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Acta Oto-Laryngologica Volume 119, 1999 - Issue 1
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Research Article

Validation of Animal Experiments on Ciliary Function In Vitro. II. The Influence of Absorption Enhancers, Preservatives and Physiologic Saline

Wilbert M. Boek, Stefan G. Romeijn, Kees Graamans, J. Coos Verhoef, Frans W. H. M. Merkus, Egbert H. Huizing 1Department of Otorhinolaryngology
Pages 98-101 | Published online: 08 Jul 2009

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Ying Li, Xianpeng Fan, Wanqing Li, Peng Yang, Hui Zhang, Daoquan Tang, Xiaoxin Yin, Jianxu Sun & Aiping Zheng. (2018) Metoclopramide nasal spray in vitro evaluation and in vivo pharmacokinetic studies in dogs. Pharmaceutical Development and Technology 23:3, pages 275-281.
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Articles from other publishers (22)

Yuguang Fu, Jie Tong, Fandan Meng, Doris Hoeltig, Guangliang Liu, Xiangping Yin & Georg Herrler. (2018) Ciliostasis of airway epithelial cells facilitates influenza A virus infection. Veterinary Research 49:1.
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Neil F. Johnson. (2018) Pulmonary Toxicity of Benzalkonium Chloride. Journal of Aerosol Medicine and Pulmonary Drug Delivery 31:1, pages 1-17.
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Alan D. Workman & Noam A. Cohen. (2014) The Effect of Drugs and Other Compounds on the Ciliary Beat Frequency of Human Respiratory Epithelium. American Journal of Rhinology & Allergy 28:6, pages 454-464.
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Joke Lenoir, Claus Bachert, Jean-Paul Remon & Els Adriaens. (2013) The Slug Mucosal Irritation (SMI) assay: A tool for the evaluation of nasal discomfort. Toxicology in Vitro 27:6, pages 1954-1961.
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Svetlana Dimova, Frederik Maes, Marcus E Brewster, Mark Jorissen, Mark Noppe & Patrick Augustijns. (2005) High-speed digital imaging method for ciliary beat frequency measurement. Journal of Pharmacy and Pharmacology 57:4, pages 521-526.
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Thierry Pauloin, Mélody Dutot, Jean-Michel Warnet & Patrice Rat. (2008) In vitro modulation of preservative toxicity: High molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride. European Journal of Pharmaceutical Sciences 34:4-5, pages 263-273.
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A. Henning, M. Schneider, M. Bur, F. Blank, P. Gehr & C.-M. Lehr. (2008) Embryonic Chicken Trachea as a New In Vitro Model for the Investigation of Mucociliary Particle Clearance in the Airways. AAPS PharmSciTech 9:2, pages 521-527.
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Andreas Neher, Michaela Gstöttner, Michael Thaurer, Patrick Augustijns, Monika Reinelt & Wolfgang Schobersberger. (2008) Influence of Essential and Fatty Oils on Ciliary Beat Frequency of Human Nasal Epithelial Cells. American Journal of Rhinology 22:2, pages 130-134.
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R. Mallants, M. Jorissen & P. Augustijns. (2007) Effect of preservatives on ciliary beat frequency in human nasal epithelial cell culture: Single versus multiple exposure. International Journal of Pharmaceutics 338:1-2, pages 64-69.
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T. Deutschle, U. Porkert, R. Reiter, T. Keck & H. Riechelmann. (2006) In vitro genotoxicity and cytotoxicity of benzalkonium chloride. Toxicology in Vitro 20:8, pages 1472-1477.
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O. Michel, S. Essers, W.-J. Heppt, V. Johannssen, W. Reuter & G. Hommel. (2005) The value of Ems Mineral Salts in the treatment of rhinosinusitis in children. International Journal of Pediatric Otorhinolaryngology 69:10, pages 1359-1365.
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S. Dimova, V. Vlaeminck, M.E. Brewster, M. Noppe, M. Jorissen & P. Augustijns. (2005) Stable ciliary activity in human nasal epithelial cells grown in a perfusion system. International Journal of Pharmaceutics 292:1-2, pages 157-168.
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Norbert KlOucker, Peter Rudolph & Thomas Verse. (2018) Evaluation of Protective and Therapeutic Effects of Dexpanthenol on Nasal Decongestants and Preservatives: Results of Cytotoxic Studies in Vitro. American Journal of Rhinology 18:5, pages 315-320.
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Herbert Riechelmann, Tom Deutschle, Anja Stuhlmiller, Silke Gronau & Harald Bürner. (2018) Nasal Toxicity of Benzalkonium Chloride. American Journal of Rhinology 18:5, pages 291-299.
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T. Verse, N. Klöcker, F. Riedel, W. Pirsig & M. O. Scheithauer. (2004) Dexpanthenol—Nasenspray vs. NasensalbeDexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. HNO 52:7, pages 611-615.
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Norbert Klöcker, Axel Kramer, Thomas Verse, Claudia Sikora, Peter Rudolph & Georg Daeschlein. (2004) Antimicrobial safety of a preservative-free nasal multiple-dose drug administration system. European Journal of Pharmaceutics and Biopharmaceutics 57:3, pages 489-493.
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Erika Y. C. Viertler, José R. G. Testa, Plínio F. Morgado & Rimarcs G. Ferreira. (2003) Irrigação intranasal: avaliação dos efeitos do uso de soluções hidroeletrolíticas na mucosa de ratos. Revista Brasileira de Otorrinolaringologia 69:4, pages 491-495.
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Robert M. Naclerio, Fuad M. Baroody, Nalini Bidani, Tineo Marcy De & Bill C. Penney. (2016) A Comparison of Nasal Clearance after Treatment of Perennial Allergic Rhinitis with Budesonide and Mometasone. Otolaryngology–Head and Neck Surgery 128:2, pages 220-227.
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Stanley S Davis & Lisbeth Illum. (2003) Absorption Enhancers for Nasal Drug Delivery. Clinical Pharmacokinetics 42:13, pages 1107-1128.
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Wilbert M. Boek, Kees Graamans, Hanny Natzijl, Peter P. van Rijk & Egbert H. Huizing. (2002) Nasal Mucociliary Transport: New Evidence for a Key Role of Ciliary Beat Frequency. The Laryngoscope 112:3, pages 570-573.
Crossref
P. GRAF. (2001) Benzalkonium chloride as a preservative in nasal solutions: re-examining the data. Respiratory Medicine 95:9, pages 728-733.
Crossref
Paul Merkus, Stefan G. Romeijn, J. Coos Verhoef, Frans W. H. M. Merkus & Paul F. Schouwenburg. (2001) Classification of Cilio-Inhibiting Effects of Nasal Drugs. The Laryngoscope 111:4, pages 595-602.
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