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Original Articles

Airborne Chemical Irritants

Role of the Trigeminal Nerve

, &
Pages 37-42 | Received 29 Mar 1971, Accepted 29 Jul 1971, Published online: 22 Apr 2013

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Matthew J. Eden, Yasmeen M. Farra, Jacqueline Matz, Chiara Bellini & Jessica M. Oakes. (2022) Pharmacological and physiological response in Apoe−/− mice exposed to cigarette smoke or e-cigarette aerosols. Inhalation Toxicology 34:9-10, pages 260-274.
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Gunnar Damgård Nielsen. (1991) Mechanisms of Activation of the Sensory Irritant Receptor by Airborne Chemicals. Critical Reviews in Toxicology 21:3, pages 183-208.
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Craig S. Barrow, Yves Alarie & Maryanne F. Stock. (1978) Sensory Irritation and Incapacitation Evoked by Thermal Decomposition Products of Polymers and Comparisons with Known Sensory Irritants. Archives of Environmental Health: An International Journal 33:2, pages 79-88.
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Craig S. Barrow, Yves Alarie, James C. Warrick & Mary Anne F. Stock. (1977) Comparison of the Sensory Irritation Response in Mice to Chlorine and Hydrogen Chloride. Archives of Environmental Health: An International Journal 32:2, pages 68-76.
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Thomas J. Kulle & Gary P. Cooper. (1975) Effects of Formaldehyde and Ozone on the Trigeminal Nasal Sensory System. Archives of Environmental Health: An International Journal 30:5, pages 237-243.
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Yves Alarie. (1973) Sensory Irritation by Airborne Chemicals. CRC Critical Reviews in Toxicology 2:3, pages 299-363.
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Articles from other publishers (31)

