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Annals of Tropical Medicine & Parasitology Volume 79, 1985 - Issue 3
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Original Articles

A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii

R. E. HowellsDepartments of Tropical Medicine and Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA
,
H. M. GillesDepartments of Tropical Medicine and Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA
&
N. S. BentDepartments of Tropical Medicine and Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA
Pages 247-251 | Received 17 Feb 1984, Published online: 15 Nov 2016

Citations (13)

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Read on this site (2)

Allan Schapira. (1990) The Resistance of Falciparum Malaria in Africa to 4-Aminoquinolines and Antifolates. Scandinavian Journal of Infectious Diseases 22:sup75, pages 1-64.
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E. Petersen, B. Hogh, A. P. Hanson, A. Bjorkman & H. Flacks. (1990) In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil. Annals of Tropical Medicine & Parasitology 84:6, pages 563-571.
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Articles from other publishers (11)

Tiago Rodrigues, Miguel Prudêncio, Rui Moreira, Maria M. Mota & Francisca Lopes. (2011) Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal. Journal of Medicinal Chemistry 55:3, pages 995-1012.
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A.E.T Yeo, M.D Edstein & K.H Rieckmann. (1997) Antimalarial activity of the triple combination of proguanil, atovaquone and dapsone. Acta Tropica 67:3, pages 207-214.
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E.K. Mberu, T. Wansor, H. Sato, Y. Nishikawa & W.M. Watkins. (1995) Japanese poor metabolizers of proguanil do not have an increased risk of malaria chemoprophylaxis breakthrough. Transactions of the Royal Society of Tropical Medicine and Hygiene 89:6, pages 658-659.
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Leonardo K. Basco, Pascal Ringwald, Rasoka Thor, Jean-Claude Doury & Jacques Le Bras. (1995) Activity in vitro of chloroquine, cycloguanil, and mefloquine against African isolates of Plasmodium falciparum: presumptive evidence for chemoprophylactic efficacy in Central and West Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 89:6, pages 657-658.
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L K BascoO RamiliarisoaP RingwaldJ C DouryJ Le Bras. (1993) In vitro activity of cycloguanil against African isolates of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 37:4, pages 924-925.
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Bjǒrn Eriksson, Beatrice Courtier, Anders Bjǒrkman, François Miltgen & Dominique Mazier. (1991) Activity of dihydrofolate reductase inhibitors on the hepatic stages of Plasmodium yoelii yoelii in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene 85:6, pages 725-726.
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W.M. Watkins, E.K. Mberu, C.G. Nevill, S.A. Ward, A.M. Breckenridge & D.K. Koech. (1990) Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults. Transactions of the Royal Society of Tropical Medicine and Hygiene 84:4, pages 492-495.
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T.Venkata Ramanaiah & A. Gajanana. (1988) Superior antimalarial activity of proguanil to cycloguanil after in vitro bioconversion. Transactions of the Royal Society of Tropical Medicine and Hygiene 82:3, pages 358-359.
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W.M. Watkins, A.J. Oloo, H.M. Gilles, A.D. Brandling-Bennett, R.E. Howells & D.K. Koech. (1987) INADEQUACY OF CHLORPROGUANIL 20 mg PER WEEK AS CHEMOPROPHYLAXIS FOR FALCIPARUM MALARIA IN KENYA. The Lancet 329:8525, pages 125-128.
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M.H. Coosemans, M. Barutwanayo, E. Onori, C. Otoul, B. Gryseels & M. Wéry. (1987) Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil. Transactions of the Royal Society of Tropical Medicine and Hygiene 81:1, pages 151-156.
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TimothyE.A. Peto & CharlesF. Gilks. (1986) STRATEGIES FOR THE PREVENTION OF MALARIA IN TRAVELLERS: COMPARISON OF DRUG REGIMENS BY MEANS OF RISK-BENEFIT ANALYSIS. The Lancet 327:8492, pages 1256-1261.
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