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Acta Oto-Laryngologica Volume 121, 2001 - Issue 3
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Research Article

Perilymphatic Concentration of Gentamicin Administered Intratympanically in Guinea Pigs

Tatsuya Hibi, Toru Suzuki, Tsutomu Nakashima Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
Pages 336-341 | Published online: 08 Jul 2009

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Levent Naci Ozluoglu, Ismail Yilmaz, Babur Akkuzu & Ayşegul Haberal. (2006) Buffered papaverine facilitates passage of intratympanic dexamethasone to the inner ear. Acta Oto-Laryngologica 126:12, pages 1260-1265.
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Tsutomu Nakashima, Hayato Misawa, Michihiko Sone, Masamichi Kobayashi & Makoto Sigiura. (2004) Treatment of the inner ear through the middle ear: what have we learnt from the gentamicin approach?. Audiological Medicine 2:3, pages 162-164.
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Articles from other publishers (25)

Seong-Hun Jeong, Yoonjoong Kim, Ah-Ra Lyu, Sun-Ae Shin, Tae Hwan Kim, Yang Hoon Huh, A Reum Je, Akanksha Gajibhiye, Yang Yu, Yongde Jin, Min Jung Park & Yong-Ho Park. (2021) Junctional Modulation of Round Window Membrane Enhances Dexamethasone Uptake into the Inner Ear and Recovery after NIHL. International Journal of Molecular Sciences 22:18, pages 10061.
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Hyo-Jung Kim, Jin-Ok Lee & Ji-Soo Kim. (2021) Protective Effects of Deferoxamine on Vestibulotoxicity in Gentamicin-Induced Bilateral Vestibulopathy Rat Model. Frontiers in Neurology 12.
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Hisayoshi Ishizaki. (2021) Hearing Preservation After Intratympanic Gentamicin Treatment for Meniere’s Disease. Practica oto-rhino-laryngologica. Suppl. 156:0, pages 26-33.
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Pedro Marques, Maoli Duan, Nicolas Perez-Fernandez & Jorge Spratley. (2018) Gentamicin delivery to the inner ear: Does endolymphatic hydrops matter?. PLOS ONE 13:11, pages e0207467.
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A.N. Salt, J.J. Hartsock, R.M. Gill, E. King, F.B. Kraus & S.K. Plontke. (2016) Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig. Hearing Research 342, pages 101-111.
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Cecilia Engmér Berglin, Göran Laurell, Tobias Bramer, Katarina Edsman, S. Allen Counter, Tomas Klason & Andreas Ekborn. (2014) Magnetic Resonance Imaging of the Middle and Inner Ear After Intratympanic Injection of a Gadolinium-Containing Gel. Otology & Neurotology 35:3, pages 526-532.
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Shayanne A. Lajud, Zhao Han, Fang-Lu Chi, Rende Gu, Danish A. Nagda, Orysia Bezpalko, Samudra Sanyal, Andres Bur, Ziying Han, Bert W. O'MalleyJr.Jr. & Daqing Li. (2013) A regulated delivery system for inner ear drug application. Journal of Controlled Release 166:3, pages 268-276.
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Jiwon Chang, Ji Yun Yang, June Choi, Hak Hyun Jung & Gi Jung Im. (2011) Calcium imaging in gentamicin ototoxicity: Increased intracellular calcium relates to oxidative stress and late apoptosis. International Journal of Pediatric Otorhinolaryngology 75:12, pages 1616-1622.
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Marta Martini, Rita Canella, Ivo Prigioni, Giancarlo Russo, Elisa Tavazzani, Riccardo Fesce & Maria Lisa Rossi. (2011) Acute effects of gentamicin on the ionic currents of semicircular canal hair cells in the frog. Hearing Research 282:1-2, pages 151-160.
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Feng Zhai, Jian-Ping Liu, Chun-Fu Dai, Qi Wang & Peter S. Steyger. (2010) Evidence-Based Modification of Intratympanic Gentamicin Injections in Patients With Intractable Vertigo. Otology & Neurotology 31:4, pages 642-648.
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Anil K. Lalwani & John F. McGuire. 2010. Cummings Otolaryngology - Head and Neck Surgery. Cummings Otolaryngology - Head and Neck Surgery 2179 2193 .
Mao-li Duan & Chen Zhi-qiang. (2009) Permeability of round window membrane and its role for drug delivery: our own findings and literature review. Journal of Otology 4:1, pages 34-43.
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Yoon Chan RahBong Jik KimJae-Jin SongSung Kwang HongJi Soo KimJa-Won Koo. (2009) Treatment of Meniere's Disease and Intratympanic Gentamicin Injection. Korean Journal of Otorhinolaryngology-Head and Neck Surgery 52:12, pages 949.
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Stefan K. Plontke, Robert Mynatt, Ruth M. Gill, Stefan Borgmann & Alec N. Salt. (2009) Concentration Gradient Along the Scala Tympani After Local Application of Gentamicin to the Round Window Membrane. The Laryngoscope 117:7, pages 1191-1198.
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Hartmut Hahn, Bernd Kammerer, Andre DiMauro, Alec N. Salt & Stefan K. Plontke. (2006) Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hearing Research 212:1-2, pages 236-244.
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Alec N. Salt & Stefan K.R. Plontke. (2005) Local inner-ear drug delivery and pharmacokinetics. Drug Discovery Today 10:19, pages 1299-1306.
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S. Plontke. (2005) Untersuchungen zur lokalen Medikamentenapplikation an das Innenohr. HNO 53:10, pages 837-844.
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Timo P. Hirvonen, Lloyd B. Minor, Timothy E. Hullar & John P. Carey. (2005) Effects of Intratympanic Gentamicin on Vestibular Afferents and Hair Cells in the Chinchilla. Journal of Neurophysiology 93:2, pages 643-655.
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Paul H Van de Heyning, Floris Wuyts & An Boudewyns. (2005) Surgical treatment of Ménièreʼs disease. Current Opinion in Neurology 18:1, pages 23-28.
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John Carey. (2004) Intratympanic gentamicin for the treatment of Ménière's disease and other forms of peripheral vertigo. Otolaryngologic Clinics of North America 37:5, pages 1075-1090.
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Avik Banerjee & Lorne S. Parnes. (2004) The biology of intratympanic drug administration and pharmacodynamics of round window drug absorption. Otolaryngologic Clinics of North America 37:5, pages 1035-1051.
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Zhiqiang Chen, Maoli Duan, Howsung Lee, Runsheng Ruan & Mats Ulfendahl. (2003) Pharmacokinetics of Caroverine in the Inner Ear and Its Effects on Cochlear Function after Systemic and Local Administrations in Guinea Pigs. Audiology and Neurotology 8:1, pages 49-56.
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Yoko Kitamura, Masa-aki Teranishi, Michihiko Sone & Tsutomu Nakashima. (2002) Round window membrane in young and aged C57BL/6 mice. Hearing Research 174:1-2, pages 142-148.
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Stefan K. R. Plontke, Arthur W. Wood & Alec N. Salt. (2002) Analysis of Gentamicin Kinetics in Fluids of the Inner Ear with Round Window Administration. Otology & Neurotology 23:6, pages 967-974.
Crossref
Matthew C Holley. (2002) Application of new biological approaches to stimulate sensory repair and protection. British Medical Bulletin 63:1, pages 157-169.
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