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Research Article

Topical Treatment with Growth Factors for Tympanic Membrane Perforations: Progress Towards Clinical Application

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Pages 586-599 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Peter Luke Santa Maria, Sungwoo Kim & Yunzhi Peter Yang. (2016) No systemic exposure of transtympanic heparin-binding epidermal growth factor like growth factor. Drug and Chemical Toxicology 39:4, pages 451-454.
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Bing Mei Teh, Yi Shen, Peter L Friedland, Marcus D Atlas & Robert J Marano. (2012) A review on the use of hyaluronic acid in tympanic membrane wound healing. Expert Opinion on Biological Therapy 12:1, pages 23-36.
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Zheng-Cai Lou, Yun-xing Hu & Yong-Mei Tang. (2011) Effect of treatment at different time intervals for traumatic tympanic membrane perforation on the closure. Acta Oto-Laryngologica 131:10, pages 1032-1039.
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Jamel Tahar Aissa & Malou Hultcrantz. (2009) Acute tympanic membrane perforations and the early immunological response in rats. Acta Oto-Laryngologica 129:11, pages 1192-1197.
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Anisur Rahman, Petri Olivius, Joris Dirckx, Magnus Von Unge & Malou Hultcrantz. (2008) Stem cells and enhanced healing of chronic tympanic membrane perforation. Acta Oto-Laryngologica 128:4, pages 352-359.
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Articles from other publishers (39)

Chul Ho Jang, Wonjin Kim, Changjong Moon & Geunhyung Kim. (2022) Bioprinted Collagen-Based Cell-Laden Scaffold With Growth Factors for Tympanic Membrane Regeneration in Chronic Perforation Model. IEEE Transactions on NanoBioscience 21:3, pages 370-379.
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Shivesh Anand, Serena Danti, Lorenzo Moroni & Carlos Mota. (2022) Regenerative therapies for tympanic membrane. Progress in Materials Science 127, pages 100942.
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David Shahal, Stefania Goncalves & Simon I. Angeli. (2022) Mesenchymal Stem Cells for Treatment of Delayed-Healing Tympanic Membrane Perforations Using Hyaluronate-based Laminas as a Delivery System: An Animal Model With Histopathologic Study. Otology & Neurotology 43:4, pages e497-e506.
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Zhengcai Lou, Zihan Lou, Yumeng Jiang & Zhengnong Chen. (2021) FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review. Stem Cells International 2021, pages 1-15.
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Xu Yao, Bing Mei Teh, Huan Li, Yi Hu, Juntao Huang, Cuiting Lv, Shizhong Bu, Minghao Zheng & Yi Shen. (2020) Acellular Collagen Scaffold With Basic Fibroblast Growth Factor for Repair of Traumatic Tympanic Membrane Perforation in a Rat Model. Otolaryngology–Head and Neck Surgery 164:2, pages 381-390.
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Juntao Huang, Yunbin Shi, Linrong Wu, Cuiting Lv, Yi Hu & Yi Shen. (2021) Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis. PLOS ONE 16:1, pages e0245968.
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Yachao Liu. (2020) Epidermal growth factor on the healing of human subacute tympanic membrane perforation. American Journal of Otolaryngology 41:2, pages 102399.
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Mohammed Bassiouny, Nahed Badour & Yasser Shewel. (2018) Comparative immunohistochemical study of acquired cholesteatoma in children and adults. The Egyptian Journal of Otolaryngology 34:2, pages 116-121.
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Dan ZhangZhen HuangPeng SunHaiping HuangYunmei ZhangJianwu DaiJisheng LiuQin Shi. (2017) Acceleration of Healing of Traumatic Tympanic Membrane Perforation in Rats by Implanted Collagen Membrane Integrated with Collagen-Binding Basic Fibroblast Growth Factor. Tissue Engineering Part A 23:1-2, pages 20-29.
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A. Ayala-Montes de Oca, S.N. Alla & J.C. López-Valdés. (2016) Effectiveness of topical phenytoin therapy versus platelet-rich plasma for tympanic perforations closure: Comparative study. Revista Médica del Hospital General de México 79:4, pages 183-188.
