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American Industrial Hygiene Association Journal Volume 39, 1978 - Issue 7
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Original Articles

Hapten-specific respiratory hypersensitivity in guinea pigs

MERYL H. KAROL Department of Industrial Environmental Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
,
HOLLY H. IOSET Department of Industrial Environmental Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
,
E. JOAN RILEY Department of Industrial Environmental Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
&
YVES C. ALARIE Department of Industrial Environmental Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
Pages 546-556 | Published online: 04 Jun 2010

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Gabriele Sabbioni, John H. Lamb, Peter B. Farmer & Ovnair Sepai. (1997) Reactions of 4 methylphenyl isocyanate with amino acids. Biomarkers 2:4, pages 223-232.
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GaryM. Liss, WilliamE. Halperin & PhilipJ. Landrigan. (1986) Occupational Asthma in a Home Pieceworker. Archives of Environmental Health: An International Journal 41:6, pages 359-362.
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Meryl H. Karol & Jack H. Dean. (1986) Respiratory effects of inhaled isocyanates. CRC Critical Reviews in Toxicology 16:4, pages 349-379.
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King‐Lit Wong, MerylH. Karol & Yves Alarie. (1985) Use of repeated co2 challenges to evaluate the pulmonary performance of guinea pigs exposed to toluene diisocyanate. Journal of Toxicology and Environmental Health 15:1, pages 137-148.
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Articles from other publishers (46)

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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 44 .
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Marianne Möller, Dietrich Henschler & Gabriele Sabbioni. (2005) Synthesis and Spectroscopic Characterization of 4‐Chlorophenyl Isocyanate (= 1‐chloro‐4‐isocyanatobenzene) Adducts with Amino Acids as Potential Dosimeters for the Biomonitoring of Isocyanate Exposure. Helvetica Chimica Acta 81:5-8, pages 1254-1263.
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Michael S Werley, Heather Burleigh-Flayer, Everett A Mount & Lois A Kotkoskie. (1997) Respiratory sensitization to konjac flour in guinea pigs. Toxicology 124:2, pages 115-124.
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Michael S. Werley, Heather D. Burleigh-Flayer & Bryan Ballantyne. (2016) Respiratory Peripheral Sensory Irritation and Hypersensitivity Studies With Glutaraldehyde Vapor. Toxicology and Industrial Health 11:5, pages 489-501.
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X. Baur, W. Marek, J. Ammon, A. B. Czuppon, B. Marczynski, M. Raulf-Heimsoth, H. Roemmelt & G. Fruhmann. (1994) Respiratory and other hazards of isocyanates. International Archives of Occupational and Environmental Health 66:3, pages 141-152.
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J. Hilton, R.J. Dearman, D.A. Basketter & I. Kimber. (1994) Serological responses induced in mice by immunogenic proteins and by protein respiratory allergens. Toxicology Letters 73:1, pages 43-53.
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J.W. Coleman, M.R. Holliday, R.J. Dearman & I. Kimber. (1994) Cytokine-mast cell interactions: relevance to IgE-mediated chemical allergy. Toxicology 88:1-3, pages 225-235.
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M. R. Holliday, J. W. Coleman, R. J. Dearman & I. Kimber. (2006) Induction of mast cell sensitization by chemical allergens: A comparative study. Journal of Applied Toxicology 13:2, pages 137-142.
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R. J. Dearman, D. A. Basketter & I. Kimber. (2006) Variable effects of chemical allergens on serum ige concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers. Journal of Applied Toxicology 12:5, pages 317-323.
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Rebecca J. Dearman, Lesley M. Spence & Ian Kimber. (1992) Characterization of murine immune responses to allergenic diisocyanates. Toxicology and Applied Pharmacology 112:2, pages 190-197.
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Franzkarl Brochhagen, Elizabeth Parker Burrows, Heidelore Fiedler, J. Konietzko, Wayne R. Mitchell, K. Mross, W. Mücke, David L. Parmer & David H. RosenblattFranzkarl Brochhagen. 1991. Anthropogenic Compounds. Anthropogenic Compounds 1 95 .
