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American Industrial Hygiene Association Journal Volume 38, 1977 - Issue 11
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Original Articles

Results of a two year chronic toxicity study with hexachlorobutadiene in rats

R.J. KQCIBA Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
D.G. KEYES Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
G.C. JERSEY Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
J.J. BALLARD Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
D.A. DITTENBER Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
J.F. QUAST Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
C.E. WADE Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
,
C.G. HUMISTON Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
&
B.A. SCHWETZ Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan 48640
 show all
Pages 589-602 | Published online: 04 Jun 2010

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Gordon C. Hard. (2018) Critical review of renal tubule karyomegaly in non-clinical safety evaluation studies and its significance for human risk assessment. Critical Reviews in Toxicology 48:7, pages 575-595.
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Mohammad Taher Bouroshaki, Hamid Reza Sadeghnia, Marjan Banihasan & Samaneh Yavari. (2010) Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys. Renal Failure 32:5, pages 612-617.
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Edward A. Lock & Gordon C. Hard. (2004) Chemically Induced Renal Tubule Tumors in the Laboratory Rat and Mouse: Review of the NCI/NTP Database and Categorization of Renal Carcinogens Based on Mechanistic Information. Critical Reviews in Toxicology 34:3, pages 211-299.
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K. Hughes, B. Idris & M. E. Meek. (2001) HEXACHLOROBUTADIENE: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS. Journal of Environmental Science and Health, Part C 19:1, pages 267-280.
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Wolfgang Dekant & Spiros Vamvakas. (1996) Biotransformation and Membrane Transport in Nephrotoxicity. Critical Reviews in Toxicology 26:3, pages 309-334.
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Gangadhar Choudhary. (1995) Human health perspectives on environmental exposure to hexachlorobutadiene: A review. Journal of Environmental Science and Health, Part C 13:2, pages 179-203.
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W. Dekant & S. Vamvakas. (1993) Glutathione-dependent bioactivation of xenobiotics. Xenobiotica 23:8, pages 873-887.
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M. Koob & W. Dekant. (1992) Biotransformation of the hexachlorobutadiene metabolites 1-(glutathion-S-yl)-pentachlorobutadiene and 1-(cystein-S-yl)-pentachlorobutadiene in the isolated perfused rat liver. Xenobiotica 22:1, pages 125-138.
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B. F. Trump, T. W. Jones, K. A. Elliget, M. W. Smith, P. C. Phelps, A. Maki & I. K. Berezesky. (1990) Relation Between Toxicity and Carcinogenesis in the Kidney: an Heuristic Hypothesis. Renal Failure 12:3, pages 183-191.
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Lora E. Rikans. (1989) Influence of Aging on Chemically Induced Hepato-Toxicity: Role of Age-Related Changes in Metabolism. Drug Metabolism Reviews 20:1, pages 87-110.
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Wolfgang Dekant, Spyridon Vamvakas & M. W. Anders. (1989) Bioactivation of Nephrotoxic Haloalkenes by Glutathione Conjugation: Formation of Toxic and Mutagenic Intermediates by Cysteine Conjugate β-Lyase. Drug Metabolism Reviews 20:1, pages 43-83.
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Edward A. Lock & William O. Berndt. (1988) Studies on the Mechanism of Nephrotoxicity and Nephrocarcinogenicity of Halogenated Alkenes. CRC Critical Reviews in Toxicology 19:1, pages 23-42.
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M. W. Anders, Lawrence Lash, Wolfgang Dekant, Adnan A. Elfarra, David R. Dohn & Donald J. Reed. (1988) Biosynthesis and biotransformation of glutathioneS-Conjugates to toxic metabolites. CRC Critical Reviews in Toxicology 18:4, pages 311-341.
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Wolfgang Dekant, Dieter Schrenk, Spyridon Vamvakas & Dietrich Henschler. (1988) Metabolism of hexachloro-1,3-butadiene in mice: in vivo and in vitro evidence for activation by glutathione conjugation. Xenobiotica 18:7, pages 803-816.
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Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
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DeborahR. Jaffe, ChristopherD. Hassall, Klaus Brendel & A. Jay Gandolfi. (1983) In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene. Journal of Toxicology and Environmental Health 11:4-6, pages 857-867.
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W. T. Stott & P. G. Watanabe. (1982) Differentiation of Genetic Versus Epigenetic Mechanisms of Toxicity and Its Application to Risk Assessment. Drug Metabolism Reviews 13:5, pages 853-873.
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Yaotian Wang, Haiyan Zhang, Xingwang Hou, Qing Zhang, Weifang Chen, Jianbo Shi & Guibin Jiang. (2021) Simultaneous determination of tetra-, penta- and hexachlorobutadienes in shellfish by gas chromatography-triple quadrupole mass spectrometry. Environmental Pollution 289, pages 117845.
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Haiyan Zhang, Yanting Shen, Wencong Liu, Zhiqiao He, Jianjie Fu, Zongwei Cai & Guibin Jiang. (2019) A review of sources, environmental occurrences and human exposure risks of hexachlorobutadiene and its association with some other chlorinated organics. Environmental Pollution 253, pages 831-840.
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