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Lili Lin, Nikola Skakavac, Xiaoyang Lin, Dong Lin, Mia C. Borlongan, Cesar V. Borlongan & Chuanhai Cao. (2016) Acupuncture-Induced Analgesia: The Role of Microglial Inhibition. Cell Transplantation 25:4, pages 621-628.
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Maria Makuszewska, Magdalena Sokołowska, Elżbieta Hassmann-Poznańska, Izabela Bialuk, Bożena Skotnicka, Tomasz Bonda, Joanna Reszeć & Maria Małgorzata Winnicka. (2015) Enhanced expression of hepatocyte growth factor in the healing of experimental acute tympanic membrane perforation. International Journal of Pediatric Otorhinolaryngology 79:7, pages 987-992.
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Nobuhiro Hakuba, Keizo Ikemune, Masahiro Okada & Naohito Hato. (2015) Use of ambulatory anesthesia with manually assisted ventilation for tympanic membrane regeneration therapy in children. American Journal of Otolaryngology 36:2, pages 153-157.
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Felician Chirteş, Veronica Trombitas, Diana Vlad, Flaviu Tabaran, Cristian Berce & Silviu Albu. (2014) Efficiency of Cryotherapy in Avoiding Myringotomy Closure in Rats. Indian Journal of Otolaryngology and Head & Neck Surgery 67:1, pages 68-71.
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Sunny Kumar, Sunil T. Narishetty & Hemachand Tummala. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 337 352 .
Yue Shen, Yongzhi Guo, Malgorzata Wilczynska, Jinan Li, Sten Hellström & Tor Ny. (2014) Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice. Journal of Translational Medicine 12:1.
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Nobuhiro Hakuba, Yasuhiko Tabata, Naohito Hato, Takashi Fujiwara & Kiyofumi Gyo. (2014) Gelatin Hydrogel With Basic Fibroblast Growth Factor for Tympanic Membrane Regeneration. Otology & Neurotology 35:3, pages 540-544.
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Bing Mei TehRobert J. MaranoYi ShenPeter L. FriedlandRodney J. DilleyMarcus D. Atlas. (2013) Tissue Engineering of the Tympanic Membrane. Tissue Engineering Part B: Reviews 19:2, pages 116-132.
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Bing Mei Teh, Sharon L. Redmond, Yi Shen, Marcus D. Atlas, Robert J. Marano & Rodney J. Dilley. (2013) TGF-α/HA complex promotes tympanic membrane keratinocyte migration and proliferation via ErbB1 receptor. Experimental Cell Research 319:6, pages 790-799.
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Katarzyna Guzińska-Ustymowicz, Agnieszka Kurzyna, Krzysztof Trzpis, Andrzej Kemona & Elżbieta Hassmann-Poznańska. (2013) Czynnik wzrostu komórek rogowaciejących i jego receptor w perlaku ucha środkowego. Otolaryngologia Polska 67:2, pages 67-71.
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Kyoung Ho Park. (2013) Endogenous Stem Cells in the Ear. Korean Journal of Otorhinolaryngology-Head and Neck Surgery 56:12, pages 749.
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Saumil N. Merchant & John J. Rosowski. 2013. The Middle Ear. The Middle Ear 253 272 .
Yue Shen, Yongzhi Guo, Chun Du, Malgorzata Wilczynska, Sten Hellström & Tor Ny. (2012) Mice Deficient in Urokinase-Type Plasminogen Activator Have Delayed Healing of Tympanic Membrane Perforations. PLoS ONE 7:12, pages e51303.
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J. Tahar Aissa & M. Hultcrantz. (2012) Healing of laser-induced tympanic membrane perforations in rats: No contribution of granulocyte colony-stimulating factor or Gelfoam®. International Journal of Pediatric Otorhinolaryngology 76:7, pages 963-968.
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Zhengcai Lou, Yongmei Tang & Xiaohong Wu. (2012) Analysis of the effectiveness of basic fibroblast growth factor treatment on traumatic perforation of the tympanic membrane at different time points. American Journal of Otolaryngology 33:2, pages 244-249.
