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Annals of Tropical Medicine & Parasitology Volume 94, 2000 - Issue 8
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Original Articles

Antibiotics and Wolbachia in filarial nematodes: antifilarial activity of rifampicin, oxytetracycline and chloramphenicol against Onchocerca gutturosa, Onchocerca lienalis and Brugia pahangi

S. TownsonTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, HarrowHA1 3UJ, U.K.Correspondence[email protected]
,
D. HuttonTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, HarrowHA1 3UJ, U.K.
,
J. SiemienskaTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, HarrowHA1 3UJ, U.K.
,
L. HollickTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, HarrowHA1 3UJ, U.K.
,
T. ScanlonTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, HarrowHA1 3UJ, U.K.
,
S. K. TagbotoTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, HarrowHA1 3UJ, U.K.
&
M. J. TaylorLiverpool School for Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
 show all
Pages 801-816 | Received 02 Aug 2000, Accepted 04 Oct 2000, Published online: 15 Nov 2016

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Simon Townson, Bernadette Ramirez, Foluke Fakorede, Marie-Annick Mouries & Solomon Nwaka. (2007) Challenges in drug discovery for novel antifilarials. Expert Opinion on Drug Discovery 2:sup1, pages S63-S73.
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B. Nyasse, I. Ngantchou, J.-J. Nono & B. Schneider. (2006) Antifilarial activity in vitro of polycarpol and 3-O-acetyl aleuritolic acid from cameroonian medicinal plants against Onchocerca gutturosa . Natural Product Research 20:4, pages 391-397.
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Articles from other publishers (39)

