727
Views
33
CrossRef citations to date
0
Altmetric
PHARMACEUTICAL ANALYSIS

A New HPLC Method for the Simultaneous Determination of Acetaminophen, Phenylephrine, Dextromethorphan and Chlorpheniramine in Pharmaceutical Formulations

Pages 965-976 | Received 05 Dec 2007, Accepted 05 Jan 2008, Published online: 05 Jun 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Articles from other publishers (32)

Edgar Nagles, Andy A. Cardenas‐Riojas, Fernando Anaya‐Roa, Luz Roldán‐Tello & John J. Hurtado. (2024) Amperometric Method for Detecting Paracetamol using a Carbon Paste Electrode Modified with Vanadium(V) Oxide. ChemistrySelect 9:6.
Crossref
Nandeesha IMBasappa C. YallurManjunatha D. Hadagali. (2022) Liquid Chromatographic Method Development and Validation for the Simultaneous Determination of Phenylephrine Hydrochloride, Paracetamol, Caffeine and Diphenhydramine Hydrochloride in Pure and Formulations. Research Journal of Pharmacy and Technology, pages 3993-3998.
Crossref
E. Murugan & A. Poongan. (2022) A new sensitive electrochemical sensor based on BiVO4/ZrO2@graphene modified GCE for concurrent sensing of acetaminophen, phenylephrine hydrochloride and cytosine in medications and human serum samples. Diamond and Related Materials 126, pages 109117.
Crossref
Emmanuel Orman, Anthony Assumang, James Oppong-Kyekyeku, Peter Jagri Onilimor, Paul Kweku Peprah, Joseph Kwasi Adu, Samuel Oppong Bekoe & Samuel Asare-Nkansah. (2022) Chromatographic method development for the simultaneous assay of pseudoephedrine hydrochloride and chlorphenamine maleate in oral dosage formulations. Scientific African 15, pages e01109.
Crossref
Yasaman Sefid-Sefidehkhan, Maryam Khoshkam & Mandana Amiri. (2021) Chemometrics-assisted electrochemical determination of dextromethorphan hydrobromide and phenylephrine hydrochloride by carbon paste electrode. Chemical Papers 75:12, pages 6565-6573.
Crossref
Ming Wei, Wenbo Lu, Guoqin Liu, Yimin Jiang, Xuebo Liu, Liwei Bai, Xiaowei Cao, Jianfeng Jia & Haishun Wu. (2021) Ni 2 P Nanosheets: A High Catalytic Activity Platform for Electrochemical Detection of Acetaminophen . Chinese Journal of Chemistry 39:7, pages 1849-1854.
Crossref
Mahdi Ebrahimi, Mahmoud Reza Sohrabi, Fereshteh Motiee & Mehran Davallo. (2021) Rapid simultaneous spectrophotometric determination of acetaminophen, phenylephrine, and guaifenesin in a cold syrup formulation based on continuous wavelet transform and first derivative transform methods. Optik 230, pages 166323.
Crossref
Sayyed Hossein Hashemi, Massoud Kaykhaii, Ahmad Jamali Keikha & Nasrin Naruie. (2020) Application of molecularly imprinted polymer pipette tip micro-solid phase extraction of nalidixic acid and acetaminophen from pills and seawater samples and their determination by spectrophotometry. Chemical Papers 74:11, pages 4009-4023.
Crossref
Phoebe Esinam Goku, Emmanuel Orman, Anna Naa Kwarley Quartey, Joseph Kwasi Adu & Reimmel Kwame Adosraku. (2020) A Simple RP-HPLC Method to Simultaneously Assay the Contents of Lamivudine, Tenofovir, and Nevirapine in Fixed Dose Combined Oral Antiviral Medicines. Journal of Chemistry 2020, pages 1-9.
Crossref
M.A.A. Ragab, F.A. El Yazbi, E.M. Hassan, E.F. Khamis & M.M.A. Hamdy. (2020) Green HPTLC and stability-indicating RP-HPLC for the assay of dextromethorphan hydrobromide and menthol in their lozenges. Annales Pharmaceutiques Françaises 78:5, pages 368-378.
Crossref
Amir Ali, Umar Farooq, Mahmood Ahmed, Muhammad Makshoof Athar, M. Salman, Saira Arif, Kashif Nadeem & Hassan Naz. (2020) Stability-indicating RP-HPLC assay for simultaneous determination of chlorpheniramine maleate and prednisolone in veterinary injection. Acta Chromatographica 32:2, pages 122-127.
Crossref
Abdollah Abdollahi-Aghdam, Mir Reza Majidi, Hadi Veladi & Yadollah Omidi. (2020) SU8/glass microchip capillary electrophoresis integrated with Pt electrodes for separation and simultaneous detection of phenylephrine and acetaminophen. BioImpacts 11:4, pages 263-269.
Crossref
A.J. Patel, N.K. Patel, A.J. Vyas, A.B. Patel & A.I. Patel. (2020) RP-UPLC Stability Indicating Assay Method for Simultaneous Estimation of Dextromethorphan Hydrobromide and Chlorpheniramine Maleate in Tablet Dosage Form. Asian Journal of Organic & Medicinal Chemistry 5:3, pages 192-196.
Crossref
Shahram Lotfi & Hojat Veisi. (2019) Pd nanoparticles decorated poly-methyldopa@GO/Fe3O4 nanocomposite modified glassy carbon electrode as a new electrochemical sensor for simultaneous determination of acetaminophen and phenylephrine. Materials Science and Engineering: C 105, pages 110112.
Crossref
