharmacoepidemiology and Drug Safety 10:3, pages 263-278.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.