Yves Alarie. (1990) Methods to evaluate the pulmonary toxicity of biological aerosols. Aerobiologia 6:2, pages 202-204.
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S. Kochman, S. Lefebvre, J. Bernard, A. Maujean, A. Cazabat, F. Lavaud & M. Manfait. (1990) Toluene diisocyanate-induced conformational changes of serum albumin: a study on repeated inhalations in guinea-pigs. Toxicology Letters 50:2-3, pages 165-171.
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Peter S. Thorne & Meryl H. Karol. (1989) Association of fever with late-onset pulmonary hypersensitivity responses in the guinea pig. Toxicology and Applied Pharmacology 100:2, pages 247-258.
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Meryl H. Karol, Julie A. Hillebrand & Peter S. Thorne. (1989) Characteristics of weekly pulmonary hypersensitivity responses elicited in the guinea pig by inhalation of ovalbumin aerosols. Toxicology and Applied Pharmacology 100:2, pages 234-246.
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Robert F. Gerlach, Michele A. Medinsky, Charles H. Hobbs, David E. Bice, William E. Bechtold, Yung‐Sung Cheng, Nancy A. Gillett, Linda S. Birnbaum & Joe L. Mauderly. (2006) Effect of four‐week repeated inhalation exposure to unconjugated azodicarbonamide on specific and non‐specific airway sensitivity of the guinea pig. Journal of Applied Toxicology 9:3, pages 145-153.
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Peter S. Thorne & Meryl H. Karol. (1988) Assessment of airway reactivity in guinea pigs: Comparison of methods employing whole body plethysmography. Toxicology 52:1-2, pages 141-163.
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P.A. Botham, P.M. Hext, N.J. Rattray, S.T. Walsh & D.R. Woodcock. (1988) Sensitisation of guinea pigs by inhalation exposure to low molecular weight chemicals. Toxicology Letters 41:2, pages 159-173.
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Jacques De Ceaurriz, Philippe Ducos, Jean-Claude Micillino, Rene Gaudin & Claude Cavelier. (1987) Guinea pig pulmonary response to sensitization by five preformed monoisocyanate-ovalbumin conjugates. Toxicology 43:1, pages 93-101.
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Peter S. Thorne, Julie Hillebrand, Cathleen Magreni, E.J. Riley & Meryl H. Karol. (1986) Experimental sensitization to subtilisin. Toxicology and Applied Pharmacology 86:1, pages 112-123.
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E. Grunewalder & M. H. Karol. (2007) Nitrocellulose‐Based RAST to Detect IgE Antibodies in Workers Hypersensitive to Diphenylmethane‐4,4′‐Diisocyanate. Allergy 41:3, pages 203-209.
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J. Wayne Streilein, Joan Stein-Streilein & Judith Head. 1986. The Reticuloendothelial System. The Reticuloendothelial System 37 93 .
Michiko TOMINAGA, Shigekatsu KOHNO, Ken-ichi TANAKA & Katsuya OHATA. (1985) Studies on Toluene Diisocyanate (TDI)-lnduced Delayed Type Hypersensitivity. Japanese Journal of Pharmacology 39:2, pages 163-164.
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K. C. CHANG & M. H. KAROL. (2006) Diphenylmethane diisocyanate (MDI)‐induced asthma: evaluation of the immunologic responses and application of an animal model of isocyanate sensitivity. Clinical & Experimental Allergy 14:4, pages 329-339.
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Judith Stadler & Meryl H. Karol. (1984) Experimental delayed hypersensitivity following inhalation of dicyclohexylmethane-4,4′-diisocyanate: A concentration-response relationship. Toxicology and Applied Pharmacology 74:2, pages 244-249.
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William E. Brown, A.Yousif Shamoo, Betty L. Hill & Meryl H. Karol. (1984) Immobilized cholinesterase to detect airborne concentrations of hexamethylene diisocyanate (HDI). Toxicology and Applied Pharmacology 73:1, pages 105-109.
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ROY PATTERSON, C. RAYMOND ZEISS & KATHLEEN E. HARRIS. (1984) 9 Immunological Studies in Experimental Animals of Occupational Chemical Allergens. Clinics in Immunology and Allergy 4:1, pages 159-172.
