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Research Article

Cellular Immune Response of Adenoidal and Tonsillar Lymphocytes to the P6 Outer Membrane Protein of Non-typeable Haemophilus Influenzae and its Relation to Otitis Media

Pages 377-383 | Published online: 08 Jul 2009

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Jeremy S. Dyke, Maria Cristina Huertas-Diaz, Frank Michel, Nathan E. Holladay, Robert J. Hogan, Biao He & Eric R. Lafontaine. (2020) The Peptidoglycan-associated lipoprotein Pal contributes to the virulence of Burkholderia mallei and provides protection against lethal aerosol challenge. Virulence 11:1, pages 1024-1040.
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M. Nadeem Khan, Dabin Ren, Ravinder Kaur, Saleem Basha, Robert Zagursky & Michael E. Pichichero. (2016) Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae. Expert Review of Vaccines 15:7, pages 863-878.
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V. Tzenova, E. Stoykova, S. Lolov, T. Karchev & G. Stoilov. (2004) Quantitative Immunohistochemical Investigation of IgA1 and IgA2 in Nasopharyngeal and Palatine Tonsils. Biotechnology & Biotechnological Equipment 18:3, pages 149-155.
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Kalyan K. Dewan, Amanda Caulfield, Yang Su, Colleen J. Sedney, Maiya Callender, Jillian Masters, Uriel Blas-Machado & Eric T. Harvill. (2023) Adaptive immune protection of the middle ears differs from that of the respiratory tract. Frontiers in Cellular and Infection Microbiology 13.
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Michael W. Mather, Steven Powell, Benjamin Talks, Chris Ward, Colin D. Bingle, Muzlifah Haniffa & Jason Powell. (2021) Dysregulation of immune response in otitis media. Expert Reviews in Molecular Medicine 23.
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Jessica Jane Browne, Evan Howard Matthews, Andrew William Taylor-Robinson & Jennelle Maree Kyd. (2019) Regulatory T lymphocytes are associated with increased nasopharyngeal colonization in children. International Journal of Pediatric Otorhinolaryngology 120, pages 51-57.
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Elke Seppanen, Dino Tan, Karli J. Corscadden, Andrew J. Currie, Peter C. Richmond, Ruth B. Thornton & Lea-Ann S. Kirkham. (2018) Evidence of functional cell-mediated immune responses to nontypeable Haemophilus influenzae in otitis-prone children. PLOS ONE 13:4, pages e0193962.
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Margaretha L. Casselbrant & Ellen M. Mandel. 2015. Cummings Pediatric Otolaryngology. Cummings Pediatric Otolaryngology 209 227.e6 .
Helen M. Massa, David J. Lim, Yuichi Kurono & Allan W. Cripps. 2015. Mucosal Immunology. Mucosal Immunology 1923 1942 .
Sharad K. Sharma & Michael E. Pichichero. (2013) Cellular Immune Response in Young Children Accounts for Recurrent Acute Otitis Media. Current Allergy and Asthma Reports 13:5, pages 495-500.
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Sharad K. Sharma, Janet R. Casey & Michael E. Pichichero. (2011) Reduced Memory CD4+ T-Cell Generation in the Circulation of Young Children May Contribute to the Otitis-Prone Condition. The Journal of Infectious Diseases 204:4, pages 645-653.
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Margaretha L. Casselbrant & Ellen M. Mandel. 2010. Cummings Otolaryngology - Head and Neck Surgery. Cummings Otolaryngology - Head and Neck Surgery 2761 2777 .
Yoshiya Ishida, Yusuke Abe & Yasuaki Harabuchi. (2007) Effects of macrolides on antigen presentation and cytokine production by dendritic cells and T lymphocytes. International Journal of Pediatric Otorhinolaryngology 71:2, pages 297-305.
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Shyi-Jou Chen, Mong-Ling Chu, Chia-Jen Wang, Ching-Len Liao, Shie-Liang Hsieh, Huey-Kang Sytwu & Chih-Chien Wang. (2006) Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae . Clinical Science 111:4, pages 253-263.
