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Article

Protective Effects of α-Tocopherol Against Gentamicin-induced Oto-vestibulo Toxicity: An Experimental Study

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Pages 192-198 | Published online: 08 Jul 2009

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Anna Rita Fetoni, Sara Letizia Maria Eramo, Fabiola Paciello, Rolando Rolesi, Diana Troiani & Gaetano Paludetti. (2015) Role of antioxidant supplementation in preventing noise induced hearing loss. Hearing, Balance and Communication 13:4, pages 160-165.
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Anna R. Fetoni, Massimo Ralli, Bruno Sergi, Claudio Parrilla, Diana Troiani & Gaetano Paludetti. (2008) Protective properties of antioxidant drugs in noise-induced hearing loss in the guinea pig. Audiological Medicine 6:4, pages 271-277.
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A. R. Fetoni, B. Sergi, A. Ferraresi, G. Paludetti & D. Troiani. (2004) Protective effects of α-tocopherol and tiopronin against cisplatin-induced ototoxicity. Acta Oto-Laryngologica 124:4, pages 421-426.
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B. Sergi, A. R. Fetoni, A. Ferraresi, D. Troiani, G. B. Azzena, G. Paludetti & M. Maurizi. (2004) The role of antioxidants in protection from ototoxic drugs. Acta Oto-Laryngologica 124:sup552, pages 42-45.
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Liao-Chen Chen, Hwei-Hsien Chen & Ming-Huan Chan. (2024) Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish. Archives of Toxicology.
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Anna Pisani, Fabiola Paciello, Raffaele Montuoro, Rolando Rolesi, Jacopo Galli & Anna Rita Fetoni. (2023) Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic. Life 13:4, pages 1035.
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Fabiola Paciello, Cristian Ripoli, Anna Rita Fetoni & Claudio Grassi. (2023) Redox Imbalance as a Common Pathogenic Factor Linking Hearing Loss and Cognitive Decline. Antioxidants 12:2, pages 332.
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Jinkyung Kim, Sriram Hemachandran, Alan G. Cheng & Anthony J. Ricci. (2022) Identifying targets to prevent aminoglycoside ototoxicity. Molecular and Cellular Neuroscience 120, pages 103722.
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Xiaolong Fu, Peifeng Wan, Peipei Li, Jinpeng Wang, Siwei Guo, Yuan Zhang, Yachun An, Chao Ye, Ziyi Liu, Jiangang Gao, Jianming Yang, Jiangang Fan & Renjie Chai. (2021) Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides. Frontiers in Cellular Neuroscience 15.
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Gaëlle Naert, Marie-Pierre Pasdelou & Colleen G. Le Prell. (2019) Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise. The Journal of the Acoustical Society of America 146:5, pages 3743-3769.
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R.D. Frisina, M. Budzevich, X. Zhu, G.V. Martinez, J.P. Walton & D.A. Borkholder. (2018) Animal model studies yield translational solutions for cochlear drug delivery. Hearing Research 368, pages 67-74.
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Volker Noack, Kwang Pak, Rahul Jalota, Arwa Kurabi & Allen F. Ryan. (2017) An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity. Frontiers in Cellular Neuroscience 11.
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Katsuki Niwa, Takeshi Matsunobu, Takaomi Kurioka, Daisuke Kamide, Atsushi Tamura, Shin Tadokoro, Yasushi Satoh & Akihiro Shiotani. (2016) The beneficial effect of Hangesha-shin-to (TJ-014) in gentamicin-induced hair cell loss in the rat cochlea. Auris Nasus Larynx 43:5, pages 507-513.
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Robert Esterberg, Tor Linbo, Sarah B. Pickett, Patricia Wu, Henry C. Ou, Edwin W. Rubel & David W. Raible. (2016) Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death. Journal of Clinical Investigation 126:9, pages 3556-3566.
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Mustafa Sagit, Ferhat Korkmaz, Seren Gulsen Gürgen, Ramazan Gundogdu, Alper Akcadag & Ibrahim Ozcan. (2015) Quercetine attenuates the gentamicin-induced ototoxicity in a rat model. International Journal of Pediatric Otorhinolaryngology 79:12, pages 2109-2114.
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Yoon Chan Rah, June Choi, Myung Hoon Yoo, Gunhwee Yum, Saemi Park, Kyoung Ho Oh, Seung Hoon Lee, Soon Young Kwon, Seung Hyun Cho, Suhyun Kim & Hae-Chul Park. (2015) Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radical Biology and Medicine 89, pages 1176-1183.
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Ismail Kocyigit, Alperen Vural, Aydin Unal, Murat Hayri Sipahioglu, Hasan Esat Yucel, Samet Aydemir, Cevat Yazici, M. İlhan Sahin, Oktay Oymak & Bulent Tokgoz. (2014) Preventing amikacin related ototoxicity with N-acetylcysteine in patients undergoing peritoneal dialysis. European Archives of Oto-Rhino-Laryngology 272:10, pages 2611-2620.
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Najeeb A. Shirwany & Michael D. Seidman. 2015. Free Radicals in ENT Pathology. Free Radicals in ENT Pathology 57 89 .
Takaomi Kurioka, Takeshi Matsunobu, Yasushi Satoh, Katsuki Niwa & Akihiro Shiotani. (2014) Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neuroscience Research 89, pages 69-74.
