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Original Articles

Efficacy of Volatile Organic Compounds in Evoking Nasal Pungency and Odor

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Pages 309-314 | Received 31 Aug 1992, Accepted 11 Jan 1993, Published online: 03 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Richard L. Doty, J. Enrique Cometto-Muñiz, Alfredo A. Jalowayski, Pamela Dalton, Martin Kendal-Reed & Michael Hodgson. (2004) Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans. Critical Reviews in Toxicology 34:2, pages 85-142.
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Gerhard Andreas Wiesmüller, Christoph van Thriel, Achim Steup, Claus Bachert, Meinolf Blaszkewicz, Klaus Golka, Ernst Kiesswetter & Andreas Seeber. (2002) Nasal Function in Self-Reported Chemically Intolerant Individuals. Archives of Environmental Health: An International Journal 57:3, pages 247-254.
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J.H.E. Arts, J. Mojet, L.J. van Gemert, H.H. Emmen, J.H.C.M. Lammers, J. Marquart, R.A. Woutersen & V.J. Feron. (2002) An Analysis of Human Response to the Irritancy of Acetone Vapors. Critical Reviews in Toxicology 32:1, pages 43-66.
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V. J. Feron, J. H. E. Arts, C. F. Kuper, P. J. Slootweg & R. A. Woutersen. (2001) Health Risks Associated with Inhaled Nasal Toxicants. Critical Reviews in Toxicology 31:3, pages 313-347.
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Anne Korpi, Jukka-Pekka Kasanen, Yves Alarie, Veli-Matti Kosma & Anna-Liisa Pasanen. (1999) Sensory Irritating Potency of Some Microbial Volatile Organic Compounds (MVOCs) and a Mixture of Five MVOCs. Archives of Environmental Health: An International Journal 54:5, pages 347-352.
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RosalindC. Anderson & JuliusH. Anderson. (1998) Acute Toxic Effects of Fragrance Products. Archives of Environmental Health: An International Journal 53:2, pages 138-146.
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RosalindC. Anderson & JuliusH. Anderson. (1997) Toxic Effects of Air Freshener Emissions. Archives of Environmental Health: An International Journal 52:6, pages 433-441.
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CharlesJ. Wysocki, Pamela Dalton, MichaelJ. Brody & HenryJ. Lawley. (1997) Acetone Odor and Irritation Thresholds Obtained From Acetone-Exposed Factory Workers and From Control (Occupationally Unexposed) Subjects. American Industrial Hygiene Association Journal 58:10, pages 704-712.
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Articles from other publishers (52)

Michael G. Tyshenko, Calvin Willhite, Len Levy, Michelle Deveau, Melvin E. Andersen, Nataliya Karyakina, Andrew Maier, Franco Momoli, Tara S. Barton‐Maclaren & Daniel Krewski. 2003. Patty's Toxicology. Patty's Toxicology 1 42 .
John L. O'Donoghue. 2003. Patty's Toxicology. Patty's Toxicology 1 56 .
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Katarzyna Pielech-Przybylska, Maria Balcerek, Maciej Klebeko, Urszula Dziekońska-Kubczak & Mariusz Hebdzyński. (2022) Ethanolic Fermentation of Rye Mashes: Factors Influencing the Formation of Aldehydes and Process Efficiency. Biomolecules 12:8, pages 1085.
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I. Arias-Pérez, M.P. Sáenz-Navajas, A. de-la-Fuente-Blanco, V. Ferreira & A. Escudero. (2021) Insights on the role of acetaldehyde and other aldehydes in the odour and tactile nasal perception of red wine. Food Chemistry 361, pages 130081.
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A. V. Bobrov, M. V. Kishalova, A. A. Ksenofontov, S. D. Usoltsev & Yu. S. Marfin. (2021) Bodipy Based Fluorescent Materials in Cellulose Matrices: Synthesis, Spectral Properties and Vapochromic Fluorescent Recognition of Alcohols and Acetone. Journal of Fluorescence 31:6, pages 1627-1635.
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Alemayehu Worku, Tamás Tóth, Szilvia Orosz, Hedvig Fébel, László Kacsala, Balázs Húth, Richárd Hoffmann, Haruna Gado Yakubu, George Bazar & Róbert Tóthi. (2021) Aroma Profile, Microbial and Chemical Quality of Ensiled Green Forages Mixtures of Winter Cereals and Italian Ryegrass. Agriculture 11:6, pages 512.
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M. WACKERMANNOVÁ, L. PINC & L. JEBAVÝ. (2016) Olfactory Sensitivity in Mammalian Species. Physiological Research, pages 369-390.
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J. Enrique Cometto-Muñiz & Michael H. Abraham. (2016) Dose–Response Functions for the Olfactory, Nasal Trigeminal, and Ocular Trigeminal Detectability of Airborne Chemicals by Humans. Chemical Senses 41:1, pages 3-14.
