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Acta Oto-Laryngologica Volume 123, 2003 - Issue 2
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Original Paper

High Variability of Perilymphatic Entry of Neutral Molecules Through the Round Window

Larbi Chelikh INSERM EMI-U 0112, Faculté Xavier Bichat, FranceCorrespondence[email protected]
,
Marie Teixeira CHU Bellevue, AP-HP, Saint Etienne
,
Christian Martin Hôpital Beaujon, AP-HP, Clichy
,
Olivier Sterkers Pediatric ENT Department, Hôpital Robert Debré, AP-HP, Paris
,
Evelyne Ferrary INSERM EMI-U 0112, Faculté Xavier Bichat, France
&
Vincent Couloigner CHU Bellevue, AP-HP, Saint Etienne
Pages 199-202 | Published online: 08 Jul 2009

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Juan Dai, Wei Long, Zhongping Liang, Lu Wen, Fan Yang & Gang Chen. (2018) A novel vehicle for local protein delivery to the inner ear: injectable and biodegradable thermosensitive hydrogel loaded with PLGA nanoparticles. Drug Development and Industrial Pharmacy 44:1, pages 89-98.
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Hongzhuo Liu, Liang Feng, Gaurav Tolia, Mark R. Liddell, Jinsong Hao & S. Kevin Li. (2014) Evaluation of intratympanic formulations for inner ear delivery: methodology and sustained release formulation testing. Drug Development and Industrial Pharmacy 40:7, pages 896-903.
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Jun Yang, Hao Wu, Ping Zhang, Dong-Ming Hou, Jie Chen & Shun-Guo Zhang. (2008) The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration. Acta Oto-Laryngologica 128:5, pages 496-504.
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Articles from other publishers (20)

Hyun-Jin Lee, Munyoung Chang & Seog-Kyun Mun. (2023) Intratympanic injection for treatment of inner ear diseases. Journal of the Korean Medical Association 66:10, pages 589-596.
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Manish Gupta, Monica Gupta & Satish Kumar. (2020) Comparative Efficacy of intra-tympanic methylprednisolone injections in different concentrations on subjective cochlear tinnitus. IP Journal of Otorhinolaryngology and Allied Science 3:3, pages 91-96.
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Julia Clara Gausterer, Nodir Saidov, Navid Ahmadi, Chengjing Zhu, Michael Wirth, Gottfried Reznicek, Christoph Arnoldner, Franz Gabor & Clemens Honeder. (2020) Intratympanic application of poloxamer 407 hydrogels results in sustained N-acetylcysteine delivery to the inner ear. European Journal of Pharmaceutics and Biopharmaceutics 150, pages 143-155.
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Fabrice Piu & Kathie M. Bishop. (2019) Local Drug Delivery for the Treatment of Neurotology Disorders. Frontiers in Cellular Neuroscience 13.
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Daniele Bernardeschi, Yann Nguyen, Francesca Yoshie Russo, Isabelle Mosnier, Evelyne Ferrary & Olivier Sterkers. (2015) Cutaneous and Labyrinthine Tolerance of Bioactive Glass S53P4 in Mastoid and Epitympanic Obliteration Surgery: Prospective Clinical Study. BioMed Research International 2015, pages 1-6.
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Mia E. Miller & Julie Bykowski. (2014) Imaging Analysis of Ménière’s Disease. Current Otorhinolaryngology Reports 2:3, pages 152-161.
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John William Wood, Esperanza Bas, Chhavi Gupta, Yamil Selman, Adrien Eshraghi, Fred F. Telischi & Thomas R. Van De Water. (2014) Otoprotective Properties of Mannitol Against Gentamicin Induced Hair Cell Loss. Otology & Neurotology 35:5, pages e187-e194.
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Lihua Li, Jihao Ren, Tuanfang Yin & Wei Liu. (2012) Intratympanic dexamethasone perfusion versus injection for treatment of refractory sudden sensorineural hearing loss. European Archives of Oto-Rhino-Laryngology 270:3, pages 861-867.
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Shigetoshi Yoda, Sebahattin Cureoglu, Shigetaka Shimizu, Norimasa Morita, Hisaki Fukushima, Teruyuki Sato, Tamotsu Harada & Michael M. Paparella. (2011) Round Window Membrane in Ménière's Disease. Otology & Neurotology 32:1, pages 147-151.
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Amanj Saber, Sabina P. Strand & Mats Ulfendahl. (2010) Use of the biodegradable polymer chitosan as a vehicle for applying drugs to the inner ear. European Journal of Pharmaceutical Sciences 39:1-3, pages 110-115.
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Amanj Saber, Göran Laurell, Tobias Bramer, Katarina Edsman, Cecilia Engmér & Mats Ulfendahl. (2009) Middle Ear Application of a Sodium Hyaluronate Gel Loaded with Neomycin in a Guinea Pig Model. Ear & Hearing 30:1, pages 81-89.
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Alec N. Salt, Davud B. Sirjani, Jared J. Hartsock, Ruth M. Gill & Stefan K. Plontke. (2007) Marker retention in the cochlea following injections through the round window membrane. Hearing Research 232:1-2, pages 78-86.
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Stefan K. Plontke, Robert Mynatt, Ruth M. Gill, Stefan Borgmann & Alec N. Salt. (2009) Concentration Gradient Along the Scala Tympani After Local Application of Gentamicin to the Round Window Membrane. The Laryngoscope 117:7, pages 1191-1198.
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Alec N. Salt, Shane A. Hale & Stefan K.R. Plonkte. (2006) Perilymph sampling from the cochlear apex: A reliable method to obtain higher purity perilymph samples from scala tympani. Journal of Neuroscience Methods 153:1, pages 121-129.
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Hartmut Hahn, Bernd Kammerer, Andre DiMauro, Alec N. Salt & Stefan K. Plontke. (2006) Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hearing Research 212:1-2, pages 236-244.
Crossref
T. Lenarz. 2006. Vestibularfunktion. Vestibularfunktion 215 221 .
S. Plontke. (2005) Untersuchungen zur lokalen Medikamentenapplikation an das Innenohr. HNO 53:10, pages 837-844.
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Joshua P Light & Herbert Silverstein. (2004) Transtympanic perfusion: indications and limitations. Current Opinion in Otolaryngology & Head and Neck Surgery 12:5, pages 378-383.
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Avik Banerjee & Lorne S. Parnes. (2004) The biology of intratympanic drug administration and pharmacodynamics of round window drug absorption. Otolaryngologic Clinics of North America 37:5, pages 1035-1051.
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David M. Barrs. (2004) Intratympanic corticosteroids for Meniere's disease and vertigo. Otolaryngologic Clinics of North America 37:5, pages 955-972.
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