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L.S. Mullin, C.K. Wood & N.D. Krivanek. (1983) Guinea pig respiratory response to isocyanates. Toxicology and Applied Pharmacology 71:1, pages 113-122.
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K.L. Wong, M.F. Stock & Y.C. Alarie. (1983) Evaluation of the pulmonary toxicity of plasticized polyvinyl chloride thermal decomposition products in guinea pigs by repeated CO2 challenges. Toxicology and Applied Pharmacology 70:2, pages 236-248.
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Meryl H. Karol. (1983) Concentration-dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure. Toxicology and Applied Pharmacology 68:2, pages 229-241.
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I.Leonard Bernstein, Greta L. Splansky, S.Edith Chen & Allen Vinegar. (1982) The guinea pig model of diisocyanate sensitization. Journal of Allergy and Clinical Immunology 70:5, pages 393-398.
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S.Edith Chen & I.Leonard Bernstein. (1982) The guinea pig model of diisocyanate sensitization. Journal of Allergy and Clinical Immunology 70:5, pages 383-392.
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Judith Stadler & Meryl H. Karol. (1982) Experimental delayed-onset pulmonary sensitivity: Identification of retest reactions in the lung. Toxicology and Applied Pharmacology 65:2, pages 323-328.
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Meryl H. Karol & Cathleen Magreni. (1982) Extensive skin sensitization with minimal antibody production in guinea pigs as a result of exposure to dicyclohexylmethane-4,4′-diisocyanate. Toxicology and Applied Pharmacology 65:2, pages 291-301.
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J. Sykora, M. Karol, G. Keleti & D. Novak. (1982) Amoebae as sources of hypersensitivity pneumonitis. Environment International 8:1-6, pages 343-347.
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Meryl H. Karol, Judith Stadler, Dwight Underhill & Yves Alarie. (1981) Monitoring delayed-onset pulmonary hypersensitivity in guinea pigs. Toxicology and Applied Pharmacology 61:2, pages 277-285.
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A. Trevisan & G. Moro. (1981) Role of Acetylcholinesterase Inhibition in Toluene Diisocyanate (TDI) Induced Bronchoconstriction. International Archives of Occupational and Environmental Health 49:2, pages 129-135.
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M.H. Karol, B.A. Hauth, E.J. Riley & C.M. Magreni. (1981) Dermal contact with toluene diisocyanate (TDI) produces respiratory tract hypersensitivity in guinea pigs. Toxicology and Applied Pharmacology 58:2, pages 221-230.
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J. M. DANKS, O. CROMWELL, J. A. BUCKINGHAM, A. J. NEWMAN‐TAYLOR & R. J. DAVIES. (2006) Toluene‐diisocyanate induced asthma: evaluation of antibodies in the serum of affected workers against a tolyl mono‐isocyanate protein conjugate. Clinical & Experimental Allergy 11:2, pages 161-168.
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. (2006) BRITISH SOCIETY FOR ALLERGY AND CLINICAL IMMUNOLOGY. Clinical & Experimental Allergy 10:3, pages 345-351.
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Meryl H. Karol, Christine Dixon, Martin Brady & Yves Alarie. (1980) Immunologic sensitization and pulmonary hypersensitivity by repeated inhalation of aromatic isocyanates. Toxicology and Applied Pharmacology 53:2, pages 260-270.
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MERYL H. KAROL & YVES ALARIE. (2006) Antigens which detect IgE antibodies in workers sensitive to toluene diisocyanate. Clinical & Experimental Allergy 10:1, pages 101-109.
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Meryl H. Karol, Beth Ann Hauth & Yves Alarie. (1979) Pulmonary hypersensitivity to hexyl isocyanate-ovalbumin aerosol in guinea pigs. Toxicology and Applied Pharmacology 51:1, pages 73-80.
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G.K. Sangha & Y. Alarie. (1979) Sensory irritation by toluene diisocyanate in single and repeated exposures. Toxicology and Applied Pharmacology 50:3, pages 533-547.
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