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Michael H. Abraham, Joelle M.R. Gola & J. Enrique Cometto-Muñiz. (2016) An assessment of air quality reflecting the chemosensory irritation impact of mixtures of volatile organic compounds. Environment International 86, pages 84-91.
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Hessamedin Alimohammadi & Wayne L. Silver. (2015) Nasal Chemesthesis: Similarities Between Humans and Rats Observed in In Vivo Experiments. Chemosensory Perception 8:2, pages 85-95.
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J. Enrique Cometto‐Muñiz & Christopher Simons. 2015. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation 1089 1112 .
Mónica Bueno, M. Mar Campo, Juan Cacho, Vicente Ferreira & Ana Escudero. (2014) A model explaining and predicting lamb flavour from the aroma-active chemical compounds released upon grilling light lamb loins. Meat Science 98:4, pages 622-628.
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M. Alessandrini, A. Micarelli, E. Bruno, F. Ottaviani, M. Conetta, A. Cormano & G. Genovesi. (2013) Intranasal Administration of Hyaluronan as a Further Resource in Olfactory Performance in Multiple Chemical Sensitivity Syndrome. International Journal of Immunopathology and Pharmacology 26:4, pages 1019-1025.
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John L. O'Donoghue. 2003. Patty's Toxicology. Patty's Toxicology 753 806 .
M. H. Abraham, R. Sanchez-Moreno, J. E. Cometto-Muniz & W. S. Cain. (2011) An Algorithm for 353 Odor Detection Thresholds in Humans. Chemical Senses 37:3, pages 207-218.
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Stefan Kleinbeck, Michael Schäper, Stephanie A. Juran, Ernst Kiesswetter, Meinolf Blaszkewicz, Klaus Golka, Anna Zimmermann, Thomas Brüning & Christoph Van Thriel. (2011) Odor Thresholds and Breathing Changes of Human Volunteers as Consequences of Sulphur Dioxide Exposure Considering Individual Factors. Safety and Health at Work 2:4, pages 355-364.
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J. Enrique Cometto-Muñiz & Michael H. Abraham. (2010) Odor Detection by Humans of Lineal Aliphatic Aldehydes and Helional as Gauged by Dose–Response Functions. Chemical Senses 35:4, pages 289-299.
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Håkon L. Leira, Frode Fonnum & Tore Syversen. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
J. Enrique Cometto-Muñiz & Michael H. Abraham. (2009) Olfactory psychometric functions for homologous 2-ketones. Behavioural Brain Research 201:1, pages 207-215.
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J. Enrique Cometto-Muñiz, William S. Cain, Michael H. Abraham & Javier Gil-Lostes. (2008) Concentration-detection functions for the odor of homologous n-acetate esters. Physiology & Behavior 95:5, pages 658-667.
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J. Enrique Cometto-Muñiz & Michael H. Abraham. (2008) Human olfactory detection of homologous n-alcohols measured via concentration–response functions. Pharmacology Biochemistry and Behavior 89:3, pages 279-291.
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Josje H.E. Arts, Cees de Heer & Ruud A. Woutersen. (2005) Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits. International Archives of Occupational and Environmental Health 79:4, pages 283-298.
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Matthias Laska, Rosa Mariela Rivas Bautista & Laura Teresa Hernandez Salazar. (2006) Olfactory sensitivity for aliphatic alcohols and aldehydes in spider monkeys (Ateles geoffroyi). American Journal of Physical Anthropology 129:1, pages 112-120.
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Brett A. Johnson, Haleh Farahbod, Zhe Xu, Sepideh Saber & Michael Leon. (2004) Local and global chemotopic organization: General features of the glomerular representations of aliphatic odorants differing in carbon number. Journal of Comparative Neurology 480:2, pages 234-249.
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Christoph van Thriel, Gerhard A. Wiesmüller, Meinolf Blaszkewicz, Klaus Golka, Ernst Kiesswetter, Andreas Seeber & Claus Bachert. (2003) Intranasal effects in chemically sensitive volunteers: an experimental exposure study. Environmental Toxicology and Pharmacology 14:3, pages 129-137.
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Brent T Burton. (2003) Toxicologic considerations in workplace exposures. Immunology and Allergy Clinics of North America 23:2, pages 177-191.
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Robert Jennings Heinsohn & John Cimbala. 2003. Indoor Air Quality Engineering. Indoor Air Quality Engineering 819 846 .
J. Enrique Cometto‐Muñiz, William S. Cain, Michael H. Abraham & Joelle M. R. Gola. (2002) Psychometric functions for the olfactory and trigeminal detectability of butyl acetate and toluene. Journal of Applied Toxicology 22:1, pages 25-30.