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Zafarullah Beigh, ManzoorAhmad Malik, Aamir Yousuf & RafiqAhmad Pampori. (2012) Role of topical heparine in healing of traumatic tympanic membrane perforations. Indian Journal of Otology 18:3, pages 143.
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Christof Röösli, Toni von Büren, Nicolas B. Gassmann & Alex M. Huber. (2011) The Impact of Platelet-Derived Growth Factor on Closure of Chronic Tympanic Membrane Perforations. Otology & Neurotology 32:8, pages 1224-1229.
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Zhengcai Lou, Lianfang Xu, Jian Yang & Xiaohong Wu. (2011) Outcome of children with edge-everted traumatic tympanic membrane perforations following spontaneous healing versus fibroblast growth factor-containing gelfoam patching with or without edge repair. International Journal of Pediatric Otorhinolaryngology 75:10, pages 1285-1288.
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Peter L. Santa Maria, Sharon L. Redmond, Russell L. McInnes, Marcus D. Atlas & Reza Ghassemifar. (2011) Tympanic membrane wound healing in rats assessed by transcriptome profiling. The Laryngoscope 121:10, pages 2199-2213.
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Peter L. Santa Maria, Sharon L. Redmond, Marcus D. Atlas & Reza Ghassemifar. (2010) Keratinocyte growth factor 1, fibroblast growth factor 2 and 10 in the healing tympanic membrane following perforation in rats. Journal of Molecular Histology 42:1, pages 47-58.
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Peter L. Santa Maria, Sharon L. Redmond, Marcus D. Atlas & Reza Ghassemifar. (2010) The role of epidermal growth factor in the healing tympanic membrane following perforation in rats. Journal of Molecular Histology 41:6, pages 309-314.
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Kyu-Sup Cho, Dong-Gun Lee, Dong-Hoon Shin, Young-Dae Park & Kyong-Myong Chon. (2010) The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation. American Journal of Otolaryngology 31:5, pages 309-314.
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Nobuhiro Hakuba, Michitaka Iwanaga, Shinzo Tanaka, Yasuyuki Hiratsuka, Yohei Kumabe, Masaya Konishi, Yusuke Okanoue, Nao Hiwatashi & Tadahiko Wada. (2010) Basic Fibroblast Growth Factor Combined With Atelocollagen for Closing Chronic Tympanic Membrane Perforations in 87 Patients. Otology & Neurotology 31:1, pages 118-121.
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E Erkilet, M Koyuncu, S Atmaca & M Yarim. (2008) Platelet-rich plasma improves healing of tympanic membrane perforations: experimental study. The Journal of Laryngology & Otology 123:5, pages 482-487.
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Billy Giles. (2007) Wound Healing in Spontaneous Perforation or Myringotomy and Middle Ear Reconstruction. Ear, Nose & Throat Journal 86:11_suppl, pages 30-32.
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Anisur Rahman, Magnus von Unge, Petri Olivius, Joris Dirckx & Malou Hultcrantz. (2007) Healing time, long-term result and effects of stem cell treatment in acute tympanic membrane perforation. International Journal of Pediatric Otorhinolaryngology 71:7, pages 1129-1137.
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Joshua D. Safer, Tara M. Crawford & Michael F. Holick. (2005) Topical Thyroid Hormone Accelerates Wound Healing in Mice. Endocrinology 146:10, pages 4425-4430.
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Hung‐Pin Chi, Kuen‐Yao Ho, Chih‐Feng Ta, Ling‐Feng Wang, Ka‐Wo Lee, Wen‐Rei Kuo, Chee‐Yin Chai, Shu‐Chuan Wu & Shin‐Meng Tsai. (2009) Epidermal Growth Factor Expression in Middle Ear Cholesteatoma. The Kaohsiung Journal of Medical Sciences 20:1, pages 6-10.
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Sharon L. Bourke, Mohammad Al-Khalili, Tonye Briggs, Bozena B. Michniak, Joachim Kohn & Laura A. Poole-Warren. (2015) A photo-crosslinked poly(vinyl alcohol) hydrogel growth factor release vehicle for wound healing applications. AAPS PharmSci 5:4, pages 101-111.
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