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Yoshiya Ishida, Yusuke Abe, Mitsuru Yanai, Hiroya Kobayashi & Yasuaki Harabuchi. (2006) Identification of human T-cell epitopes and highly immunogenic analog peptides on the non-typeable Haemophilus influenzae P6 outer membrane protein. Clinical Immunology 121:1, pages 90-99.
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Timothy F. Murphy, Charmaine Kirkham & Alan J. Lesse. (2006) Construction of a Mutant and Characterization of the Role of the Vaccine Antigen P6 in Outer Membrane Integrity of Nontypeable Haemophilus influenzae . Infection and Immunity 74:9, pages 5169-5176.
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Michelle McMahon, Timothy F. Murphy, Jennelle Kyd & Yasmin Thanavala. (2005) Role of an immunodominant T cell epitope of the P6 protein of nontypeable Haemophilus influenzae in murine protective immunity. Vaccine 23:27, pages 3590-3596.
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Joel M. Bernstein, Espen S. Baekkevold & Per Brandtzaeg. 2005. Mucosal Immunology. Mucosal Immunology 1547 1572 .
Yoshiya Ishida, Yusuke Abe, Mitsuru Yanai & Yasuaki Harabuchi. (2003) Epitope analysis of the P6 outer membrane protein of non-typeable Haemophilus influenzae. International Congress Series 1257, pages 177-179.
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Victoria Davenport, Terry Guthrie, Jamie Findlow, Ray Borrow, Neil A. Williams & Robert S. Heyderman. (2003) Evidence for Naturally Acquired T Cell-Mediated Mucosal Immunity to Neisseria meningitidis   . The Journal of Immunology 171:8, pages 4263-4270.
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Małgorzata Kowalska, Halina Kowalska, Lidia Zawadzka-Głos, Małgorzata Dębska, Ewa Szerszeń, Mieczysław Chmielik & Maria Wąsik. (2003) Dysfunction of peripheral blood granulocyte oxidative metabolism in children with recurrent upper respiratory tract infections. International Journal of Pediatric Otorhinolaryngology 67:4, pages 365-371.
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M. J. Epton, B. J. Hales, P. J. Thompson & W. R. Thomas. (2002) T cell cytokine responses to outer membrane proteins of Haemophilus influenzae and the house dust mite allergens Der p 1 in allergic and non‐allergic subjects . Clinical & Experimental Allergy 32:11, pages 1589-1595.
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Yuji Yokoyama & Yasuaki Harabuchi. (2002) Decreased serum and pharyngeal antibody levels specific to streptococcal lipoteichoic acid in children with recurrent tonsillitis. International Journal of Pediatric Otorhinolaryngology 63:3, pages 199-207.
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Yusuke AbeTimothy F. MurphySanjay SethiHoward S. FadenJacek DmochowskiYasuaki HarabuchiYasmin M. Thanavala. (2002) Lymphocyte Proliferative Response to P6 of Haemophilus influenzae Is Associated with Relative Protection from Exacerbations of Chronic Obstructive Pulmonary Disease . American Journal of Respiratory and Critical Care Medicine 165:7, pages 967-971.
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M.aP. Prim Espada, J.I. De Diego Sastre, C. Alfonso Carrillo & N. Sastre Baticon. (2002) Factores predictivos de eficacia en las profilaxis antimicrobianas para la otitis media aguda de repetición. Anales de Pediatría 56:3, pages 204-207.
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Niels van Heerbeek, Ad F. M. Snik, Koen J. A. O. Ingels & Gerhard A. Zielhuis. (2016) Eustachian Tube Function in Children after Insertion of Ventilation Tubes. Annals of Otology, Rhinology & Laryngology 110:12, pages 1141-1146.
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Niels van Heerbeek, Koen J. A. O. Ingels, Ad F. M. Snik & Gerhard A. Zielhuis. (2001) Reliability of Manometric Eustachian Tube Function Tests in Children. Otology & Neurotology 22:2, pages 183-187.
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Jennelle M. Kyd, A.Ruth Foxwell & Allan W. Cripps. (2001) Mucosal immunity in the lung and upper airway. Vaccine 19:17-19, pages 2527-2533.
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