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Original Articles

Neurobehavioral Impairment and Seizures from Formaldehyde

Pages 37-44 | Accepted 20 Jul 1993, Published online: 03 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Didem Dönmez Aydin, Oğuz Taşkınalp, Enis Uluçam, Hakan Karadağ, Gülnur Kızılay Özfidan, Ruhan Topuz & Onur Ersoy. (2023) The effect of acute and chronic formaldehyde exposure on learning and memory in male and female rats. International Journal of Neuroscience 0:0, pages 1-9.
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Jiaying Cheng, Long Zhang, Yufu Tang & Zhenhai Li. (2016) The toxicity of continuous long-term low-dose formaldehyde inhalation in mice. Immunopharmacology and Immunotoxicology 38:6, pages 495-501.
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Ren-Xiu Bian, Jae-Young Han, Jung-Kook Kim, In-Sung Choi, Sam-Gyu Lee, Jong-Seong Park & Young-Do Jung. (2012) The effect of chronic formaldehyde exposure on the hippocampus in chronic cerebral hypoperfusion rat model. Toxicological & Environmental Chemistry 94:6, pages 1211-1224.
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Rui Zhang, In Kyung Lee, Kyoung Ah Kang, Mei Jing Piao, Ki Cheon Kim, Bum Joon Kim, Nam Ho Lee, Jeong-Yun Choi, Jinhee Choi & Jin Won Hyun. (2010) Cytoprotective Effects of Triphlorethol-A Against Formaldehyde-Induced Oxidative Damage and Apoptosis: Role of Mitochondria-Mediated Caspase-Dependent Pathway. Journal of Toxicology and Environmental Health, Part A 73:21-22, pages 1477-1489.
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Ahmet Songur, Mustafa Sarsilmaz, Oguz Ozen, Semsettin Sahin, Resit Koken, Ismail Zararsiz & Necip Ilhan. (2008) The Effects of Inhaled Formaldehyde on Oxidant and Antioxidant Systems of Rat Cerebellum During the Postnatal Development Process. Toxicology Mechanisms and Methods 18:7, pages 569-574.
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GregA. Wooster, CasandraM. Martinez, PaulR. Bowser & DustinS. O'Hara. (2005) Human Health Risks Associated with Formalin Treatments Used in Aquaculture: Initial Study. North American Journal of Aquaculture 67:2, pages 111-113.
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Kaye H. Kilburn. (2003) Indoor Mold Exposure Associated with Neurobehavioral and Pulmonary Impairment: A Preliminary Report. Archives of Environmental Health: An International Journal 58:7, pages 390-398.
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Lennart Friis, Dan Norbäck & Christer Edling. (1997) Occurrence of Neuropsychiatric Symptoms at Low Levels of Occupational Exposure to Organic Solvents and Relationships to Health, Lifestyle, and Stress. International Journal of Occupational and Environmental Health 3:3, pages 184-189.
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Articles from other publishers (57)

Lin Wang, Yanyan Ma & Weiying Lin. (2024) Construction of a turn-on fluorescent probe for detecting formaldehyde in biological systems and real food samples. Food Chemistry 450, pages 139315.
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Danrui Zhao, Yiqing Wu, Hang Zhao, Fengji Zhang, Junting Wang, Yiying Liu, Jing Lin, Yirui Huang, Wenhao Pan, Jiahui Qi, Nan Chen, Xu Yang, Wen Xu, Zhiqian Tong & Jianhua Cheng. (2024) Midbrain FA initiates neuroinflammation and depression onset in both acute and chronic LPS-induced depressive model mice. Brain, Behavior, and Immunity 117, pages 356-375.
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Zukun Wang, Junjie Liu, Jiajing Wang, Dandan Guo, Jingjing Pei, Lei Zhao, Xin Zhang, Jie Liu, Yuying Li, Meili Deng, Mingrui Cui, Yuan Yang, Lulin Zhang, Xiao Qin, Changqing Zhan & Yijun Song. (2022) Effect of low concentrations of indoor toluene on cognitive performance: EEG-based evidence. Building and Environment 224, pages 109494.
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Pengsheng Wei, Xue Li, Shuai Wang, Yanxin Dong, Haoran Yin, Zikun Gu, Xiaoting Na, Xi Wei, Jiayu Yuan, Jiahui Cao, Haotian Gao, Yebo Su, Yong Xu Chen & Ge Jin. (2022) Silibinin Ameliorates Formaldehyde-Induced Cognitive Impairment by Inhibiting Oxidative Stress. Oxidative Medicine and Cellular Longevity 2022, pages 1-13.
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Rubayat Rezoana, Latifa Akter, Rafiqul Islam, Sonali Bhakta, Ummay Ayman, Mohammad Rabiul Karim & Ziaul Haque. (2022) The hazardous effects of formalin and alcoholic fixative in mice: A public health perspective study. Saudi Journal of Biological Sciences 29:5, pages 3366-3371.
