Tina S. Skinner-Adams, Gillian M. Fisher, Andrew G. Riches, Oliver E. Hutt, Karen E. Jarvis, Tony Wilson, Mark von Itzstein, Pradeep Chopra, Yevgeniya Antonova-Koch, Stephan Meister, Elizabeth A. Winzeler, Mary Clarke, David A. Fidock, Jeremy N. Burrows, John H. Ryan & Katherine T. Andrews. (2019) Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. Communications Biology 2:1.
Crossref
Gerlinde F. Plöger, Bertil Abrahamsson, Rodrigo Cristofoletti, Dirk W. Groot, Peter Langguth, Mehul U. Mehta, Alan Parr, James E. Polli, Vinod P. Shah, Tomokazu Tajiri & Jennifer B. Dressman. (2018) Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride. Journal of Pharmaceutical Sciences 107:7, pages 1761-1772.
Crossref
Michael C.D. Fürst, Anna S. Pirzer & Markus R. Heinrich. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry
1
22
.
Hazem Elewa & Kyle John Wilby. (2017) A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications. European Journal of Drug Metabolism and Pharmacokinetics 42:5, pages 745-756.
Crossref
Rahul P. Bakshi & Theresa A. Shapiro. 2016. Antibiotic Pharmacodynamics. Antibiotic Pharmacodynamics
415
439
.
James S. McCarthy & Richard N. Price. 2015. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
495
509.e5
.
Minhajul Arfeen, Dhilon S. Patel, Sheenu Abbat, Nikhil Taxak & Prasad V. Bharatam. (2014) Importance of cytochromes in cyclization reactions: Quantum chemical study on a model reaction of proguanil to cycloguanil. Journal of Computational Chemistry 35:28, pages 2047-2055.
Crossref
Ajay Kumar, Deepika Paliwal, Deepika Saini, Aman Thakur, Shilpy Aggarwal & Dhirender Kaushik. (2014) A comprehensive review on synthetic approach for antimalarial agents. European Journal of Medicinal Chemistry 85, pages 147-178.
Crossref
Irwin W. Sherman. 2011. Magic Bullets to Conquer Malaria. Magic Bullets to Conquer Malaria
257
276
.
W M Watkins, J D Chulay, D G Sixsmith, H C Spencer & R E Howells. (1987) A preliminary pharmacokinetic study of the antimalarial drugs, proguanil and chlorproguanil. Journal of Pharmacy and Pharmacology 39:4, pages 261-265.
Crossref
THOMAS A. MOORE. 2010. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
631
668
.
Ashok Kumar, Kumkum Srivastava, S. Raja Kumar, S.K. Puri & Prem M.S. Chauhan. (2009) Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents. Bioorganic & Medicinal Chemistry Letters 19:24, pages 6996-6999.
Crossref
Ramatoulie E JanhaFatoumatta Sisay-JoofMajidah Hamid-AdiamohArchibald WorwuiHannah L ChapmanHyginus OparaSam DunyoPaul Milligan, Kirk Rockett, Peter Winstanley, Munir Pirmohamed, Ann K Miller, David J ConwayRobert T Walton. (2009)
Effects of genetic variation at the
CYP2C19
/
CYP2C9
locus on pharmacokinetics of chlorcycloguanil in adult Gambians
. Pharmacogenomics 10:9, pages 1423-1431.
Crossref
Damaris S. Diaz, Michael. P. Kozar, Kirsten S. Smith, Constance O. Asher, Jason C. Sousa, Guy A. Schiehser, David. P. Jacobus, Wilbur. K. Milhous, Donald. R. Skillman & Todd. W. Shearer. (2008) Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines. Drug Metabolism and Disposition 36:2, pages 380-385.
Crossref
Jian Guan, Xihong Wang, Kirsten Smith, Arba Ager, Montip Gettayacamin, Dennis E. Kyle, Wilbur K. Milhous, Michael P. Kozar, Alan J. Magill & Ai J. Lin. (2007) Malaria Causal Prophylactic Activity of Imidazolidinedione Derivatives. Journal of Medicinal Chemistry 50:24, pages 6226-6231.
Crossref
Delphine Lejeune, Isabelle Souletie, Sandrine Houzé, Thierry Le bricon, Jacques Le bras, Bernard Gourmel & Pascal Houzé. (2007) Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 43:3, pages 1106-1115.
Crossref
Sharon J. Gardiner & Evan J. Begg. (2006) Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice. Pharmacological Reviews 58:3, pages 521-590.
Crossref
Eunice Wambui Nduati & Edward Mberu Kamau. (2006) Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: A rational basis for combination therapy. Acta Tropica 97:3, pages 357-363.
Crossref
Nathalie L. Leveque, William N. Charman & Francis C.K. Chiu. (2006) Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography–mass spectrometry. Journal of Chromatography B 830:2, pages 314-321.
