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Original Articles

Pulmonary Lesions Induced by Long-Term Exposure to Ozone

II. Ultrastructure Observations of Proliferative and Regressive Lesions

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Pages 282-289 | Received 02 Oct 1973, Accepted 03 Jul 1974, Published online: 29 Apr 2013

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Fred H. Royce & Charles G. Plopper. (1997) Effect of Chronic Daily Ozone Exposure on Clara Cell Secretory Protein mRNA Expression in the Adult Rat Lung. Experimental Lung Research 23:1, pages 51-64.
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Richard B. Schlesinger, John E. Gorczynski, Joanne Dennison, Larry Richards, Patrick L. Kinney & Maarten C. Bosland. (1992) Long-Term Intermittent Exposure to Sulfuric Acid Aerosol, Ozone, and Their Combination: Alterations in Tracheobronchial Mucociliary Clearance and Epithelial Secretory Cells. Experimental Lung Research 18:4, pages 505-534.
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JudithT. Zelikoff, Guat‐Lian Kraemer, Marie Claire Vogel & RichardB. Schlesinger. (1991) Immunomodulating effects of ozone on macrophage functions important for tumor surveillance and host defense. Journal of Toxicology and Environmental Health 34:4, pages 449-467.
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Hanspeter Witschi. (1991) Effects of Oxygen and Ozone on Mouse Lung Tumorigenesis. Experimental Lung Research 17:2, pages 473-483.
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ElaineS. Wright, DavidM. White, AlexandraN. Brady, LindaC. Li, JamesB. D'Arcy & KathleenL. Smiler. (1987) DNA synthesis in pulmonary alveolar macrophages and type II cells: Effects of ozone exposure and treatment with α‐difluoromethylornithine. Journal of Toxicology and Environmental Health 21:1-2, pages 15-26.
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L. E. Fujinaka, D. M. Hyde, C. G. Plopper, W. S. Tyler, D. L. Dungworth & L. O. Lollini. (1985) Respiratory Bronchiolitis Following Long-Term Ozone Exposure in Bonnet Monkeys: A Morphometric Study. Experimental Lung Research 8:2-3, pages 167-190.
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G. M. Rand, P. O. Nees, C. J. Calo, G. C. Clarke & N. A. Edmondson. (1982) The Clara cell: An electron microscopy examination of the terminal bronchioles of rats and monkeys following inhalation of hexachlorocyclopentadiene. Journal of Toxicology and Environmental Health 10:1, pages 59-72.
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John W. Osebold, Sally L. Owens, Yuan Chung Zee, William M. Dotson & David D. LaBarre. (1979) Immunological Alterations in the Lungs of Mice following Ozone Exposure: Changes in Immunoglobulin Levels and Antibody-Containing Cells. Archives of Environmental Health: An International Journal 34:4, pages 258-265.
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Congmeng Lyu, Shannon L Capps, Amir Hakami, Shunliu Zhao, Jaroslav Resler, Gregory R Carmichael, Adrian Sandu, Armistead G Russell, Tianfeng Chai & Daven K Henze. (2019) Elucidating emissions control strategies for ozone to protect human health and public welfare within the continental United States. Environmental Research Letters 14:12, pages 124093.
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. (2006) References. Clinical & Experimental Allergy 25:s3, pages 63-72.
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Roger McClellan & Rogene HendersonDonald Dungworth, Fletcher Hahn & Kristen Nikula. 1995. Concepts In Inhalation Toxicology. Concepts In Inhalation Toxicology 535 578 .
C.G. PLOPPER. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 1 24 .
Hanspeter Witschi, Dennis W. Wilson & Charles G. Plopper. (1993) Modulation of N-nitrosodiethylamine-induced hamster lung tumors by ozone. Toxicology 77:1-2, pages 193-202.
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Kenzo Hiroshima, Toshihiko Kohno, Hidemi Ohwada & Yutaka Hayashi. (1989) Morphological study of the effects of ozone on rat lung. Experimental and Molecular Pathology 50:2, pages 270-280.
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D.M. Hyde, C.G. Plopper, J.R. Harkema, J.A.St. George, W.S. Tyler & D.L. Dungworth. 1989. 523 532 .