John Wilson McCall, Abdelmoneim Mansour, Utami DiCosty, Crystal Fricks, Scott McCall, Michael Timothy Dzimianski & Ben Carson. (2023) Long-term evaluation of viability of microfilariae and intravenously transplanted adult Dirofilaria immitis in microfilaremic dogs treated with low-dose, short- and long-treatment regimens of doxycycline and ivermectin. Parasites & Vectors 16:1.
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Fatima Amponsah Fordjour & Alexander Kwarteng. (2022) The filarial and the antibiotics: Single or combination therapy using antibiotics for filariasis. Frontiers in Cellular and Infection Microbiology 12.
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Marc P. Hübner, Kenneth Pfarr & Achim Hoerauf. 2022. Human and Animal Filariases. Human and Animal Filariases 589 614 .
Senyo Tagboto & Verner Orish. (2022) Drug development for onchocerciasis-the past, the present and the future. Frontiers in Tropical Diseases 3.
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Amy E. Marriott, Julio Furlong Silva, Nicolas Pionnier, Hanna Sjoberg, John Archer, Andrew Steven, Dale Kempf, Mark J. Taylor & Joseph D. Turner. (2022) A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult Brugia malayi. PLOS Neglected Tropical Diseases 16:6, pages e0010474.
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Fabian Audu Ugbe, Gideon Adamu Shallangwa, Adamu Uzairu & Ibrahim Abdulkadir. (2022) Theoretical modeling and design of some pyrazolopyrimidine derivatives as Wolbachia inhibitors, targeting lymphatic filariasis and onchocerciasis. In Silico Pharmacology 10:1.
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Mamta Gangwar, Ruchi Jha, Manish Goyal & Mrigank Srivastava. (2021) Biochemical characterization of Recombinase A from Wolbachia endosymbiont of filarial nematode Brugia malayi (wBmRecA). International Journal for Parasitology 51:10, pages 841-853.
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Natalie A. Hawryluk. (2020) Macrofilaricides: An Unmet Medical Need for Filarial Diseases. ACS Infectious Diseases 6:4, pages 662-671.
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Zhengren Xu, Shi-Ming Fang, Malina A. Bakowski, Mostafa E. Rateb, Dong Yang, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Mitchell V. Hull, Case W. McNamara & Ben Shen. (2019) Discovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686 . ACS Chemical Biology 14:6, pages 1174-1182.
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Qi Zhang, Dong Zhu, Jing Ding, Shuyidan Zhou, Liwei Sun & Haifeng Qian. (2019) Species-specific response of the soil collembolan gut microbiome and resistome to soil oxytetracycline pollution. Science of The Total Environment 668, pages 1183-1190.
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WanAliaa Wan Sulaiman, Joseph Kamtchum-Tatuene, MohdHazmi Mohamed, Vasudevan Ramachandran, SiewMooi Ching, SazlynaMohd Sazlly Lim, HasnurZaman Hashim, LiyanaNajwa Inche Mat, FanKee Hoo & Hamidon Basri. (2019) Anti-Wolbachia therapy for onchocerciasis & lymphatic filariasis: Current perspectives. Indian Journal of Medical Research 149:6, pages 706.
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Mamta Gangwar, Ruchi Jha, Manish Goyal & Mrigank Srivastava. (2019) Immunogenicity and protective efficacy of Recombinase A from Wolbachia endosymbiont of filarial nematode Brugia malayi (wBmRecA). Vaccine 37:4, pages 571-580.
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Sabine Specht, Kenneth M. Pfarr, Sandra Arriens, Marc P. Hübner, Ute Klarmann-Schulz, Marianne Koschel, Sonja Sternberg, Coralie Martin, Louise Ford, Mark J. Taylor & Achim Hoerauf. (2018) Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model. PLOS Neglected Tropical Diseases 12:1, pages e0006116.
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Joseph D. Turner, Raman SharmaGhaith Al JayoussiHayley E. TyrerJoanne GambleLaura HaywardRichard S. PriestleyEmma A. MurphyJill DaviesDavid WaterhouseDarren A. N. CookRachel H. ClareAndrew CassidyAndrew StevenKelly L. JohnstonJohn McCall, Louise FordJanet HemingwayStephen A. WardMark J. Taylor. (2017) Albendazole and antibiotics synergize to deliver short-course anti- Wolbachia curative treatments in preclinical models of filariasis . Proceedings of the National Academy of Sciences 114:45.
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Emilie Lefoulon, Alessio Giannelli, Benjamin L. Makepeace, Yasen Mutafchiev, Simon Townson, Shigehiko Uni, Guilherme G. Verocai, Domenico Otranto & Coralie Martin. (2017) Whence river blindness? The domestication of mammals and host-parasite co-evolution in the nematode genus Onchocerca. International Journal for Parasitology 47:8, pages 457-470.
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Maha M. A. Basyoni & Enas M. A. Rizk. (2016) Nematodes ultrastructure: complex systems and processes. Journal of Parasitic Diseases 40:4, pages 1130-1140.
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Richard Idro, Bernard Opar, Joseph Wamala, Catherine Abbo, Sylvester Onzivua, Deogratius Amos Mwaka, Angelina Kakooza-Mwesige, Anthony Mbonye & Jane R. Aceng. (2016) Is nodding syndrome an Onchocerca volvulus-induced neuroinflammatory disorder? Uganda's story of research in understanding the disease. International Journal of Infectious Diseases 45, pages 112-117.
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Ramaswamy Kalyanasundaram. 2018. Communicable Diseases of the Developing World. Communicable Diseases of the Developing World 97 124 .
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Elena Melnikow, Shulin Xu, Jing Liu, Aaron J. Bell, Elodie Ghedin, Thomas R. Unnasch & Sara Lustigman. (2013) A Potential Role for the Interaction of Wolbachia Surface Proteins with the Brugia malayi Glycolytic Enzymes and Cytoskeleton in Maintenance of Endosymbiosis. PLoS Neglected Tropical Diseases 7:4, pages e2151.
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Jeetendra Kumar Nag, Nidhi Shrivastava, Jyoti Gupta & Shailja Misra-Bhattacharya. (2013) Recombinant translation initiation factor-1 of Wolbachia is an immunogenic excretory secretory protein that elicits Th2 mediated immune protection against Brugia malayi. Comparative Immunology, Microbiology and Infectious Diseases 36:1, pages 25-38.
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Frederic Landmann, Denis Voronin, William Sullivan & Mark J. Taylor. (2011) Anti-filarial Activity of Antibiotic Therapy Is Due to Extensive Apoptosis after Wolbachia Depletion from Filarial Nematodes. PLoS Pathogens 7:11, pages e1002351.
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Francesca Tamarozzi, Alice Halliday, Katrin Gentil, Achim Hoerauf, Eric Pearlman & Mark J. Taylor. (2011) Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and Treatment. Clinical Microbiology Reviews 24:3, pages 459-468.
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S. Specht & S. Wanji. (2009) New insights into the biology of filarial infections. Journal of Helminthology 83:2, pages 199-202.
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Achim Hoerauf. (2008) Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis. Current Opinion in Infectious Diseases 21:6, pages 673-681.
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Shilpy Shakya, Preeti Bajpai, Sharad Sharma & Shailja Misra-Bhattacharya. (2008) Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi. Parasitology Research 102:5, pages 963-972.
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A. G. Hise, I. Gillette-Ferguson & E. Pearlman. (2004) The role of endosymbiotic Wolbachia bacteria in filarial disease . Cellular Microbiology 6:2, pages 97-104.
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Amy G. Hise, Illona Gillette-Ferguson & Eric Pearlman. (2016) Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria. Journal of Endotoxin Research 9:6, pages 390-394.
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Achim Hoerauf, Sabine Mand, Lars Volkmann, Marcelle Büttner, Yeboah Marfo-Debrekyei, Mark Taylor, Ohene Adjei & Dietrich W Büttner. (2003) Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Microbes and Infection 5:4, pages 261-273.
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R. Rao & Gary J. Weil. (2002) IN VITRO EFFECTS OF ANTIBIOTICS ON BRUGIA MALAYI WORM SURVIVAL AND REPRODUCTION. Journal of Parasitology 88:3, pages 605-611.
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S.A. Williams & S.J. Laney. 2002. The Filaria. The Filaria 31 42 .
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