Crossref
Todd. W. Shearer, Michael. P. Kozar, Michael T. O'Neil, Philip L. Smith, Guy A. Schiehser, David. P. Jacobus, Damaris S. Diaz, Young-Sun Yang, Wilbur. K. Milhous & Donald. R. Skillman. (2005) In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines. Journal of Medicinal Chemistry 48:8, pages 2805-2813.
Crossref
Mita M. Thapar, Seema Gupta, Carl Spindler, Walther H. Wernsdorfer & Anders Björkman. (2003) Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene 97:3, pages 331-337.
Crossref
Donald J. AbrahamDee Ann Casteel. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
919
1031
.
Anina D. Murphy & Naomi Lang-Unnasch. (1999)
Alternative Oxidase Inhibitors Potentiate the Activity of Atovaquone against
Plasmodium falciparum
. Antimicrobial Agents and Chemotherapy 43:3, pages 651-654.
Crossref
David A. Fidock, Takashi Nomura & Thomas E. Wellems. (1998)
Cycloguanil and Its Parent Compound Proguanil Demonstrate Distinct Activities against
Plasmodium falciparum
Malaria Parasites Transformed with Human Dihydrofolate Reductase
. Molecular Pharmacology 54:6, pages 1140-1147.
Crossref
Y Bergqvist, L Funding, A Kaneko, B Krysén & T Leek. (1998) Improved method for the simultaneous determination of proguanil and its metabolites by high-performance liquid chromatography and solid-phase extraction of 100-μl capillary blood samples dried on sampling paper. Journal of Chromatography B: Biomedical Sciences and Applications 719:1-2, pages 141-149.
Crossref
David A. Fidock & Thomas E. Wellems. (1997) Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proceedings of the National Academy of Sciences 94:20, pages 10931-10936.
Crossref
Satyavan Sharma & Nitya Anand. 1997. Approaches to Design and Synthesis of Antiparasitic Drugs. Approaches to Design and Synthesis of Antiparasitic Drugs
439
454
.
J.A. Kolawole, A. Mustapha, I. Abdul-Aguye & N. Ochekpe. (1996) Effect of temperature on chlorproguanil and proguanil hydrochloride solutions: A chemical stability study. Journal of Pharmaceutical and Biomedical Analysis 14:6, pages 685-693.
Crossref
D M GakunjuE K MberuS F DossajiA I GrayR D WaighP G WatermanW M Watkins. (1995) Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy. Antimicrobial Agents and Chemotherapy 39:12, pages 2606-2609.
Crossref
Chohreh Partovian, Evelyne Jacqz-Aigrain, Annick Keundjian, Patrice Jaillon & Christian Funck-Brentano. (1995) Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans*. Clinical Pharmacology & Therapeutics 58:3, pages 257-263.
Crossref
P A WinstanleyE K MberuI S SzwandtA M BreckenridgeW M Watkins. (1995) In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrobial Agents and Chemotherapy 39:4, pages 948-952.
Crossref
R Setiabudy, M Kusaka, K Chiba, I Darmansjah & T Ishizaki. (2012) Metabolic disposition of proguanil in extensive and poor metabolisers of S‐mephenytoin 4'‐hydroxylation recruited from an Indonesian population.. British Journal of Clinical Pharmacology 39:3, pages 297-303.
Crossref
L K BascoO RamiliarisoaP RingwaldJ C DouryJ Le Bras. (1993) In vitro activity of cycloguanil against African isolates of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 37:4, pages 924-925.
Crossref
W.M. Watkins, E.K. Mberu, C.G. Nevill, S.A. Ward, A.M. Breckenridge & D.K. Koech. (1990) Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults. Transactions of the Royal Society of Tropical Medicine and Hygiene 84:4, pages 492-495.
Crossref
A.F. Cowman & S.J. Foote. (1990) Chemotherapy and drug resistance in malaria. International Journal for Parasitology 20:4, pages 503-513.
Crossref
Bjöhrn Eriksson, Marianne Lebbad & Anders Björkman. (1989) In vitro activity of proguanil, chlorproguanil and their main metabolites against Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene 83:4, pages 488.
Crossref
H.V. Scott, M.D. Edstein, J.R. Veenendaal & K.H. Rieckmann. (1988) A sensitive bioassay for serum cycloguanil using Plasmodium falciparumin vitro. International Journal for Parasitology 18:5, pages 605-609.
Crossref
William F. Mandell & Harold C. Neu. (1988) Parasitic Infections: Therapeutic Considerations. Medical Clinics of North America 72:3, pages 669-690.
Crossref
T.Venkata Ramanaiah & A. Gajanana. (1988) Superior antimalarial activity of proguanil to cycloguanil after in vitro bioconversion. Transactions of the Royal Society of Tropical Medicine and Hygiene 82:3, pages 358-359.
Crossref
Timothy G. Geary & James B. Jensen. 1986. Chemotherapy of Parasitic Diseases. Chemotherapy of Parasitic Diseases
87
114
.