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Xuechao Fei, Yun Zhang, Yufei Mei, Xiangpei Yue, Wenjing Jiang, Li Ai, Yan Yu, Hongjun Luo, Hui Li, Wenhong Luo, Xu Yang, Jihui Lyv, Rongqiao He, Weihong Song & Zhiqian Tong. (2020) Degradation of FA reduces Aβ neurotoxicity and Alzheimer-related phenotypes. Molecular Psychiatry 26:10, pages 5578-5591.
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Mohit Pant, Siddhartha Dan, Sujata Pant, Aditya Raj & Sushil Kumar Upadhyay. (2021) Progression in Alzheimer’s Disease Correlates With Epigenetics and Cerebral Formaldehyde: From Potential Hereditary Mechanism and Environmental Factors to Therapeutic Measures. Current Pharmacology Reports 7:5, pages 187-205.
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N S Yasa, L Anshory, S J. Purnomo & G M Samadan. (2020) Induction of Hsp60, Hsp70, and Hsp90 in formalin exposed white shrimp ( Litopenaeus vannamei ) stress test . IOP Conference Series: Earth and Environmental Science 584, pages 012054.
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Huatao Niu, Ran Xie, Lanjiang Li, Xiang Zhang, Xiaohan Wei, Jie Deng & Zhongming Li. (2020) WITHDRAWN: Resveratrol partially prevents learning and memory deficits in rats exposed to gaseous formaldehyde. Environmental Toxicology and Pharmacology.
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Nuriye Tuna Subasi. 2020. Biochemical Toxicology - Heavy Metals and Nanomaterials. Biochemical Toxicology - Heavy Metals and Nanomaterials.
Xiang Li, Yuan-Yuan Zhuang, Lei Wu, Ming Xie, Hong-Feng Gu, Bo Wang & Xiao-Qing Tang. (2020) Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor. Neuropsychobiology 79:2, pages 119-130.
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Joseph L. Dempsey, Mallory Little & Julia Yue Cui. (2019) Gut microbiome: An intermediary to neurotoxicity. NeuroToxicology 75, pages 41-69.
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Hyun-Jeong Eom, Yuedan Liu, Gyu-Suk Kwak, Muyoung Heo, Kyung Seuk Song, Yun Doo Chung, Tae-Soo Chon & Jinhee Choi. (2017) Inhalation toxicity of indoor air pollutants in Drosophila melanogaster using integrated transcriptomics and computational behavior analyses. Scientific Reports 7:1.
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Rongqiao HeJing Lu & Rongqiao He. 2017. Formaldehyde and Cognition. Formaldehyde and Cognition 167 189 .
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Jason S. Garcia & Raymond D. Harbison. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 445 490 .
Jia-Mei Jiang, Cheng-Fang Zhou, Sheng-Lan Gao, Ying Tian, Chun-Yan Wang, Li Wang, Hong-Feng Gu & Xiao-Qing Tang. (2015) BDNF-TrkB Pathway Mediates Neuroprotection of Hydrogen Sulfide against Formaldehyde-Induced Toxicity to PC12 Cells. PLOS ONE 10:3, pages e0119478.
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Ali Louei Monfared. (2012) Histomorphological and ultrastructural changes of the placenta in mice exposed to formaldehyde. Toxicology and Industrial Health 30:2, pages 174-181.
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Xiang Li, Kai-Yan Zhang, Ping Zhang, Li-Xun Chen, Li Wang, Ming Xie, Chun-Yan Wang & Xiao-Qing Tang. (2014) Hydrogen Sulfide Inhibits Formaldehyde-Induced Endoplasmic Reticulum Stress in PC12 Cells by Upregulation of SIRT-1. PLoS ONE 9:2, pages e89856.
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Zhiqian Tong, Chanshuai Han, Wenhong Luo, Xiaohui Wang, Hui Li, Hongjun Luo, Jiangning Zhou, Jinshun Qi & Rongqiao He. (2012) Accumulated hippocampal formaldehyde induces age-dependent memory decline. AGE 35:3, pages 583-596.
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Zhiqian Tong, Chanshuai Han, Wenhong Luo, Hui Li, Hongjun Luo, Min Qiang, Tao Su, Beibei Wu, Ying Liu, Xu Yang, You Wan, Dehua Cui & Rongqiao He. (2013) Aging-associated excess formaldehyde leads to spatial memory deficits. Scientific Reports 3:1.
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Xiao-Qing Tang, Heng-Rong Fang, Cheng-Fang Zhou, Yuan-Yuan Zhuang, Ping Zhang, Hong-Feng Gu & Bi Hu. (2013) A Novel Mechanism of Formaldehyde Neurotoxicity: Inhibition of Hydrogen Sulfide Generation by Promoting Overproduction of Nitric Oxide. PLoS ONE 8:1, pages e54829.