Thirupathi Dongala, Naresh Kumar Katari, Ashok Kumar Palakurthi & Sreekantha B. Jonnalagadda. (2019) Development and validation of a generic RP‐HPLC PDA method for the simultaneous separation and quantification of active ingredients in cold and cough medicines. Biomedical Chromatography 33:11.
Crossref
Shirinaz I. Khan & Ramani V. Motghare. (2019) Electrochemical Determination of Chlorophenaramine Based on RTIL/CNT Composite Modified Glassy Carbon Electrode in Pharmaceutical Samples. Journal of The Electrochemical Society 166:13, pages B1202-B1208.
Crossref
Naser F. Al-Tannak, Sami Bawazeer & David G. Watson. (2018) Exploring the Effect of Buffer Strength on the Retention Time of Weak Acids, Neutral and Weak Bases in Hydrophilic Interaction Liquid Chromatography (HILIC) Mode. Current Analytical Chemistry 15:1, pages 34-46.
Crossref
Mirela Sarbu, Željka Vukelić, David E. Clemmer & Alina D. Zamfir. (2017) Electrospray ionization ion mobility mass spectrometry provides novel insights into the pattern and activity of fetal hippocampus gangliosides. Biochimie 139, pages 81-94.
Crossref
Nagaraj ShettiDeepti Nayak. (2017) Electrochemical detection of chlorpheniramine maleate in the presence of an anionic surfactant and its analytical applications. Canadian Journal of Chemistry 95:5, pages 553-559.
Crossref
Akwasi Acheampong, Wilfred Owusu Gyasi, Godfred Darko, Joseph Apau & Sylvester Addai-Arhin. (2016) Validated RP-HPLC method for simultaneous determination and quantification of chlorpheniramine maleate, paracetamol and caffeine in tablet formulation. SpringerPlus 5:1.
Crossref
Behzad Rezaei, Melody Hamedian Esfahani & Ali A. Ensafi. (2016) Modified Au Nanoparticles/Imprinted Sol-Gel/Multiwall Carbon Nanotubes Pencil Graphite Electrode as a Selective Electrochemical Sensor for Papaverine Determination. IEEE Sensors Journal 16:19, pages 7037-7044.
Crossref
Ali Mohamed Yehia & Hebatallah Mohamed Essam. (2016) Development and validation of a generic high‐performance liquid chromatography for the simultaneous separation and determination of six cough ingredients: Robustness study on core–shell particles. Journal of Separation Science 39:17, pages 3357-3367.
Crossref
Brahmam Kapalavavi, Yu Yang, Ronita Marple & Chris Gamsky. (2016) Separation and analysis of pharmaceuticals in cold drugs using green chromatography. Separation and Purification Technology 158, pages 308-312.
Crossref
Ali M. Yehia & Heba M. Mohamed. (2016) Chemometrics resolution and quantification power evaluation: Application on pharmaceutical quaternary mixture of Paracetamol, Guaifenesin, Phenylephrine and p-aminophenol. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 152, pages 491-500.
Crossref
Z. Pourghobadi & R. Pourghobadi. (2015) Electrochemical Behavior and Voltammetric Determination of Chlorpheniramine Maleate by Means of Multiwall Carbon Nanotubes-Modified Glassy Carbon Electrode. International Journal of Electrochemical Science 10:9, pages 7241-7250.
Crossref
Emad A. Khudaish, Mohammed Al-Hinaai, Salim Al-Harthy & Karthik Laxman. (2014) Electrochemical oxidation of chlorpheniramine at polytyramine film doped with ruthenium (II) complex: Measurement, kinetic and thermodynamic studies. Electrochimica Acta 135, pages 319-326.
Crossref
Prinesh N. Patel, Gananadhamu Samanthula, Vishalkumar Shrigod, Sudipkumar C. Modh & Jainishkumar R. Chaudhari. (2013) RP-HPLC Method for Determination of Several NSAIDs and Their Combination Drugs. Chromatography Research International 2013, pages 1-13.
Crossref
Arun Kumar Kaura, Vikas Gupta, Monika Kaura, G.S. Roy & Parveen Bansal. (2013) Spectrophotometric determination of Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride by “two wavelengths method”. Journal of Pharmacy Research 7:5, pages 404-408.
Crossref
Mohammad Mahdi Moein, Mehran Javanbakht & Behrouz Akbari-adergani. (2011) Molecularly imprinted polymer cartridges coupled on-line with high performance liquid chromatography for simple and rapid analysis of dextromethorphan in human plasma samples. Journal of Chromatography B 879:11-12, pages 777-782.
Crossref
Xia Li, Xiaoyu Xu, Dharmatov Rahula Albano & Tianyan You. (2011) Optimization using central composite design for antihistamines separation by nonaqueous capillary electrophoresis with electrochemical and electrochemiluminescence detections. The Analyst 136:24, pages 5294.
Crossref
Frank Gunzer, Andreas Ulrich & Wolfgang Baether. (2010) A novel non-radioactive electron source for ion mobility spectrometry. International Journal for Ion Mobility Spectrometry 13:1, pages 9-16.
Crossref
Roberto Fernández-Maestre & Herbert H. HillJr.Jr.. (2009) Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages. International Journal for Ion Mobility Spectrometry 12:3, pages 91-102.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.