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Annals of Tropical Medicine & Parasitology Volume 89, 1995 - Issue 5
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Original Articles

Efficacy and tolerability of a sequential, artesunate suppository plus mefloquine, treatment of severe falciparum malaria

S. LooareesuwanDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Bangkok10400, Thailand
,
P. WilairatanaDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Bangkok10400, Thailand
,
S. VanijanontaDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Bangkok10400, Thailand
,
C. ViravanDepartment of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Bangkok10400, Thailand
&
M. AndrialMedical Department, Mepha Ltd., Aesch-Basel, Switzerland
Pages 469-475 | Received 28 Mar 1995, Accepted 16 May 1995, Published online: 15 Nov 2016

Citations (23)

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Laís Pessanha de Carvalho, Andrea Kreidenweiss & Jana Held. (2021) The preclinical discovery and development of rectal artesunate for the treatment of malaria in young children: a review of the evidence. Expert Opinion on Drug Discovery 16:1, pages 13-22.
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Alejandro Sosnik, Katia P Seremeta, Julieta C Imperiale & Diego A Chiappetta. (2012) Novel formulation and drug delivery strategies for the treatment of pediatric poverty-related diseases. Expert Opinion on Drug Delivery 9:3, pages 303-323.
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Gary H Posner. (1998) Antimalarial peroxides in the qinghaosu (artemisinin) and yingzhaosu families. Expert Opinion on Therapeutic Patents 8:11, pages 1487-1493.
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Peter Winstanley & Piero Olliaro. (1998) Clinical trials of chemotherapy for falciparum malaria. Expert Opinion on Investigational Drugs 7:2, pages 261-271.
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N. J. White. (1998) Why is it that antimalarial drug treatments do not always work?. Annals of Tropical Medicine & Parasitology 92:4, pages 449-458.
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P. Wilairatana, P. Viriyavejakul, S. Looareesuwan & T. Chongsuphajaisiddhi. (1997) Artesunate suppositories: an effective treatment for severe falciparum malaria in rural areas. Annals of Tropical Medicine & Parasitology 91:7, pages 891-896.
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Articles from other publishers (17)

Lorenz von Seidlein. (2023) The wrongful indictment of pre-referral rectal artesunate further delays the roll-out of this lifesaving drug. The Lancet Infectious Diseases 23:6, pages e208-e212.
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Christian Lengeler, Christian Burri, Phyllis Awor, Prosciova Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro, Antoinette Tshefu, Jean Okitawutshu, Jean-Claude Kalenga, Elizabeth Omoluabi, Babatunde Akano, Kazeem Ayodeji, Charles Okon, Ocheche Yusuf, Nina C. Brunner, Giulia Delvento, Tristan Lee, Mark Lambiris, Theodoor Visser, Harriet G. Napier, Justin M. Cohen, Valentina Buj, Aita Signorell & Manuel W. Hetzel. (2022) Community access to rectal artesunate for malaria (CARAMAL): A large-scale observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda. PLOS Global Public Health 2:9, pages e0000464.
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Wanida Mala, Polrat Wilairatana, Chutharat Samerjai, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui & Manas Kotepui. (2022) Prevalence of Signs of Severity Identified in the Thai Population with Malaria: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health 19:3, pages 1196.
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Thomas Zoller, Thomas Junghanss, Annette Kapaun, Ida Gjørup, Joachim Richter, Mats Hugo-Persson, Kristine Mørch, Behruz Foroutan, Norbert Suttorp, Salih Yürek & Holger Flick. (2011) Intravenous Artesunate for Severe Malaria in Travelers, Europe. Emerging Infectious Diseases 17:5, pages 771-777.
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Melba Gomes, Isabela Ribeiro, Marian Warsame, Harin Karunajeewa & Max Petzold. (2008) Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies. BMC Infectious Diseases 8:1.
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Harin A. Karunajeewa, Kenneth F. Ilett, Kitiya Dufall, Adedayo Kemiki, Moses Bockarie, Michael P. Alpers, P. Hugh Barrett, Paolo Vicini & Timothy M. E. Davis. (2004) Disposition of Artesunate and Dihydroartemisinin after Administration of Artesunate Suppositories in Children from Papua New Guinea with Uncomplicated Malaria. Antimicrobial Agents and Chemotherapy 48:8, pages 2966-2972.
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KI Barnes, J Mwenechanya, M Tembo, H Mcllleron, PI Folb, I Ribeiro, F Little, M Gomes & ME Molyneux. (2004) Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: a randomised study. The Lancet 363:9421, pages 1598-1605.
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HARIN A. KARUNAJEEWA, ADEDAYO KEMIKI, MICHAEL P. ALPERS, KERRY LORRY, KEVIN T. BATTY, KENNETH F. ILETT & TIMOTHY M. E. DAVIS. (2003) Safety and therapeutic efficacy of artesunate suppositories for treatment of malaria in children in Papua New Guinea. Pediatric Infectious Disease Journal 22:3, pages 251-255.
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Polrat Wilairatana, Srivicha Krudsood, Sombat Treeprasertsuk, Kobsiri Chalermrut & Sornchai Looareesuwan. (2002) The Future Outlook of Antimalarial Drugs and Recent Work on the Treatment of Malaria. Archives of Medical Research 33:4, pages 416-421.
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Udomsak SilachamroonSrivicha KrudsoodNanthaphorn PhophakSornchai Looareesuwan. (2002) Management of malaria in Thailand. The Korean Journal of Parasitology 40:1, pages 1.
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Maria das Graças Costa Alecrim, Luis Magalhães Carvalho, Marcus Cardoso Fernandes, Solange Dourado de Andrade, Adalgisa Cardoso Loureiro, Ana Ruth Lima Arcanjo & Wilson Duarte Alecrim. (2000) Tratamento da malária com artesunate (retocaps®) em crianças da Amazônia brasileira. Revista da Sociedade Brasileira de Medicina Tropical 33:2, pages 163-168.
Crossref
World Health Organization. (2000) Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 94, pages 1-90.
Crossref
C. Camus. (1999) Prise en charge thérapeutique d'une forme grave de paludisme à Plasmodium falciparum chez l'adulte. Médecine et Maladies Infectieuses 29, pages S164-S177.
Crossref
Isabela Ribeiro, Charles Woodrow & Sanjeev Krishna. 1999. 302 316 .
Richard Koopmans, Dao Dinh Duc, Piet A. Kager, Nguyen Xuan Khanh, Tran Khac Dien, Peter J. de Vries & Chris J. van Boxtel. (1998) The pharmacokinetics of artemisinin suppositories in Vietnamese patients with malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 92:4, pages 434-436.
Crossref
Michael Ashton, Nguyen Duy Sy, Nguyen Van Huong, Toufigh Gordi, Trinh Ngoc Hai, Dinh Xuan Huong, Nguyen Thi Niêu & Le Dinh Công. (1998) Artemisinin kinetics and dynamics during oral and rectal treatment of uncomplicated malaria*. Clinical Pharmacology & Therapeutics 63:4, pages 482-493.
Crossref
W. Peters. 1998. Advances in Parasitology Volume 41. Advances in Parasitology Volume 41 1 62 .

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