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Original Articles

Early Response of Lungs to Low Levels of Nitrogen Dioxide

Light and Electron Microscopy

, &
Pages 160-179 | Received 29 Mar 1971, Accepted 31 Aug 1971, Published online: 22 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (33)

Carl J. Johnston, Gunter Oberdorster, Robert Gelein, Jacob N. Finkelstein. (2000) NEWBORN MICE DIFFER FROM ADULT MICE IN CHEMOKINE AND CYTOKINE EXPRESSION TO OZONE, BUT NOT TO ENDOTOXIN. Inhalation Toxicology 12:3, pages 205-224.
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Shiaw-Fen Ferng, C. Elizabeth Castro, AbdelmonemA. Afifi, Eliezer Bermudez & MohammadG. Mustafa. (1997) OZONE-INDUCED DNA STRAND BREAKS IN GUINEA PIG TRACHEOBRONCHIAL EPITHELIAL CELLS. Journal of Toxicology and Environmental Health 51:4, pages 353-367.
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Timothy E. Albertson, William F. Walby, Roblee P. Allen & R. Steven Tharratt. (1995) The Pharmacology and Toxicology of Three New Biologic Agents Used in Pulmonary Medicine. Journal of Toxicology: Clinical Toxicology 33:5, pages 427-438.
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Kiyomi Kikugawa, Kazuyuki Hiramoto, Yutaka Okamoto & Yo-Ko Hasegawa. (1994) Enhancement of Nitrogen Dioxide-Induced Lipid Peroxidation and Dna Strand Breaking by Cysteine and Glutathione. Free Radical Research 21:6, pages 399-408.
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Gerhard Polzer, Ines Lind, Evelyn Krüger & Arnulf Seidel. (1994) In Vitro Effects of Nitrogen Dioxide on the Release of Superoxide Anions, Tnf-α, and IL-8 by HL60-Macrophages and Bovine Alveolar Macrophages. Inhalation Toxicology 6:4, pages 359-377.
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Kazuhito Maejima, Tadao Suzuki, Hiroaki Numata, Akihiko Maekawa, Sumi Nagase & Noburu Ishinishi. (1993) Recovery from changes in the blood and nasal cavity and/or lungs of rats caused by exposure to methanol‐fueled engine exhaust. Journal of Toxicology and Environmental Health 39:3, pages 323-340.
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Kazuhito Maejima, Tadao Suzuki, Kanae Niwa, Hiroaki Numata, Akihiko Maekawa, Sumi Nagase & Noburu Ishinishi. (1992) Toxicity to rats of methanol‐fueled engine exhaust inhaled continuously for 28 days. Journal of Toxicology and Environmental Health 37:2, pages 293-312.
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Katsumi Mochitate, Kunihiko Ishida, Takumi Ohsumi & Takashi Miura. (1992) Long‐term effects of ozone and nitrogen dioxide on the metabolism and population of alveolar macrophages. Journal of Toxicology and Environmental Health 35:4, pages 247-260.
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Ronald E. Rasmussen. (1992) Effects of Acute no, Exposure in the Weanling Ferret Lung. Inhalation Toxicology 4:4, pages 373-382.
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Vahid Mohsenin. (1987) Airway responses to nitrogen dioxide in asthmatic subjects. Journal of Toxicology and Environmental Health 22:4, pages 371-380.
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RichardB. Schlesinger. (1987) Intermittent inhalation of nitrogen dioxide: Effects on rabbit alveolar macrophages. Journal of Toxicology and Environmental Health 21:1-2, pages 127-139.
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ThomasA. Vollmuth, KevinE. Driscoll & RichardB. Schlesinger. (1986) Changes in early alveolar particle clearance due to single and repeated nitrogen dioxide exposures in the rabbit. Journal of Toxicology and Environmental Health 19:2, pages 255-266.
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Richard F. Heller & Ronald E. Gordon. (1986) Chronic Effects of Nitrogen Dioxide on Cilia in Hamster Bronchioles. Experimental Lung Research 10:2, pages 137-152.
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D. M. Stavert, D. C. Archuleta, L. M. Holland & B. E. Lehnert. (1986) Nitrogen dioxide exposure and development of pulmonary emphysema. Journal of Toxicology and Environmental Health 17:2-3, pages 249-267.
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Katsumi Mochitate, Yuji Takahashi, Takumi Ohsumi & Takashi Miura. (1986) Activation and increment of alveolar macrophages induced by nitrogen dioxide. Journal of Toxicology and Environmental Health 17:2-3, pages 229-239.