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Mustafa Sagit, Ferhat Korkmaz, Seren Gulsen Gürgen, Mesut Kaya, Alper Akcadag & Ibrahim Ozcan. (2014) The protective role of thymoquinone in the prevention of gentamicin ototoxicity. American Journal of Otolaryngology 35:5, pages 603-609.
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C. G. Le Prell, C. Ojano-Dirain, E. W. Rudnick, M. A. Nelson, S. J. DeRemer, D. M. Prieskorn & J. M. Miller. (2014) Assessment of Nutrient Supplement to Reduce Gentamicin-Induced Ototoxicity. Journal of the Association for Research in Otolaryngology.
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Mukesh Kumar YadavJune ChoiJae-Jun Song. (2014) Protective Effect of Hexane and Ethanol Extract of Piper Longum L. on Gentamicin-Induced Hair Cell Loss in Neonatal Cultures . Clinical and Experimental Otorhinolaryngology 7:1, pages 13.
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Hongzhuo Liu, Jinsong Hao & Kevin S. Li. (2013) Current strategies for drug delivery to the inner ear. Acta Pharmaceutica Sinica B 3:2, pages 86-96.
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Tuba BayindirAliye FilizMustafa IrazSerdar KayaMehmet TanMahmut Tayyar Kalcioglu. (2013) Evaluation of the Protective Effect of Beta Glucan on Amikacin Ototoxicity Using Distortion Product Otoacoustic Emission Measurements in Rats. Clinical and Experimental Otorhinolaryngology 6:1, pages 1.
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M. E. Huth, A. J. Ricci & A. G. Cheng. (2011) Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection. International Journal of Otolaryngology 2011, pages 1-19.
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A.L. Poirrier, P. Van den Ackerveken, T.S. Kim, R. Vandenbosch, L. Nguyen, P.P. Lefebvre & B. Malgrange. (2010) Ototoxic drugs: Difference in sensitivity between mice and guinea pigs. Toxicology Letters 193:1, pages 41-49.
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Anna Rita Fetoni, Roberto Piacentini, Antonella Fiorita, Gaetano Paludetti & Diana Troiani. (2009) Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). Brain Research 1257, pages 108-116.
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Sung-Il NamDae-Kyu SongSung-Hee ParkJae-Hoon LeeWoo-Keun LeeEal-Maan KimJae-Sik Park. (2009) Characterization of Gentamicin-Induced Apoptosis in a Cochlear Cell Model. Korean Journal of Otolaryngology-Head and Neck Surgery 52:3, pages 207.
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Anna R. Fetoni, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Bruno Sergi, Giuseppe Tringali, Roberto Piacentini & Diana Troiani. (2008) Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E. NeuroReport 19:3, pages 277-281.
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Hiroaki Shimogori, Tsuyoshi Takemoto, Takefumi Mikuriya & Hiroshi Yamashita. (2007) Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (±)-α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid. European Journal of Pharmacology 554:2-3, pages 223-228.
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Bruno Sergi, Anna Rita Fetoni, Gaetano Paludetti, Aldo Ferraresi, Pierluigi Navarra, Alvaro Mordente & Diana Troiani. (2006) Protective properties of idebenone in noise-induced hearing loss in the guinea pig. NeuroReport 17:9, pages 857-861.
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P.M. Picciotti, A.R. Fetoni, G. Paludetti, F.I. Wolf, A. Torsello, D. Troiani, A. Ferraresi, R. Pola & B. Sergi. (2006) Vascular endothelial growth factor (VEGF) expression in noise-induced hearing loss. Hearing Research 214:1-2, pages 76-83.
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Leonard P. Rybak & Craig A. Whitworth. (2005) Ototoxicity: therapeutic opportunities. Drug Discovery Today 10:19, pages 1313-1321.
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Ömer Faruk Ünal, Seyed Mahmoud Ghoreishi, Ahmet Ataş, Nalan Akyürek, Gülen Akyol & Bülent Gürsel. (2005) Prevention of gentamicin induced ototoxicity by trimetazidine in animal model. International Journal of Pediatric Otorhinolaryngology 69:2, pages 193-199.
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M. Tariq, H. A. Khan, K. Al Moutaery & S. Al Deeb. (2004) Sodium benzoate attenuates iminodipropionitrile-induced behavioral syndrome in rats. Behavioural Pharmacology 15:8, pages 585-588.
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Michael D. Seidman & Prashant Vivek. (2004) Intratympanic treatment of hearing loss with novel and traditional agents. Otolaryngologic Clinics of North America 37:5, pages 973-990.
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Amy R Scholik, Ung-Soo Lee, Ching K Chow & Hong Y Yan. (2004) Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 137:4, pages 313-323.
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J. Schönleber & R.H. Anken. (2004) Efficacy of an ototoxic aminoglycoside (gentamicin) on the differentiation of the inner ear of cichlid fish. Advances in Space Research 33:8, pages 1416-1420.
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Leonard P. Rybak & Thomas Kelly. (2003) Ototoxicity: bioprotective mechanisms. Current Opinion in Otolaryngology & Head and Neck Surgery 11:5, pages 328-333.
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Bruno Sergi, Aldo Ferraresi, Diana Troiani, Gaetano Paludetti & Anna Rita Fetoni. (2003) Cisplatin ototoxicity in the guinea pig: vestibular and cochlear damage. Hearing Research 182:1-2, pages 56-64.
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