Dennis Shusterman. (2023) Trigeminal Function in Sino-Nasal Health and Disease. Biomedicines 11:7, pages 1778.
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Keiichi Inui, ChangPing Chen, Jordan L. Pauli, Chiharu Kuroki, Shogo Tashiro, Yuichi Kanmura, Hideki Kashiwadani & Tomoyuki Kuwaki. (2016) Nasal TRPA1 mediates irritant‐induced bradypnea in mice. Physiological Reports 4:24.
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J. Enrique Cometto‐Muñiz & Christopher Simons. 2015. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation 1089 1112 .
Bryan Ballantyne. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Mehdi S. Hazari, William H. Rowan, Darrell W. Winsett, Allen D. Ledbetter, Najwa Haykal-Coates, William P. Watkinson & Daniel L. Costa. (2008) Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1. Respiratory Physiology & Neurobiology 160:2, pages 160-171.
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Bryan Ballantyne. 2005. Inhalation Toxicology, Second Edition. Inhalation Toxicology, Second Edition 269 306 .
William J. Mautz. (2003) Exercising animal models in inhalation toxicology: interactions with ozone and formaldehyde. Environmental Research 92:1, pages 14-26.
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Takashi Nishino. (2000) Physiological and Pathophysiological Implications of Upper Airway Reflexes in Humans.. The Japanese Journal of Physiology 50:1, pages 3-14.
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John B. Morris, John Stanek & Gerald Gianutsos. (1999) Sensory nerve-mediated immediate nasal responses to inspired acrolein. Journal of Applied Physiology 87:5, pages 1877-1886.
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Paul F. McCulloch, Kevin M. Faber & W.Michael Panneton. (1999) Electrical stimulation of the anterior ethmoidal nerve produces the diving response. Brain Research 830:1, pages 24-31.
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Dean M. Clerico. 1996. Diseases of the Sinuses. Diseases of the Sinuses 403 423 .
Michael S. Werley, Heather D. Burleigh-Flayer & Bryan Ballantyne. (2016) Respiratory Peripheral Sensory Irritation and Hypersensitivity Studies With Glutaraldehyde Vapor. Toxicology and Industrial Health 11:5, pages 489-501.
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Lea Frimann Hansen & Gunnar Damgård Nielsen. (2009) Sensory Irritation Effects of n‐Propanol and Ethylbenzene after Pretreatment with Capsaicin or Indomethacin. Pharmacology & Toxicology 75:3-4, pages 154-161.
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Fabrice Wallois & Jean-Michel Macron. (1994) Nasal air puff stimulations and laryngeal, thoracic and abdominal muscle activities. Respiration Physiology 97:1, pages 47-62.
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Lea Frimann Hansen, Maria Hammer, Susanna Heissel Petersen & Gunnar Damgård Nielsen. (1994) Effects of intranasal ZnSO4 irrigation on olfactory and trigeminal cues. Physiology & Behavior 55:4, pages 699-704.
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A. Inokuchi, C. P. Kimmelman & J. B. SnowJrJr. (1993) Convergence of olfactory and nasotrigeminal inputs and possible trigeminal contributions to olfactory responses in the rat thalamus. European Archives of Oto-Rhino-Laryngology 249:8, pages 473-477.
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GUNNAR DAMGÅRD NIELSEN & YVES ALARIE. (2006) Animal Assays for Upper Airway Irritation: Screening of Materials and Structure‐Activity Relations. Annals of the New York Academy of Sciences 641:1, pages 164-175.
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WAYNE L. SILVER. (2006) Neural and Pharmacological Basis for Nasal Irritation. Annals of the New York Academy of Sciences 641:1, pages 152-163.
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J. G. Widdicombe & G. Sant’Ambrogio. 1992. Comparative Aspects of Mechanoreceptor Systems. Comparative Aspects of Mechanoreceptor Systems 111 135 .
Gerald C. Clark. (1989) Comparison of the inhalation toxicity of kretek (clove cigarette) smoke with that of American cigarette smoke. I. One day exposure. Archives of Toxicology 63:1, pages 1-6.
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Uffe Kristiansen, Anne Marie Vinggaard & Gunnar Damg�rd Nielsen. (1988) The effects of n-butanol vapour on respiratory rate and tidal volume. Archives of Toxicology 61:3, pages 229-236.
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C. Babiuk, W.H. Steinhagen & C.S. Barrow. (1985) Sensory irritation response to inhaled aldehydes after formaldehyde pretreatment. Toxicology and Applied Pharmacology 79:1, pages 143-149.
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Tsubone Hirokazu, Oda Hajime, Akira K. Suzuki & Kubota Kentaro. (1982) Electrocardiographic abnormalities in rats by acute exposure to nitrogen dioxide. Toxicology Letters 12:2-3, pages 125-129.
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Wayne L. Silver & David G. Moulton. (1982) Chemosensitivity of rat nasal trigeminal receptors. Physiology & Behavior 28:5, pages 927-931.
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E.H. Silver, D.E. Leith & S.D. Murphy. (1981) Potentiation by triorthotolyl phosphate of acrylate ester-induced alterations in respiration. Toxicology 22:3, pages 193-203.
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D. G. Farrar & W. A. Galster. (2004) Biological end‐points for the assessment of the toxicity of the products of combustion of materials. Fire and Materials 4:1, pages 50-58.
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David J.K. Balfour. (1978) Studies on the uptake and metabolism of dibenz(b,f)-1,4-oxazepine (CR) by guinea-pig cornea. Toxicology 9:1-2, pages 11-20.
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Richard L. Doty, William E. Brugger, Peter C. Jurs, Michael A. Orndorff, Peter J. Snyder & L.Dale Lowry. (1978) Intranasal trigeminal stimulation from odorous volatiles: Psychometric responses from anosmic and normal humans. Physiology & Behavior 20:2, pages 175-185.
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A. Weber-Tschopp, T. Fischer, R. Gierer & E. Grandjean. (1977) Experimentelle reizwirkungen von akrolein auf den menschenExperimentally induced irritating effects of acrolein on men. International Archives of Occupational and Environmental Health 40:2, pages 117-130.
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R.W. Beuerman. (1975) Neurons in trigeminal nucleus and reticular formation excited by ethmoidal nerve stimulation. Brain Research 92:3, pages 479-484.
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Yves Alarie. (1973) Sensory irritation of the upper airways by airborne chemicals. Toxicology and Applied Pharmacology 24:2, pages 279-297.
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