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Katsumi Mochitate, Takashi Miura & Kentaro Kubota. (1985) An increase in the activities of glycolytic enzymes in rat lungs produced by nitrogen dioxide. Journal of Toxicology and Environmental Health 15:2, pages 323-331.
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PaulE. Morrow. (1984) Toxicological data on NO : An overview. Journal of Toxicology and Environmental Health 13:2-3, pages 205-227.
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Saburo Sone, LindaM. Brennan & DonaldA. Creasia. (1983) In vivo and in vitro no2 exposures enhance phagocytic and tumoricidal activities of rat alveolar macrophages. Journal of Toxicology and Environmental Health 11:1, pages 151-163.
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G. M. Rand, P. O. Nees, C. J. Calo, G. C. Clarke & N. A. Edmondson. (1982) The Clara cell: An electron microscopy examination of the terminal bronchioles of rats and monkeys following inhalation of hexachlorocyclopentadiene. Journal of Toxicology and Environmental Health 10:1, pages 59-72.
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Charles A. Tyson, Kenneth D. Lunan & Robert J. Stephens. (1982) Age-Related Differences in GSH-Shuttle Enzymes in NO2 – or O3 –Exposed Rat Lungs. Archives of Environmental Health: An International Journal 37:3, pages 167-176.
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DonaldA. Creasia. (1981) Pathogenesis of nitrogen dioxide‐induced respiratory lesions in reference to respiratory clearance of inhaled participates. Journal of Toxicology and Environmental Health 8:5-6, pages 857-871.
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JeanJ. Ospital, AllanD. Hacker & MohammadG. Mustafa. (1981) Biochemical changes in rat lungs after exposure to nitrogen dioxide. Journal of Toxicology and Environmental Health 8:1-2, pages 47-58.
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SUZANNE CHANEY, WENDY BLOMQUIST, PAULETTE DeWlTT & KEITH MULLER. (1981) Biochemical Changes in Humans Upon Exposure to Nitrogen Dioxide While at Rest. Archives of Environmental Health: An International Journal 36:2, pages 53-58.
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Carl Hugod. (1979) Ultrastructural Changes of the Rabbit Lung after a 5 ppm Nitric Oxide Exposure. Archives of Environmental Health: An International Journal 34:1, pages 12-17.
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D. A. Creasia. (1978) Stimulation of DNA synthesis in lungs of hamsters tolerant to nitrogen dioxide. Journal of Toxicology and Environmental Health 4:5-6, pages 755-762.
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Donald Rynbrandt & Jerome Kleinerman. (1977) Nitrogen Dioxide and Pulmonary-Proteolytic Enzymes. Archives of Environmental Health: An International Journal 32:4, pages 165-172.
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D. A. Creasia, P. Nettesheim & J. C. S. Kim. (1977) Stimulation of DNA synthesis in the lungs of hamsters exposed intermittently to nitrogen dioxide. Journal of Toxicology and Environmental Health 2:5, pages 1173-1181.
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Hanspeter Witschi, Michel G. C○té & Carroll E. Cross. (1977) Primary Pulmonary Responses to Toxic Agents. CRC Critical Reviews in Toxicology 5:1, pages 23-66.
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Robert A. Shakman. (1974) Nutritional Influences on the Toxicity of Environmental Pollutants. Archives of Environmental Health: An International Journal 28:2, pages 105-113.
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Maurice Stupfel, Monique Magnier, Françoise Romary, Marie-Hélène Tran & Jean-Paul Moutet. (1973) Lifelong Exposure of SPF Rats to Automotive Exhaust Gas. Archives of Environmental Health: An International Journal 26:5, pages 264-269.
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Gustave Freeman, Robert J. Stephens, David L. Coffin & Jerry P. Stara. (1973) Changes in Dogs’ Lungs After Long-Term Exposure to Ozone. Archives of Environmental Health: An International Journal 26:4, pages 209-216.
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Elliot Goldstein, M. Carroll Eagle, Paul D. Hoeprich, Paul Nettesheim & Anna S. Hammons. (1973) Effect of Nitrogen Dioxide on Pulmonary Bacterial Defense Mechanisms. Archives of Environmental Health: An International Journal 26:4, pages 202-204.
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