Hanspeter Witschi. (1988) Ozone, nitrogen dioxide and lung cancer: A review of some recent issues and problems. Toxicology 48:1, pages 1-20.
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Kenzo Hiroshima, Toshihiko Kohno, Hidemi Owada & Yutaka Hayashi. (1987) A morphological study of the effects of ozone on rat lung. Experimental and Molecular Pathology 47:3, pages 327-345.
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P. G. Forkert & K. M. Troughton. (2005) Airway injury by trichloroethylene: A scanning electron microscopic study. The Journal of Pathology 152:2, pages 119-125.
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Johnny L. Carson, Albert M. Collier, Nancy G. Henshaw, Craig A. Smith & Shih-chin Hu. (1985) Response of human ciliated respiratory epithelium to brief in vivo ozone exposure: An ultrastructural study. Environmental Research 37:1, pages 212-227.
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R.S. Pemsingh, O.S. Atwal & R.B. MacPherson. (1985) Atypical cilia in ciliated cysts of the parathyroid glands of dogs exposed to ozone. Experimental pathology 28:2, pages 105-110.
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Jennifer M. Sturgess. 1985. Toxicology of Inhaled Materials. Toxicology of Inhaled Materials 319 367 .
Dennis W. Wilson, Charles G. Plopper & Dallas M. Hyde. (2005) The tracheobronchial epithelium of the bonnet monkey ( Macaca radiata ): A quantitative ultrastructural study . American Journal of Anatomy 171:1, pages 25-40.
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Norma Fakjian & Alan R. Buckpitt. (1984) Metabolism of bromobenzene to glutathione adducts in lung slices from mice treated with pneumotoxicants. Biochemical Pharmacology 33:9, pages 1479-1486.
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E. Yokoyama, I. Ichikawa, Z. Nambu, K. Kawai & Y. Kyono. (1984) Respiratory effects of intermittent exposure to ozone of rats. Environmental Research 33:2, pages 271-283.
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G. Lungarella, L. Fonzi & G. Ermini. (1983) Abnormalities of bronchial cilia in patients with chronic bronchitis. Lung 161:1, pages 147-156.
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Michael D. Rowe, Kenneth M. Novak & Paul D. Moskowitz. (1983) Health effects of oxidants. Environment International 9:6, pages 515-528.
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Susan G. Shami, Lawrence A. Thibodeau, Ann R. Kennedy & John B. Little. (1982) Recovery from ozone-induced injury in the lungs of the Syrian golden hamster. Experimental and Molecular Pathology 36:1, pages 57-71.
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N.G. Carmichael, C. Winder, S.H. Borges, B.L. Backhouse & P.D. Lewis. (1982) The health implications of water treatment with ozone. Life Sciences 30:2, pages 117-129.
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Helge Dalen. (1981) An ultrastructural study of primary cilia, abnormal cilia and ciliary knobs from the ciliated cells of the guinea-pig trachea. Cell and Tissue Research 220:4, pages 685-697.
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P.F. Moore & L.W. Schwartz. (1981) Morphological effects of prolonged exposure to ozone and sulfuric acid aerosol on the rat lung. Experimental and Molecular Pathology 35:1, pages 108-123.
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Ann R. Kennedy, Robert B. McGandy & John B. Little. (1977) Histochemical, light and electron microscopic study of polonium-210 induced peripheral tumors in hamster lungs: Evidence implicating the Clara cell as the cell of origin. European Journal of Cancer (1965) 13:11, pages 1325-1340.
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Carroll E. Cross, Anthony J. De Lucia, A.Krishna Reddy, M.Zamirul Hussain, Ching-Kuang Chow & Mohammad G. Mustafa. (1976) Ozone interactions with lung tissue. The American Journal of Medicine 60:7, pages 929-935.
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Michael J. Evans, Lincoln V. Johnson, Robert J. Stephens & Gustave Freeman. (1976) Cell renewal in the lungs of rats exposed to low levels of ozone. Experimental and Molecular Pathology 24:1, pages 70-83.
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