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Xiao-Qing Tang, Yuan-Yuan Zhuang, Ping Zhang, Heng-Rong Fang, Cheng-Fang Zhou, Hong-Feng Gu, Hui Zhang & Chun-Yan Wang. (2012) Formaldehyde Impairs Learning and Memory Involving the Disturbance of Hydrogen Sulfide Generation in the Hippocampus of Rats. Journal of Molecular Neuroscience 49:1, pages 140-149.
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Xiao-Qing Tang, Yan-Kai Ren, Cheng-Fang Zhou, Chun-Tao Yang, Hong-Feng Gu, Jian-Qin He, Rong-Qian Chen, Yuan-Yuan Zhuang, Heng-Rong Fang & Chun-Yan Wang. (2012) Hydrogen sulfide prevents formaldehyde-induced neurotoxicity to PC12 cells by attenuation of mitochondrial dysfunction and pro-apoptotic potential. Neurochemistry International 61:1, pages 16-24.
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Fu-Cheng Luo, Jia Zhou, Tao Lv, Lei Qi, Sheng-Dong Wang, Hajime Nakamura, Junji Yodoi & Jie Bai. (2012) Induction of endoplasmic reticulum stress and the modulation of thioredoxin-1 in formaldehyde-induced neurotoxicity. NeuroToxicology 33:3, pages 290-298.
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Ismail ZararsizSedat Meydan, Mustafa Sarsilmaz, Ahmet Songur, Oguz Aslan Ozen & Sadik Sogut. (2011) Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats. Toxicology and Industrial Health 27:6, pages 489-495.
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Xiao‐Qing Tang, Yan‐Kai Ren, Rong‐Qian Chen, Yuan‐Yuan Zhuang, Heng‐Rong Fang, Jin‐Hua Xu, Chun‐Yan Wang & Bi Hu. (2011) Formaldehyde induces neurotoxicity to PC12 cells involving inhibition of paraoxonase‐1 expression and activity. Clinical and Experimental Pharmacology and Physiology 38:4, pages 208-214.
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RongQiao He, Jing Lu & JunYe Miao. (2010) Formaldehyde stress. Science China Life Sciences 53:12, pages 1399-1404.
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Y. Liu, Z. Ye, H. Yang, L. Zhou, D. Fan, S. He & D. Chui. (2010) Disturbances of soluble N-ethylmaleimide-sensitive factor attachment proteins in hippocampal synaptosomes contribute to cognitive impairment after repetitive formaldehyde inhalation in male rats. Neuroscience 169:3, pages 1248-1254.
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Kyong Hoon Ahn, Seok Kyun Kim, Jung Min Lee, Hyung Jun Jeon, Dong Hoon Lee & Dae Kyong Kim. (2010) Proteomic Analysis of Bronchoalveolar Lavage Fluid Obtained from Rats Exposed to Formaldehyde. Journal of Health Science 56:3, pages 287-295.
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Ahmet Songur, Oguz Aslan Ozen & Mustafa Sarsilmaz. 2010. Reviews of Environmental Contamination and Toxicology Vol 203. Reviews of Environmental Contamination and Toxicology Vol 203 105 118 .
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Yi Liu, Zhanlei Ye, Hanzhi Luo, Miao Sun, Mi Li, Dongsheng Fan & Dehua Chui. (2009) Inhalative formaldehyde exposure enhances aggressive behavior and disturbs monoamines in frontal cortex synaptosome of male rats. Neuroscience Letters 464:2, pages 113-116.
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Z. Lu, C.M. Li, Y. Qiao, Y. Yan & X. Yang. (2008) Effect of inhaled formaldehyde on learning and memory of mice. Indoor Air 18:2, pages 77-83.
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Ismail Zararsiz, Ilter Kus, Murat Ogeturk, Nusret Akpolat, Evren Kose, Sedat Meydan & Mustafa Sarsilmaz. (2006) Melatonin prevents formaldehyde‐induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study. Cell Biochemistry and Function 25:4, pages 413-418.
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Mustafa Sarsilmaz, Suleyman Kaplan, Ahmet Songur, Serdar Colakoglu, Huseyin Aslan, Ayten Turkkani Tunc, Oguz Aslan Ozen, Mehmet Turgut & Orhan Baş. (2007) Effects of postnatal formaldehyde exposure on pyramidal cell number, volume of cell layer in hippocampus and hemisphere in the rat: A stereological study. Brain Research 1145, pages 157-167.
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Ismail Zararsiz, Ilter Kus, Nusret Akpolat, Ahmet Songur, Murat Ogeturk & Mustafa Sarsilmaz. (2006) Protective effects of ω-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats. Cell Biochemistry and Function 24:3, pages 237-244.
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