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A. A. Jalowayski, B. N. Johnson, P. M. Wise, G. W. Schmid-Schonbein & W. S. Cain. (2001) Orbital Response Indicates Nasal Pungency: Analysis of Biomechanical Strain on the Skin. Chemical Senses 26:8, pages 1005-1013.
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Michael H. Abraham, Joëlle M.R. Gola, J. Enrique Cometto-Muñiz & William S. Cain. (2016) The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans. Indoor and Built Environment 10:3-4, pages 252-257.
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David A. Morgott, Douglas C. Topping & John L. O'Donoghue. 2003. Patty's Toxicology. Patty's Toxicology.
David A. Morgott. 2003. Patty's Toxicology. Patty's Toxicology.
J. E. Cometto-Muniz, W. S. Cain, T. Hiraishi, M. H. Abraham & J. M.R. Gola. (2000) Comparison of Two Stimulus-delivery Systems for Measurement of Nasal Pungency Thresholds. Chemical Senses 25:3, pages 285-291.
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K.M. Hau, D.W. Connell & B.J. Richardson. (2000) Use of Partition Models in Setting Health Guidelines for Volatile Organic Compounds. Regulatory Toxicology and Pharmacology 31:1, pages 22-29.
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Dennis Shusterman. (2001) The health significance of environmental odour pollution: revisited. Journal of Environmental Medicine 1:4, pages 249-258.
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P.M Ross, J Whysner, V.T Covello, M Kuschner, A.B Rifkind, M.J Sedler, D Trichopoulos & G.M Williams. (1999) Olfaction and Symptoms in the Multiple Chemical Sensitivities Syndrome. Preventive Medicine 28:5, pages 467-480.
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Yves Alarie, Gunnar Damgård Nielsen & Michael H. Abraham. (2009) A Theoretical Approach to the Ferguson Principle and its Use with Non‐Reactive and Reactive Airborne Chemicals. Pharmacology & Toxicology 83:6, pages 270-279.
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Gunnar Damgård Nielsen, Lea Frimann Hansen, Bjørn Andersen Nexø & Otto Melchior Poulsen. (1998) Indoor Air Guideline Levels for Phenol and Butylated Hydroxytoluene (BHT). Indoor Air 8:S5, pages 25-36.
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P. J. D. DAWES. (1998) Clinical tests of olfaction. Clinical Otolaryngology and Allied Sciences 23:6, pages 484-490.
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M. H. Abraham, R. Kumarsingh, J.E. Cometto-Muniz & W.S. Cain. (1998) Draize Eye Scores and Eye Irritation Thresholds in Man Combined into one Quantitative Structure–Activity Relationship. Toxicology in Vitro 12:4, pages 403-408.
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K. M. Hau & D. W. Connell. (1998) Quantitative Structure-Activity Relationships (QSARs) for Odor Thresholds of Volatile Organic Compounds (VOCs). Indoor Air 8:1, pages 23-33.
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Bruce H. Ackerman & Nishaminy Kasbekar. (2012) Disturbances of Taste and Smell Induced by Drugs. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17:3, pages 482-496.
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Gunnar Damgard Njelsen, Lea Frimann Hansen & Peder Wolkoff. (1997) Chemical and Biological Evaluation of Building Material Emissions. II. Approaches for Setting Indoor Air Standards or Guidelines for Chemicals. Indoor Air 7:1, pages 17-32.
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Gunnar Damgard Nielsen, Lea Frimann Hansen, Maria Hammer, Karl Ventzel Vejrup & Peder Wolkoff. (1997) Chemical and Biological Evaluation of Building Material Emissions. I. A Screening Procedure based on a Closed Emission System*. Indoor Air 7:1, pages 8-16.
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J. Enrique Cometto-Muñiz, William S. Cain & H. Kenneth Hudnell. (1997) Agonistic sensory effects of airborne chemicals in mixtures: Odor, nasal pungency, and eye irritation. Perception & Psychophysics 59:5, pages 665-674.
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Peder Wolkoff & Peter A. Nielsen. (1996) A new approach for indoor climate labeling of building materials—emission testing, modeling, and comfort evaluation. Atmospheric Environment 30:15, pages 2679-2689.
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Peder Wolkoff. (1995) Volatile Organic Compounds Sources, Measurements, Emissions, and the Impact on Indoor Air Quality. Indoor Air 5:S3, pages 5-73.
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R. D. BUTCHER, W. MACFARLANE‐SMITH, G. W. ROBERTSON & D. W. GRIFFITHS. (2013) The identification of potential aeroallergen/irritant(s) from oilseed rape ( Brassica napus spp. oleifera ): volatile organic compounds emitted during flowering progression . Clinical & Experimental Allergy 24:12, pages 1105-1114.
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J. Enrique Cometto-Muniz & William S. Cain. (1994) Perception of Odor and Nasal Pungency from Homologous Series of Volatile Organic Compounds. Indoor Air 4:3, pages 140-145.
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